$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies 원문보기

International journal of molecular sciences, v.21 no.2, 2020년, pp.493 -   

Zhang, Xiao-Wen ,  Chen, Jia-Yue ,  Ouyang, Defang ,  Lu, Jia-Hong

Abstract AI-Helper 아이콘AI-Helper

Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural fl...

주제어

참고문헌 (24)

  1. 1. Weller J. Budson A. Current understanding of Alzheimer’s disease diagnosis and treatment F1000Research 2018 7 10.12688/f1000research.14506.1 

  2. 2. Suganthy N. Devi K.P. Nabavi S.F. Braidy N. Nabavi S.M. Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions Biomed. Pharmacother. 2016 84 892 908 10.1016/j.biopha.2016.10.011 27756054 

  3. 3. Nakagawa T. Ohta K. Quercetin Regulates the Integrated Stress Response to Improve Memory Int. J. Mol. Sci. 2019 20 2761 10.3390/ijms20112761 31195662 

  4. 4. Chen J.Y. Zhu Q. Zhang S. OuYang D. Lu J.H. Resveratrol in experimental Alzheimer’s disease models: A systematic review of preclinical studies Pharmacol. Res. 2019 150 104476 10.1016/j.phrs.2019.104476 31605783 

  5. 5. Patil C.S. Singh V.P. Satyanarayan P.S. Jain N.K. Singh A. Kulkarni S.K. Protective effect of flavonoids against aging-and lipopolysaccharide-induced cognitive impairment in mice Pharmacology 2003 69 59 67 10.1159/000072357 12928578 

  6. 6. Wang D.M. Li S.Q. Wu W.L. Zhu X.Y. Wang Y. Yuan H.Y. Effects of long-term treatment with quercetin on cognition and mitochondrial function in a mouse model of Alzheimer’s disease Neurochem. Res. 2014 39 1533 1543 10.1007/s11064-014-1343-x 24893798 

  7. 7. Hayakawa M. Itoh M. Ohta K. Li S. Ueda M. Wang M.X. Nishida E. Islam S. Suzuki C. Ohzawa K. Quercetin reduces eIF2α phosphorylation by GADD34 induction Neurobiol. Aging 2015 36 2509 2518 10.1016/j.neurobiolaging.2015.05.006 26070242 

  8. 8. Sabogal-Guaqueta A.M. Munoz-Manco J.I. Ramirez-Pineda J.R. Lamprea-Rodriguez M. Osorio E. Cardona-Gomez G.P. The flavonoid quercetin ameliorates Alzheimer’s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer’s disease model mice Neuropharmacology 2015 93 134 145 10.1016/j.neuropharm.2015.01.027 25666032 

  9. 9. Zhang X. Hu J. Zhong L. Wang N. Yang L. Liu C.C. Li H. Wang X. Zhou Y. Zhang Y. Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice Neuropharmacology 2016 108 179 192 10.1016/j.neuropharm.2016.04.032 27114256 

  10. 10. Sun D. Li N. Zhang W. Zhao Z. Mou Z. Huang D. Liu J. Wang W. Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer’s disease Colloids Surf. B Biointerfaces 2016 148 116 129 10.1016/j.colsurfb.2016.08.052 27591943 

  11. 11. Puerta E. Suarez-Santiago J.E. Santos-Magalhaes N.S. Ramirez M.J. Irache J.M. Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease Int. J. Pharm. 2017 517 50 57 27915007 

  12. 12. Vargas-Restrepo F. Sabogal-Guaqueta A.M. Cardona-Gomez G.P. Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer’ s disease mice model Biomedica 2018 38 62 69 10.7705/biomedica.v38i0.3761 29809330 

  13. 13. Khan A. Ali T. Rehman S.U. Khan M.S. Alam S.I. Ikram M. Muhammad T. Saeed K. Badshah H. Kim M.O. Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain Front. Pharmacol. 2018 9 10.3389/fphar.2018.01383 

  14. 14. Rishitha N. Muthuraman A. Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish Life Sci. 2018 199 80 87 10.1016/j.lfs.2018.03.010 29522770 

  15. 15. Lu Y. Liu Q. Yu Q. Quercetin enrich diet during the early-middle not middle-late stage of alzheimer’s disease ameliorates cognitive dysfunction Am. J. Transl. Res. 2018 10 1237 29736217 

  16. 16. Karimipour M. Rahbarghazi R. Tayefi H. Shimia M. Ghanadian M. Mahmoudi J. Bagheri H.S. Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus Int. J. Dev. Neurosci. 2019 74 18 26 10.1016/j.ijdevneu.2019.02.005 30822517 

  17. 17. Paula P.C. Angelica Maria S.G. Luis C.H. Gloria Patricia C.G. Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model Molecules 2019 24 2287 10.3390/molecules24122287 

  18. 18. Li Y. Tian Q. Li Z. Dang M. Lin Y. Hou X. Activation of Nrf2 signaling by sitagliptin and quercetin combination against β-amyloid induced Alzheimer’s disease in rats Drug Dev. Res. 2019 80 837 845 10.1002/ddr.21567 31301179 

  19. 19. Hooijmans C.R. Rovers M.M. de Vries R.B. Leenaars M. Ritskes-Hoitinga M. Langendam M.W. SYRCLE’s risk of bias tool for animal studies Bmc Med Res. Methodol. 2014 14 43 10.1186/1471-2288-14-43 24667063 

  20. 20. Habtemariam S. Rutin as a natural therapy for Alzheimer’s disease: Insights into its mechanisms of action Curr. Med. Chem. 2016 23 860 873 10.2174/0929867323666160217124333 26898570 

  21. 21. Zhu Q. Zhuang X. Lu J. Neuroprotective effects of baicalein in animal models of Parkinson’s disease: A systematic review of experimental studies Phytomedicine 2019 55 302 309 10.1016/j.phymed.2018.09.215 30385133 

  22. 22. Elder G.A. Gama Sosa M.A. De Gasperi R. Mouse models of Alzheimer’s disease J. Alzheimer’s Dis. 2017 57 1171 1183 28304309 

  23. 23. Men K. Duan X. Wei X.W. Gou M.L. Huang M.J. Chen L.J. Qian Z.Y. Wei Y.Q. Nanoparticle-delivered quercetin for cancer therapy Anti-Cancer Agents Med. Chem. 2014 14 826 832 10.2174/1871520614666140521122932 24851877 

  24. 24. Zaplatic E. Bule M. Shah S.Z.A. Uddin M.S. Niaz K. Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer’s disease Life Sci. 2019 10.1016/j.lfs.2019.03.055 30914316 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로