[논문]FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals

Kang, Hyo Jung; Yoon, Sujung; Lee, Suji; Choi, Koeul; Seol, Sihwan; Park, Shinwon; Namgung, Eun; Kim, Tammy D.; Chung, Yong-An; Kim, Jungyoon; Han, Jung-Soo; Lyoo, In Kyoon

doi:10.1038/s41598-020-60334-6

FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals 원문보기

Scientific reports, v.10, 2020년, pp.3353 -

Kang, Hyo Jung (Department of Life Science, Chung-Ang University, Seoul, South Korea) , Yoon, Sujung (Ewha Brain Institute, Ewha W. University, Seoul, South Korea) , Lee, Suji (Ewha Brain Institute, Ewha W. University, Seoul, South Korea) , Choi, Koeul (Department of Life Science, Chung-Ang University, Seoul, South Korea) , Seol, Sihwan (Department of Life Science, Chung-Ang University, Seoul, South Korea) , Park, Shinwon (Ewha Brain Institute, Ewha W. University, Seoul, South Korea) , Namgung, Eun (Ewha Brain Institute, Ewha W. University, Seoul, South Korea) , Kim, Tammy D. (Ewha Brain Institute, Ewha W. University, Seoul, South Korea) , Chung, Yong-An (Department of Radiology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea) , Kim, Jungyoon (Ewha Brain Institute, Ewha W. University, Seoul, South Korea) , Han, Jung-Soo (Department of Biological Sciences, Konkuk University, Seoul, South Korea) , Lyoo, In Kyoon (Ewha Brain Institute, Ewha W. University, Seoul, South Korea)

Abstract ▼ AI-Helper

The epigenetic regulation of microRNA (miRNA) expression related to the FK506-binding protein 5 (FKBP5) gene may contribute to the risk of stress-related disorders such as posttraumatic stress disorder (PTSD). Here, we identified candidate miRNAs derived from FKBP5 knockout mice as a potential diagnostic biomarker of PTSD. Using a translational approach, candidate miRNAs found to alter in expression within the medial prefrontal cortex of FKBP5 knockout mice were selected. Each candidate miRNA was examined in the serum of 48 recently traumatized individuals with PTSD and 47 healthy individuals. Multimodal imaging was also conducted to identify the neural correlates for the expression of candidate exosomal miRNAs in response to trauma exposure. Differential miRNA expression was found according to PTSD diagnosis in two composite marker groups. The differential miRNA expression between the composite marker groups contributed to PTSD symptom severity, which may be explained by differential recruitment of prefrontolimbic activity in brain imaging. The present study reveals that a set of circulating exosomal miRNAs showing altered expression in FKBP5 knockout mice play a potential role as epigenetic markers of PTSD. The corroborative evidence from multiple levels including molecular, brain, and behavioral indicates that these epigenetic biomarkers may serve as complementary measures for the diagnosis and prognosis prediction of PTSD in recently traumatized individuals.

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FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals 원문보기

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FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals 원문보기

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