[논문]Distinct effects of reward and navigation history on hippocampal forward and reverse replays

Bhattarai, Baburam; Lee, Jong Won; Jung, Min Whan

doi:10.1073/pnas.1912533117

[해외논문] Distinct effects of reward and navigation history on hippocampal forward and reverse replays 원문보기

Proceedings of the National Academy of Sciences of the United States of America, v.117 no.1, 2020년, pp.689 - 697

Bhattarai, Baburam (Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 34141 Daejeon, Korea) , Lee, Jong Won , Jung, Min Whan (Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 34141 Daejeon, Korea)

Abstract ▼ AI-Helper

SignificanceSequential firing patterns of hippocampal place cells during spatial navigation are replayed in both forward and reverse directions during offline idling states, but functional roles of these replays are not clearly understood. To clarify this matter, we examined hippocampal replays in a spatial sequence memory task. We found that reward increases the fidelity of forward replays, while increasing the rate of reverse replays for all possible trajectories heading toward a rewarding location. We also found more faithful reactivation of place-cell sequences for upcoming rewarding trajectories than for already rewarded trajectories in forward replays. Our results suggest that hippocampal forward and reverse replays contribute to constructing a map of potential navigation trajectories with associated values (“value map”) via distinct mechanisms.To better understand the functional roles of hippocampal forward and reverse replays, we trained rats in a spatial sequence memory task and examined how these replays are modulated by reward and navigation history. We found that reward enhances both forward and reverse replays during the awake state, but in different ways. Reward enhances the rate of reverse replays, but it increases the fidelity of forward replays for recently traveled as well as other alternative trajectories heading toward a rewarding location. This suggests roles for forward and reverse replays in reinforcing representations for all potential rewarding trajectories. We also found more faithful reactivation of upcoming than already rewarded trajectories in forward replays. This suggests a role for forward replays in preferentially reinforcing representations for high-value trajectories. We propose that hippocampal forward and reverse replays might contribute to constructing a map of potential navigation trajectories and their associated values (a “value map”) via distinct mechanisms.

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