$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] PRMT1 Is Required for the Maintenance of Mature β-Cell Identity 원문보기

Diabetes, v.69 no.3, 2020년, pp.355 - 368  

Kim, Hyunki (1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea) ,  Yoon, Byoung-Ha (2Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) ,  Oh, Chang-Myung (4Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea) ,  Lee, Joonyub (1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea) ,  Lee, Kanghoon (1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea) ,  Song, Heein (1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea) ,  Kim, Eunha (5Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea) ,  Yi, Kijong (1<) ,  Kim, Mi-Young ,  Kim, Hyeongseok ,  Kim, Yong Kyung ,  Seo, Eun-Hye ,  Heo, Haejeong ,  Kim, Hee-Jin ,  Lee, Junguee ,  Suh, Jae Myoung ,  Koo, Seung-Hoi ,  Seong, Je Kyung ,  Kim, Seyun ,  Ju, Young Seok ,  Shong, Minho ,  Kim, Mirang ,  Kim, Hail

Abstract AI-Helper 아이콘AI-Helper

Loss of functional β-cell mass is an essential feature of type 2 diabetes, and maintaining mature β-cell identity is important for preserving a functional β-cell mass. However, it is unclear how β-cells achieve and maintain their mature identity. Here we demonstrate a nov...

참고문헌 (54)

  1. 10.2337/dc14-0396 Halban PA, Polonsky KS, Bowden DW, et al. β-Cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care 2014;37:1751-1758 

  2. J Clin Invest Prentki 116 1802 2006 10.1172/JCI29103 Islet β cell failure in type 2 diabetes 

  3. 10.2337/diabetes.54.suppl_2.S108 Donath MY, Ehses JA, Maedler K, et al. Mechanisms of β-cell death in type 2 diabetes. Diabetes 2005;54(Suppl. 2):S108-S113 

  4. Cell Talchai 150 1223 2012 10.1016/j.cell.2012.07.029 Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure 

  5. Diabetes Obes Metab Cigliola 18 87 2016 10.1111/dom.12726 Stress-induced adaptive islet cell identity changes 

  6. Diabetologia Nishimura 58 566 2015 10.1007/s00125-014-3464-9 MafA is critical for maintenance of the mature beta cell phenotype in mice 

  7. Cell Metab Gu 11 298 2010 10.1016/j.cmet.2010.03.006 Pancreatic β cells require NeuroD to achieve and maintain functional maturity 

  8. J Clin Invest Swisa 127 230 2017 10.1172/JCI88015 PAX6 maintains β cell identity by repressing genes of alternative islet cell types 

  9. J Clin Invest Ediger 127 215 2017 10.1172/JCI88016 LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells 

  10. J Clin Invest Gutiérrez 127 244 2017 10.1172/JCI88017 Pancreatic β cell identity requires continual repression of non-β cell programs 

  11. Nature Dixon 518 331 2015 10.1038/nature14222 Chromatin architecture reorganization during stem cell differentiation 

  12. Nature Ernst 473 43 2011 10.1038/nature09906 Mapping and analysis of chromatin state dynamics in nine human cell types 

  13. Trends Endocrinol Metab Campbell 27 142 2016 10.1016/j.tem.2015.12.005 Chromatin regulators in pancreas development and diabetes 

  14. Cell Metab Avrahami 22 619 2015 10.1016/j.cmet.2015.07.025 Aging-dependent demethylation of regulatory elements correlates with chromatin state and improved β cell function 

  15. Cell Metab Arda 23 909 2016 10.1016/j.cmet.2016.04.002 Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function 

  16. Cell Metab Lu 27 1294 2018 10.1016/j.cmet.2018.04.013 The polycomb-dependent epigenome controls β cell dysfunction, dedifferentiation, and diabetes 

  17. FEBS Lett Di Lorenzo 585 2024 2011 10.1016/j.febslet.2010.11.010 Histone arginine methylation 

  18. Mol Cell Blanc 65 8 2017 10.1016/j.molcel.2016.11.003 Arginine methylation: the coming of age 

  19. 10.1530/JME-14-0325 Kim JK, Lim Y, Lee JO, et al. PRMT4 is involved in insulin secretion via methylation of histone H3 in pancreatic β cells. J Mol Endocrinol 2015;54:315-324 

  20. J Biol Chem Tang 275 7723 2000 10.1074/jbc.275.11.7723 PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells 

  21. Life Sci Iwasaki 85 161 2009 10.1016/j.lfs.2009.05.007 Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto-Kakizaki rats 

  22. Science Wang 293 853 2001 10.1126/science.1060781 Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor 

  23. Genes Dev Huang 19 1885 2005 10.1101/gad.1333905 Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications 

  24. Endocrinology Kim 156 444 2015 10.1210/en.2014-1687 Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state 

  25. J Vis Exp Szot 7 255 2007 Murine pancreatic islet isolation 

  26. Oncotarget Baek 7 25620 2016 10.18632/oncotarget.8239 Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer 

  27. Curr Protoc Mol Biol Buenrostro 21.29.1 2015 ATAC-seq: a method for assaying chromatin accessibility genome-wide 

  28. Nat Protoc Hagège 2 1722 2007 10.1038/nprot.2007.243 Quantitative analysis of chromosome conformation capture assays (3C-qPCR) 

  29. Cell Tang 163 1611 2015 10.1016/j.cell.2015.11.024 CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription 

  30. Nat Rev Genet Ong 15 234 2014 10.1038/nrg3663 CTCF: an architectural protein bridging genome topology and function 

  31. J Clin Invest Dhawan 125 2851 2015 10.1172/JCI79956 DNA methylation directs functional maturation of pancreatic β cells 

  32. Cell Metab Yoshihara 23 622 2016 10.1016/j.cmet.2016.03.005 ERRγ is required for the metabolic maturation of therapeutically functional glucose-responsive β cells 

  33. Diabetes Obes Metab Pullen 15 503 2013 10.1111/dom.12029 When less is more: the forbidden fruits of gene repression in the adult β-cell 

  34. Diabetologia Marchetti 50 2486 2007 10.1007/s00125-007-0816-8 The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients 

  35. Diabetes Metab Res Rev Masini 33 e2894 2017 10.1002/dmrr.2894 Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus 

  36. 10.2337/diabetes.53.suppl_3.S16 Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 2004;53(Suppl. 3):S16-S21 

  37. J Clin Invest Guo 123 3305 2013 10.1172/JCI65390 Inactivation of specific β cell transcription factors in type 2 diabetes 

  38. J Clin Endocrinol Metab Cinti 101 1044 2016 10.1210/jc.2015-2860 Evidence of β-cell dedifferentiation in human type 2 diabetes 

  39. Cell Dowen 159 374 2014 10.1016/j.cell.2014.09.030 Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes 

  40. 10.2337/db16-1516 Spaeth JM, Gupte M, Perelis M, et al. Defining a novel role for the Pdx1 transcription factor in islet β-cell maturation and proliferation during weaning. Diabetes 2017;66:2830-2839 

  41. J Biol Chem Brissova 277 11225 2002 10.1074/jbc.M111272200 Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion 

  42. Cell Metab Gauthier 10 110 2009 10.1016/j.cmet.2009.07.002 PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression 

  43. 10.1073/pnas.0914209107 Fujimoto K, Chen Y, Polonsky KS, Dorn GW. Targeting cyclophilin D and the mitochondrial permeability transition enhances β-cell survival and prevents diabetes in Pdx1 deficiency. Proc Natl Acad Sci U S A 2010;107:10214-10219 

  44. 10.2337/db15-0376 Soleimanpour SA, Ferrari AM, Raum JC, et al. Diabetes susceptibility genes Pdx1 and Clec16a function in a pathway regulating mitophagy in β-cells. Diabetes 2015;64:3475-3484 

  45. PLoS Med Wheeler 14 e1002383 2017 10.1371/journal.pmed.1002383 Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: a transethnic genome-wide meta-analysis 

  46. Diabetologia Rutter 58 31 2015 10.1007/s00125-014-3405-7 SLC30A8 mutations in type 2 diabetes 

  47. Nat Genet Zhao 49 1450 2017 10.1038/ng.3943 Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease 

  48. Nat Genet Mahajan 46 234 2014 10.1038/ng.2897 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility 

  49. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants. Science 2007;316:1341-1345 

  50. PLoS Genet Tsai 6 e1000847 2010 10.1371/journal.pgen.1000847 A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese 

  51. J Clin Endocrinol Metab Brunzell 42 222 1976 10.1210/jcem-42-2-222 Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests 

  52. Mol Cell Yamagata 32 221 2008 10.1016/j.molcel.2008.09.013 Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt 

  53. Mol Cell Barrero 24 233 2006 10.1016/j.molcel.2006.09.020 Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation 

  54. J Biol Chem Miura 281 5246 2006 10.1074/jbc.M507496200 Hepatocyte nuclear factor-4α is essential for glucose-stimulated insulin secretion by pancreatic β-cells 

LOADING...

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

원문 보기

원문 URL 링크

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

유발과제정보 저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로