[논문]Predicting dementia from primary care records: A systematic review and meta-analysis

Ford, Elizabeth; Greenslade, Nicholas; Paudyal, Priya; Bremner, Stephen; Smith, Helen E.; Banerjee, Sube; Sadhwani, Shanu; Rooney, Philip; Oliver, Seb; Cassell, Jackie

doi:10.1371/journal.pone.0194735

Predicting dementia from primary care records: A systematic review and meta-analysis 원문보기

PloS one, v.13 no.3, 2018년, pp.e0194735 -

Ford, Elizabeth (Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, United Kingdom) , Greenslade, Nicholas (Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, United Kingdom) , Paudyal, Priya (Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, United Kingdom) , Bremner, Stephen (Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, United Kingdom) , Smith, Helen E. (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore) , Banerjee, Sube (Centre for Dementia Studies, Brighton and Sussex Medical School, Brighton, United Kingdom) , Sadhwani, Shanu (Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, United Kingdom) , Rooney, Philip (Department of Physics and Astronomy, University of Sussex, Brighton United Kingdom) , Oliver, Seb (Department of Physics and Astronomy, University of Sussex, Brighton United Kingdom) , Cassell, Jackie (Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, United Ki)

Abstract ▼ AI-Helper

IntroductionPossible dementia is usually identified in primary care by general practitioners (GPs) who refer to specialists for diagnosis. Only two-thirds of dementia cases are currently recorded in primary care, so increasing the proportion of cases diagnosed is a strategic priority for the UK and internationally. Variables in the primary care record may indicate risk of developing dementia, and could be combined in a predictive model to help find patients who are missing a diagnosis. We conducted a meta-analysis to identify clinical entities with potential for use in such a predictive model for dementia in primary care.Methods and findingsWe conducted a systematic search in PubMed, Web of Science and primary care database bibliographies. We included cohort or case-control studies which used routinely collected primary care data, to measure the association between any clinical entity and dementia. Meta-analyses were performed to pool odds ratios. A sensitivity analysis assessed the impact of non-independence of cases between studies.From a sift of 3836 papers, 20 studies, all European, were eligible for inclusion, comprising >1 million patients. 75 clinical entities were assessed as risk factors for all cause dementia, Alzheimer’s (AD) and Vascular dementia (VaD). Data included were unexpectedly heterogeneous, and assumptions were made about definitions of clinical entities and timing as these were not all well described. Meta-analysis showed that neuropsychiatric symptoms including depression, anxiety, and seizures, cognitive symptoms, and history of stroke, were positively associated with dementia. Cardiovascular risk factors such as hypertension, heart disease, dyslipidaemia and diabetes were positively associated with VaD and negatively with AD. Sensitivity analyses showed similar results.ConclusionsThese findings are of potential value in guiding feature selection for a risk prediction tool for dementia in primary care. Limitations include findings being UK-focussed. Further predictive entities ascertainable from primary care data, such as changes in consulting patterns, were absent from the literature and should also be explored in future studies.

참고문헌 (55)

1 Prince M , Wimo A , Guerchet M , Ali G , Wu Y , Prina M , et al World Alzheimer Report 2015: The Global Impact of Dementia . 2015 .
2 Banerjee S . The Macroeconomics of Dementia—Will the World Economy Get Alzheimer's Disease? Archives of Medical Research . 2012 ; 43 ( 8 ): 705 – 9 . doi: 10.1016/j.arcmed.2012.10.006 23085453

상세보기
3 Prince M , Bryce R , Ferr C . Alzheimer's Disease International World Alzheimer Report 2011: The benefits of early diagnosis and intervention . Institute of Psychiatry King's College London Alzheimer's Disease International 2011 .
4 Banerjee S , Wittenberg R . Clinical and cost effectiveness of services for early diagnosis and intervention in dementia . International journal of geriatric psychiatry . 2009 ; 24 ( 7 ): 748 – 54 . doi: 10.1002/gps.2191 19206079

상세보기
5 Iliffe S , Manthorpe J , Eden A . Sooner or later? Issues in the early diagnosis of dementia in general practice: a qualitative study . Family Practice . 2003 ; 20 ( 4 ): 376 – 81 . 12876106

상세보기
6 Department of Health. Living well with dementia: A National Dementia Strategy 2009. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/168220/dh_094051.pdf .
7 Department of Health. Prime Minister’s challenge on dementia: Delivering major improvements in dementia care and research by 2015 2012. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/215101/dh_133176.pdf .
8 NHS England. Enhanced Service Specification: Dementia Identification Scheme 2014. Available from: http://www.england.nhs.uk/wp-content/uploads/2014/10/dementia-ident-schm-fin.pdf .
9 Barrett E , Burns A . Dementia Revealed: What Primary Care Needs to Know : Hardwick CCG, NHS England, Department of Health, Royal College of General Practitioners ; 2014 Available from: http://www.england.nhs.uk/wp-content/uploads/2014/09/dementia-revealed-toolkit.pdf .
10 Pentzek M , Wollny A , Wiese B , Jessen F , Haller F , Maier W , et al Apart from nihilism and stigma: what influences general practitioners' accuracy in identifying incident dementia? The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry . 2009 ; 17 ( 11 ): 965 – 75 . Epub 2010/01/28. doi: 10.1097/JGP.0b013e3181b2075e . 20104054

상세보기
11 Connolly A , Gaehl E , Martin H , Morris J , Purandare N . Underdiagnosis of dementia in primary care: variations in the observed prevalence and comparisons to the expected prevalence . Aging & mental health . 2011 ; 15 ( 8 ): 978 – 84 . Epub 2011/07/23. doi: 10.1080/13607863.2011.596805 . 21777080

상세보기
12 Stephan BCM , Tang E , Muniz-Terrera G . Composite risk scores for predicting dementia . Curr Opin Psychiatr . 2016 ; 29 ( 2 ): 174 – 80 . doi: 10.1097/yco.0000000000000235 . WOS:000369605700012. 26779863
13 Stephan BC , Kurth T , Matthews FE , Brayne C , Dufouil C . Dementia risk prediction in the population: are screening models accurate? Nat Rev Neurol . 2010 ; 6 doi: 10.1038/nrneurol.2010.54 20498679

상세보기
14 Stephan BC , Brayne C . Risk factors and screening methods for detecting dementia: a narrative review . J Alzheimers Dis . 2014 ; 42 .
15 Booth N . What are the Read Codes? Health Libr Rev . 1994 ; 11 ( 3 ): 177 – 82 . doi: 10.1046/j.1365-2532.1994.1130177.x 10139676

상세보기
16 CPRD. https://www.cprd.com/ [Accessed 6th June 2016].
17 THIN. The Health Improvement Network https://www.ucl.ac.uk/pcph/research-groups-themes/thin-pub/publications [Accessed 6th June 2016].
18 Ramakers IH , Visser PJ , Aalten P , Boesten JH , Metsemakers JF , Jolles J , et al Symptoms of preclinical dementia in general practice up to five years before dementia diagnosis . Dement Geriatr Cogn Disord . 2007 ; 24 ( 4 ): 300 – 6 . Epub 2007/08/25. doi: 10.1159/000107594 . 17717417

상세보기
19 Jammeh E , Carroll C , Pearson S , Escudero J , Anastasiou A , Zajicek J , et al Using primary care data to identify undiagnosed dementia . J Neurol Neurosurg Psychiatry . 2015 ; 86 ( 11 ): e4 -e. doi: 10.1136/jnnp-2015-312379.44
20 Walters K , Hardoon S , Petersen I , Iliffe S , Omar RZ , Nazareth I , et al Predicting dementia risk in primary care: development and validation of the Dementia Risk Score using routinely collected data . BMC Medicine . 2016 ; 14 ( 1 ): 1 – 12 . doi: 10.1186/s12916-016-0549-y 26728489
21 Moher D , Liberati A , Tetzlaff J , Altman DG . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement . Ann Int Med . 2009 ; 151 ( 4 ): 264 – 9 . 19622511
22 Park J, Lee Y, Seo H, Jang B, Son H, Kim S, et al., editors. Risk of bias assessment tool for non-randomized studies (RoBANS): development and validation of a new instrument. 19th Cochrane Colloquium; 2011.
23 Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses . Eur J Epidemiol . 2010 ; 25 ( 9 ): 603 – 5 . doi: 10.1007/s10654-010-9491-z 20652370

상세보기
24 Deeks J, Higgins J, Altman D, Green S. Cochrane handbook for systematic reviews of interventions version 5.1. 0 (updated March 2011). The Cochrane Collaboration. 2011.
25 Burton C , Campbell P , Jordan K , Strauss V , Mallen C . The association of anxiety and depression with future dementia diagnosis: a case-control study in primary care . Family Practice . 2012 ; 30 ( 1 ): 25 – 30 . doi: 10.1093/fampra/cms044 22915794
26 Davies NM , Kehoe PG , Ben-Shlomo Y , Martin RM . Associations of Anti-Hypertensive Treatments with Alzheimer's Disease, Vascular Dementia and Other Dementias . J Alz Dis . 2011 ; 26 : 699 – 708 .
27 Dunn N , Mullee M , Perry V , Holmes C . Association between dementia and infectious disease: evidence from a case-control study . Alzheimer Dis Assoc Disord . 2005 ; 19 ( 2 ): 91 – 4 . 15942327

상세보기
28 Imfeld P , Bodmer M , Jick SS , Meier CR . Benzodiazepine Use and Risk of Developing Alzheimer's Disease or Vascular Dementia: A Case-Control Analysis . Drug safety . 2015 Epub 2015/07/01. doi: 10.1007/s40264-015-0319-3 . 26123874
29 Imfeld P , Bodmer M , Jick SS , Meier CR . Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population‐Based Case–Control Study . J Am Geriatr Soc . 2012 ; 60 ( 5 ): 916 – 21 . doi: 10.1111/j.1532-5415.2012.03916.x 22458300

상세보기
30 Imfeld P , Toovey S , Jick SS , Meier CR . Influenza infections and risk of Alzheimer's disease . Brain, behavior, and immunity . 2016 ; 57 : 187 – 92 . Epub 2016/03/24. doi: 10.1016/j.bbi.2016.03.014 . 27006278

상세보기
31 Seshadri S , Zornberg GL , Derby LE , Myers MW , Jick H , Drachman DA . Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease . Arch Neurol . 2001 ; 58 ( 3 ): 435 – 40 . 11255447

상세보기
32 Jick H , Zornberg GL , Jick SS , Seshadri S , Drachman DA . Statins and the risk of dementia . Lancet . 2000 ; 356 : 1627 – 31 . 11089820
33 Dunn N , Holmes C , Mullee M . Does lithium therapy protect against the onset of dementia? Alzheimer Dis Assoc Disord . 2005 ; 19 ( 1 ): 20 – 2 . 15764867

상세보기
34 Imfeld P , Bodmer M , Schuerch M , Jick SS , Meier CR . Seizures in patients with Alzheimer's disease or vascular dementia: A population-based nested case-control analysis . Epilepsia . 2013 ; 54 ( 4 ): 700 – 7 . doi: 10.1111/epi.12045 23215680

상세보기
35 Imfeld P , Pernus YBB , Jick SS , Meier CR . Epidemiology, Co-Morbidities, and Medication Use of Patients with Alzheimer's Disease or Vascular Dementia in the UK . J Alzheimers Dis . 2013 ; 35 : 565 – 73 . doi: 10.3233/JAD-121819 23455986
36 Dregan A , Chowienczyk P , Armstrong D . Patterns of anti‐inflammatory drug use and risk of dementia: a matched case–control study . Eur J Neurol . 2015 ; 22 ( 11 ): 1421 – 8 . doi: 10.1111/ene.12774 26177125

상세보기
37 Dregan A , Chowienczyk P , Gulliford MC . Are inflammation and related therapy associated with all-cause dementia in a primary care population? J Alz Dis . 2015 ; 46 ( 4 ): 1039 – 47 .
38 Köhler S , Buntinx F , Palmer K , Akker M . Depression, vascular factors, and risk of dementia in primary care: a retrospective cohort study . J Am Geriatr Soc . 2015 ; 63 ( 4 ): 692 – 8 . doi: 10.1111/jgs.13357 25900484

상세보기
39 Buntinx F , Kester A , Bergers J , Knottnerus JA . Is depression in elderly people followed by dementia? A retrospective cohort study based in general practice . Age and ageing . 1996 ; 25 ( 3 ): 231 – 3 . Epub 1996/05/01. . 8670559

상세보기
40 Booker A , Jacob LE , Rapp M , Bohlken J , Kostev K . Risk factors for dementia diagnosis in German primary care practices . Int Psychogeriatr . 2016 ; 28 ( 7 ): 1059 – 65 . Epub 2016/01/09. doi: 10.1017/S1041610215002082 . 26744954

상세보기
41 Wagner G , Icks A , Abholz HH , Schroder-Bernhardi D , Rathmann W , Kostev K . Antihypertensive treatment and risk of dementia: a retrospective database study . Int J Clin Pharmacol Ther . 2012 ; 50 ( 3 ): 195 – 201 . Epub 2012/03/01. . 22373832

상세보기
42 Kessing LV , Søndergård L , Forman JL , Andersen PK . Lithium treatment and risk of dementia . Archives of general psychiatry . 2008 ; 65 ( 11 ): 1331 – 5 . doi: 10.1001/archpsyc.65.11.1331 18981345

상세보기
43 Speck CE , Kukull WA , Brenner DE , Bowen JD , McCormick WC , Ten L , et al History of depression as a risk factor for Alzheimer's disease . Epidemiology . 1995 ; 6 ( 4 ): 366 – 9 . 7548342

상세보기
44 Ferretti L , McCurry SM , Logsdon R , Gibbons L , Teri L . Anxiety and Alzheimer's Disease . J Geriatr Psychiatry Neurol . 2001 ; 14 ( 1 ): 52 – 8 . doi: 10.1177/089198870101400111 11281317

상세보기
45 Sherzai D , Losey T , Vega S , Sherzai A . Seizures and dementia in the elderly: Nationwide Inpatient Sample 1999–2008 . Epilepsy Behav . 2014 ; 36 : 53 – 6 . doi: 10.1016/j.yebeh.2014.04.015 24857809

상세보기
46 Ballard C , Neill D , O’brien J , McKeith I , Ince P , Perry R . Anxiety, depression and psychosis in vascular dementia: prevalence and associations . Journal of affective disorders . 2000 ; 59 ( 2 ): 97 – 106 . 10837878

상세보기
47 Seignourel PJ , Kunik ME , Snow L , Wilson N , Stanley M . Anxiety in dementia: a critical review . Clin Psychol Rev . 2008 ; 28 ( 7 ): 1071 – 82 . doi: 10.1016/j.cpr.2008.02.008 18555569

상세보기
48 Cui X , Lyness JM , Tu X , King DA , Caine ED . Does depression precede or follow executive dysfunction? Outcomes in older primary care patients . The American journal of psychiatry . 2007 ; 164 ( 8 ): 1221 – 8 . Epub 2007/08/03. doi: 10.1176/appi.ajp.2007.06040690 . 17671285

상세보기
49 Green RC , Cupples L , Kurz A , et al Depression as a risk factor for alzheimer disease: The mirage study . Arch Neurol . 2003 ; 60 ( 5 ): 753 – 9 . doi: 10.1001/archneur.60.5.753 12756140

상세보기
50 Romanelli MF , Morris JC , Ashkin K , Coben LA . Advanced Alzheimer’s disease is a risk factor for late-onset seizures . Arch Neurol . 1990 ; 47 ( 8 ): 847 – 50 . 2375689

상세보기
51 Rosendorff C , Beeri MS , Silverman JM . Cardiovascular Risk Factors for Alzheimer's Disease . Am J Geriatr Cardiol . 2007 ; 16 ( 3 ): 143 – 9 . doi: 10.1111/j.1076-7460.2007.06696.x 17483665

상세보기
52 Kivipelto M , Ngandu T , Laatikainen T , Winblad B , Soininen H , Tuomilehto J . Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study . Lancet Neurol . 2006 ; 5 doi: 10.1016/s1474-4422(06)70537-3

상세보기
53 Kivipelto M , Ngandu T , Fratiglioni L , et al Obesity and vascular risk factors at midlife and the risk of dementia and alzheimer disease . Arch Neurol . 2005 ; 62 ( 10 ): 1556 – 60 . doi: 10.1001/archneur.62.10.1556 16216938

상세보기
54 Driver JA , Beiser A , Au R , Kreger BE , Splansky GL , Kurth T , et al Inverse association between cancer and Alzheimer’s disease: results from the Framingham Heart Study . Brit Med J . 2012 ; 344 doi: 10.1136/bmj.e1442 22411920
55 Beeri MS , Silverman JM , Davis KL , Marin D , Grossman HZ , Schmeidler J , et al Type 2 Diabetes Is Negatively Associated With Alzheimer's Disease Neuropathology . The Journals of Gerontology Series A: Biological Sciences and Medical Sciences . 2005 ; 60 ( 4 ): 471 – 5 . doi: 10.1093/gerona/60.4.471

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Predicting dementia from primary care records: A systematic review and meta-analysis 원문보기

Abstract ▼ AI-Helper

참고문헌 (55)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트