$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Towards manufacturing of human organoids

Biotechnology advances, v.39, 2020년, pp.107460 -   

Ashok, Aswathi (Bio-Manufacturing Programme, Singapore Institute of Manufacturing Technology (SIMTech), Agency for Science, Technology and Research (A*STAR)) ,  Choudhury, Deepak (Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos) ,  Fang, Yu (Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos) ,  Hunziker, Walter (Bio-Manufacturing Programme, Singapore Institute of Manufacturing Technology (SIMTech), Agency for Science, Technology and Research (A*STAR))

Abstract AI-Helper 아이콘AI-Helper

Abstract Organoids are 3D miniature versions of organs produced from stem cells derived from either patient or healthy individuals in vitro that recapitulate the actual organ. Organoid technology has ensured an alternative to pre-clinical drug testing as well as being currently used for “pers...

Keyword

참고문헌 (186)

  1. Bioessays Akkerman 39 4 2017 10.1002/bies.201600244 Dawn of the organoid era: 3D tissue and organ cultures revolutionize the study of development, disease, and regeneration 

  2. Stem Cells Int. Allenby 2018 2018 10.1155/2018/6230214 Ceramic hollow fibre constructs for continuous perfusion and cell harvest from 3d hematopoietic organoids 

  3. Nat. Rev. Nephrol. Allison 15 5 254 2019 Fluid flow enhances vascularization and maturation of kidney organoids 

  4. Nature Antonica 491 66 2012 10.1038/nature11525 Generation of functional thyroid from embryonic stem cells 

  5. Development Arora 144 6 1128 2017 10.1242/dev.142919 A process engineering approach to increase organoid yield 

  6. Nat. Methods Bagley 14 7 743 2017 10.1038/nmeth.4304 Fused cerebral organoids model interactions between brain regions 

  7. J. Cyst. Fibros. Bals 3 Suppl. 2 49 2004 10.1016/j.jcf.2004.05.010 Isolation and air-liquid interface culture of human large airway and bronchiolar epithelial cells 

  8. Cell Stem Cell Barker 6 1 25 2010 10.1016/j.stem.2009.11.013 Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro 

  9. J. Vis. Exp. Bartfeld 105 53359 2015 Organoids as model for infectious diseases: culture of human and murine stomach organoids and microinjection of helicobacter pylori 

  10. J. Mol. Med. Bartfeld 1432 2017 Stem cell-derived organoids and their application for medical research and patient treatment 

  11. Gastroenterology Bartfeld 148 1 126 2015 10.1053/j.gastro.2014.09.042 In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection 

  12. Bello 

  13. J. Cell. Physiol. Benton 221 18 2009 10.1002/jcp.21832 Advancing science and technology via 3D culture on basement membrane matrix 

  14. Int. J. Cancer Benton 128 1751 2011 10.1002/ijc.25781 Multiple uses of basement membrane-like matrix (BME/matrigel) in vitro and in vivo with cancer cells 

  15. Nat. Biotechnol. Bhatia 32 760 2014 10.1038/nbt.2989 Microfluidic organs-on-chips 

  16. Boettner 

  17. Boucherie 31 408 2013 Brief Report: Self-Organizing Neuroepithelium From Human Pluripotent Stem Cells Facilitates Derivation of Photoreceptors 

  18. Dev. Cell Braverman 44 5 533 2018 10.1016/j.devcel.2018.02.016 From 3D organoids back to 2D enteroids 

  19. Nat. Protoc. Broutier 11 9 1724 2016 10.1038/nprot.2016.097 Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation 

  20. Nat. Med. Broutier 23 1424 2017 10.1038/nm.4438 Human primary liver cancer-derived organoid cultures for disease modeling and drug screening 

  21. Virus Res. Campo 89 2 249 2002 10.1016/S0168-1702(02)00193-4 Animal models of papillomavirus pathogenesis 

  22. Infect. Immun. Castellanos-Gonzalez 81 6 1996 2013 10.1128/IAI.01131-12 Human primary intestinal epithelial cells as an improved in vitro model for cryptosporidium parvum infection 

  23. Nat. Med. Chakradhar 22 338 2016 10.1038/nm0416-338 New company aims to broaden researchers' access to organoids 

  24. Int. J. Bioprinting Choudhury 4 2 2018 10.18063/ijb.v4i2.139 The arrival of commercial bioprinters - towards 3d bioprinting revolution! 

  25. Trends Biotechnol. Choudhury 36 8 787 2018 10.1016/j.tibtech.2018.03.003 Organ-derived decellularized extracellular matrix: a game changer for bioink manufacturing? 

  26. Science Cohen 360 6395 1284 2018 10.1126/science.360.6395.1284 Neanderthal brain organoids come to life 

  27. Biotechnol. Adv. Costa 34 8 1427 2016 10.1016/j.biotechadv.2016.11.002 3D tumor spheroids: an overview on the tools and techniques used for their analysis 

  28. Nat. Med. Crespo 23 7 878 2017 10.1038/nm.4355 Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing 

  29. Nature Cugola 534 7606 267 2016 10.1038/nature18296 The brazilian zika virus strain causes birth defects in experimental models 

  30. Stem Cells Int. Dakhore 2018 2018 10.1155/2018/7396905 Human pluripotent stem cell culture: current status, challenges, and advancement 

  31. Nat. Biotechnol. D'Amour 23 12 1534 2005 10.1038/nbt1163 Efficient differentiation of human embryonic stem cells to definitive endoderm 

  32. Tissue Eng. C Daquinag 19 5 336 2012 10.1089/ten.tec.2012.0198 Adipose tissue engineering in three-dimensional levitation tissue culture system based on magnetic nanoparticles 

  33. Nat. Rev. Cancer Dart 19 3 126 2019 Organoid 2.0 

  34. Nat. Med. Dekkers 19 7 939 2013 10.1038/nm.3201 A functional CFTR assay using primary cystic fibrosis intestinal organoids 

  35. BMC Cell Biol. Delgado-Ortega 15 2014 10.1186/1471-2121-15-14 Newborn pig trachea cell line cultured in air-liquid interface conditions allows a partial in vitro representation of the porcine upper airway tissue 

  36. Curr. Protoc. Pharmacol. DeRose 60 14.23.1 2013 10.1002/0471141755.ph1423s60 Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine 

  37. Integr. Biol. DiMarco 6 2 127 2014 10.1039/C3IB40188J Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids 

  38. Stem Cell Rep. DiStefano 10 1 300 2018 10.1016/j.stemcr.2017.11.001 Accelerated and improved differentiation of retinal organoids from pluripotent stem cells in rotating-wall vessel bioreactors 

  39. Am. J. Physiol. Gastrointest. Liver Physiol. Driehuis 312 3 G257 2017 10.1152/ajpgi.00410.2016 CRISPR/Cas 9 genome editing and its applications in organoids 

  40. Nat. Rev. Cancer Drost 18 7 407 2018 10.1038/s41568-018-0007-6 Organoids in cancer research 

  41. Science Drost 358 6360 234 2017 10.1126/science.aao3130 Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer 

  42. Trends Mol. Med. Dutta 23 5 393 2017 10.1016/j.molmed.2017.02.007 Disease modeling in stem cell-derived 3d organoid systems 

  43. Elife Dye 4 2015 10.7554/eLife.05098 In vitro generation of human pluripotent stem cell derived lung organoids 

  44. Cell. Mol. Gastroenterol. Hepatol. Eicher 5 3 353 2018 10.1016/j.jcmgh.2017.12.014 Translating developmental principles to generate human gastric organoids 

  45. Cell Stem Cell Eiraku 3 5 519 2008 10.1016/j.stem.2008.09.002 Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals 

  46. Nature Eiraku 472 51 2011 10.1038/nature09941 Self-organizing optic-cup morphogenesis in three-dimensional culture 

  47. J Gen Virol Escaffre 97 5 1077 2016 10.1099/jgv.0.000441 Characterization of Nipah virus infection in a model of human airway epithelial cells cultured at an air-liquid interface 

  48. Science (N.Y. N.Y.) Ettayebi 353 6306 1387 2016 10.1126/science.aaf5211 Replication of human noroviruses in stem cell-derived human enteroids 

  49. Nat. Cell Biol. Fatehullah 18 3 246 2016 10.1038/ncb3312 Organoids as an in vitro model of human development and disease 

  50. Cytotherapy Fatimah 15 8 1030 2013 10.1016/j.jcyt.2013.05.003 Organotypic culture of human amnion cells in air-liquid interface as a potential substitute for skin regeneration 

  51. J. Tissue Eng. Regen. Med. Ferreira 0 0 2019 A magnetic three-dimensional levitated primary cell culture system for the development of secretory salivary gland-like organoids 

  52. Eur. Respir. J. Fessart 42 5 1345 2013 10.1183/09031936.00118812 Three-dimensional culture model to distinguish normal from malignant human bronchial epithelial cells 

  53. mBio Finkbeiner 3 4 e00112 2012 10.1128/mBio.00159-12 Stem cell-derived human intestinal organoids as an infection model for rotaviruses 

  54. Gastroenterology Foulke-Abel 150 3 638 2016 10.1053/j.gastro.2015.11.047 Human enteroids as a model of upper small intestinal ion transport physiology and pathophysiology 

  55. Nat. Commun. Freedman 6 8715 2015 10.1038/ncomms9715 Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids 

  56. EMBO J. Gabriel 35 8 803 2016 10.15252/embj.201593679 CPAP promotes timely cilium disassembly to maintain neural progenitor pool 

  57. Cell Gao 159 1 176 2014 10.1016/j.cell.2014.08.016 Organoid cultures derived from patients with advanced prostate cancer 

  58. Gao 1097 2014 Organoid Cultures Derived from Patients With Advanced Prostate Cancer 

  59. Science Garcez 352 6287 816 2016 10.1126/science.aaf6116 Zika virus impairs growth in human neurospheres and brain organoids 

  60. Giandomenico 2018 Cerebral Organoids at the Air-Liquid Interface Generate Diverse Nerve Tracts With Functional Output 

  61. Brain Gold 129 8 1953 2006 10.1093/brain/awl075 Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research 

  62. Dev. (Camb. Engl.) Greggio 140 21 4452 2013 10.1242/dev.096628 Artificial three-dimensional niches deconstruct pancreas development in vitro 

  63. Development Haegel 121 11 3529 1995 10.1242/dev.121.11.3529 Lack of beta-catenin affects mouse development at gastrulation 

  64. Sci. Rep. Hisha 3 3224 2013 10.1038/srep03224 Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells 

  65. Gut Hohwieler 66 3 473 2017 10.1136/gutjnl-2016-312423 Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling 

  66. Nat. Methods Homan 16 3 255 2019 10.1038/s41592-019-0325-y Flow-enhanced vascularization and maturation of kidney organoids in vitro 

  67. Mol. Endocrinol. Hsu 12 12 1830 1998 10.1210/mend.12.12.0211 Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a g protein-coupled, seven-transmembrane region 

  68. Nat. Med. Huang 21 1364 2015 10.1038/nm.3973 Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids 

  69. Development Huch 142 18 3113 2015 10.1242/dev.118570 Modeling mouse and human development using organoid cultures 

  70. Future Medicine, Regenerative Medicine Huch 8 385 2013 10.2217/rme.13.39 Lgr5(+) Liver Stem Cells, Hepatic Organoids and Regenerative Medicine 

  71. Nature Huch 494 247 2013 10.1038/nature11826 In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration 

  72. Huch 1477 2017 The hope and the hype of organoid research 

  73. Hughes 10 1886 2010 Matrigel: a Complex Protein Mixture Required for Optimal Growth of Cell Culture 

  74. Trends Cell Biol. Huh 21 12 745 2011 10.1016/j.tcb.2011.09.005 From 3D cell culture to organs-on-chips 

  75. Hui 2007 Micromechanical Control of Cell-Cell Interactions 

  76. J. Pathol. Hwang 238 2 197 2016 10.1002/path.4651 Preclinical models of pancreatic ductal adenocarcinoma 

  77. Nat. Rev. Drug Discov. Kamb 6 115 2006 10.1038/nrd2155 Why is cancer drug discovery so difficult? 

  78. Kang 179 2015 Essentials of 3D Biofabrication and Translation Chapter 10 - bioprinting of organs for toxicology testing 

  79. Stem Cells Kaushik 36 9 1329 2018 10.1002/stem.2852 Concise review: current status of three-dimensional organoids as preclinical models 

  80. Kelava 18 736 2016 Stem Cell Models of Human Brain Development 

  81. Viruses Kim 11 2 124 2019 10.3390/v11020124 Modeling host-virus interactions in viral infectious diseases using stem-cell-derived systems and CRISPR/Cas9 technology 

  82. Drug Metab. Pharmacokinet. Kimura 33 1 43 2018 10.1016/j.dmpk.2017.11.003 Organ/body-on-a-chip based on microfluidic technology for drug discovery 

  83. Nature Koehler 500 217 2013 10.1038/nature12298 Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture 

  84. Cytotechnology Koike 47 1-3 3 2005 10.1007/s10616-005-3743-x A round-bottom 96-well polystyrene plate coated with 2-methacryloyloxyethyl phosphorylcholine as an effective tool for embryoid body formation 

  85. Nat. Med. Kopper 25 5 838 2019 10.1038/s41591-019-0422-6 An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity 

  86. J. Vis. Exp. Krefft 131 2018 10.3791/56768 Generation of standardized and reproducible forebrain-type cerebral organoids from human induced pluripotent stem cells 

  87. Nat. Biotechnol. Lancaster 36 5 407 2018 10.1038/nbt.4133 Brain organoids get vascularized 

  88. Nat. Protoc. Lancaster 9 10 2329 2014 10.1038/nprot.2014.158 Generation of cerebral organoids from human pluripotent stem cells 

  89. Science Lancaster 345 6194 2014 10.1126/science.1247125 Organogenesis in a dish: modeling development and disease using organoid technologies 

  90. Nature Lancaster 501 373 2013 10.1038/nature12517 Cerebral organoids model human brain development and microcephaly 

  91. Cell Host Microbe Lazear 19 5 720 2016 10.1016/j.chom.2016.03.010 A mouse model of zika virus pathogenesis 

  92. Nat. Methods Lee 4 359 2007 10.1038/nmeth1015 Three-dimensional culture models of normal and malignant breast epithelial cells 

  93. Tissue Eng. C. Lee 20 6 473 2013 10.1089/ten.tec.2013.0335 Design and fabrication of human skin by three-dimensional bioprinting 

  94. Cell Lee 173 2 515 2018 10.1016/j.cell.2018.03.017 Tumor evolution and drug response in patient-derived organoid models of bladder cancer 

  95. Li 

  96. Nat. Med. Li 20 7 769 2014 10.1038/nm.3585 Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture 

  97. Nat. Med. Li 20 769 2014 10.1038/nm.3585 Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture 

  98. Methods Mol. Biol. Li 1422 33 2016 10.1007/978-1-4939-3603-8_4 An air-liquid interface culture system for 3d organoid culture of diverse primary gastrointestinal tissues 

  99. Neurosci. Res. Notes Ling 2 1 1 2019 10.31117/neuroscirn.v1i1.4 Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders 

  100. Nat. Genet. Liu 22 361 1999 10.1038/11932 Requirement for Wnt3 in vertebrate axis formation 

  101. Cell Discov. Liu 4 32 2018 10.1038/s41421-018-0036-z Monolayer culture of intestinal epithelium sustains Lgr5(+) intestinal stem cells 

  102. Nat. Rev. Genet. Lokody 15 63 2013 10.1038/nrg3656 Correcting genetic defects with CRISPR-Cas9 

  103. Adv Biosyst. Lu 1 12 2017 10.1002/adbi.201700165 Scalable production and cryostorage of organoids using core-shell decoupled hydrogel capsules 

  104. Stem Cell Rep. Maimets 6 1 150 2016 10.1016/j.stemcr.2015.11.009 Long-term in vitro expansion of salivary gland stem cells driven by wnt signals 

  105. Nat. Biotechnol. Mansour 36 5 432 2018 10.1038/nbt.4127 An in vivo model of functional and vascularized human brain organoids 

  106. Cell Mariani 162 2 375 2015 10.1016/j.cell.2015.06.034 FOXG1-Dependent dysregulation of GABA/Glutamate neuron differentiation in autism spectrum disorders 

  107. Nat. Med. Matano 21 256 2015 10.1038/nm.3802 Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids 

  108. Nature McCracken 516 400 2014 10.1038/nature13863 Modelling human development and disease in pluripotent stem-cell-derived gastric organoids 

  109. McMurtrey 1937 2016 Analytic Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids 

  110. Merck 

  111. J. Hepato-Biliary-Pancreat. Surg. Mitaka 9 6 697 2002 10.1007/s005340200096 Reconstruction of hepatic organoid by hepatic stem cells 

  112. Nat. Protoc. Morizane 12 1 195 2017 10.1038/nprot.2016.170 Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells 

  113. Cell Rep. Muguruma 10 4 537 2015 10.1016/j.celrep.2014.12.051 Self-organization of polarized cerebellar tissue in 3d culture of human pluripotent stem cells 

  114. Biochem. Biophys. Res. Commun. Nadkarni 473 3 675 2016 10.1016/j.bbrc.2015.12.091 Organoids as a model system for studying human lung development and disease 

  115. Int. Immunol. Nakamura 31 1 13 2019 10.1093/intimm/dxy065 Recent progress in organoid culture to model intestinal epithelial barrier functions 

  116. Stem Cell Rep. Nanduri 3 6 957 2014 10.1016/j.stemcr.2014.09.015 Purification and ex vivo expansion of fully functional salivary gland stem cells 

  117. Cell Neal 175 7 1972 2018 10.1016/j.cell.2018.11.021 Organoid modeling of the tumor immune microenvironment 

  118. EMBO Rep. Nie 18 3 367 2017 10.15252/embr.201643732 Organoid technologies meet genome engineering 

  119. Curr. Opin. Pulm. Med. Noordhoek 22 6 610 2016 10.1097/MCP.0000000000000315 Intestinal organoids and personalized medicine in cystic fibrosis: a successful patient-oriented research collaboration 

  120. Clin. Pharmacol. Ther. Nugraha 105 1 79 2019 10.1002/cpt.1286 Human cardiac organoids for disease modeling 

  121. Nat. Med. Ootani 15 6 701 2009 10.1038/nm.1951 Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche 

  122. Bio. Protoc. O'Rourke 6 4 2016 Isolation, culture, and maintenance of mouse intestinal stem cells 

  123. Nat. Biotechnol. O'Rourke 35 6 577 2017 10.1038/nbt.3837 Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer 

  124. Biomaterials Pageau 32 29 7169 2011 10.1016/j.biomaterials.2011.06.017 The effect of stromal components on the modulation of the phenotype of human bronchial epithelial cells in 3D culture 

  125. Science Paşca 363 6423 126 2019 10.1126/science.aau5729 Assembling human brain organoids 

  126. mBio Porotto 10 3 e00719 2019 10.1128/mBio.00723-19 Authentic modeling of human respiratory virus infection in human pluripotent stem cell-derived lung organoids 

  127. J. Investig. Dermatol. Pruniéras 81 1 S28 1983 10.1111/1523-1747.ep12540324 Methods for cultivation of keratinocytes with an air-liquid interface 

  128. Curr. Opin. Biotechnol. Purcell 29 146 2014 10.1016/j.copbio.2014.04.009 Synthetic analog and digital circuits for cellular computation and memory 

  129. Cell Qian 165 5 1238 2016 10.1016/j.cell.2016.04.032 Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure 

  130. Nature Quadrato 545 7652 48 2017 10.1038/nature22047 Cell diversity and network dynamics in photosensitive human brain organoids 

  131. Research 

  132. Nat. Rev. Genet. Rossi 19 11 671 2018 10.1038/s41576-018-0051-9 Progress and potential in organoid research 

  133. Cell Sachs 172 1 373 2018 10.1016/j.cell.2017.11.010 A living biobank of breast cancer organoids captures disease heterogeneity 

  134. Gene Saglam-Metiner 686 203 2019 10.1016/j.gene.2018.11.058 Bioengineering-inspired three-dimensional culture systems: organoids to create tumor microenvironment 

  135. Science Sato 340 6137 1190 2013 10.1126/science.1234852 Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications 

  136. Nature Sato 459 7244 262 2009 10.1038/nature07935 Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche 

  137. Nature Sato 469 415 2010 10.1038/nature09637 Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts 

  138. Gastroenterology Sato 141 5 1762 2011 10.1053/j.gastro.2011.07.050 Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium 

  139. Cell Stem Cell Schwank 13 6 653 2013 10.1016/j.stem.2013.11.002 Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients 

  140. Gut Seidlitz 68 2 207 2019 10.1136/gutjnl-2017-314549 Human gastric cancer modelling using organoids 

  141. BMC Biomed. Eng. Sekiya 1 1 15 2019 10.1186/s42490-019-0017-9 Perfusion culture maintained with an air-liquid interface to stimulate epithelial cell organization in renal organoids in vitro 

  142. Mech. Dev. Shook 120 11 1351 2003 10.1016/j.mod.2003.06.005 Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development 

  143. Development Simian 128 3117 2001 10.1242/dev.128.16.3117 The interplay of matrix metalloproteinases. In: Morphogens and Growth Factors is Necessary for Branching of Mammary Epithelial Cells 

  144. Drug Discov. Today Skardal 21 9 1399 2016 10.1016/j.drudis.2016.07.003 Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling 

  145. Nat. Nanotechnol. Souza 5 291 2010 10.1038/nnano.2010.23 Three-dimensional tissue culture based on magnetic cell levitation 

  146. Nature Spence 470 7332 105 2011 10.1038/nature09691 Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro 

  147. Spencer 508 269 2014 Direct Measurement of Local Oxygen Concentration in the Bone Marrow of Live Animals 

  148. Cell Stange 155 2 357 2013 10.1016/j.cell.2013.09.008 Differentiated troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium 

  149. Stevens 106 16568 2009 Physiological Function and Transplantation of Scaffold-Free and Vascularized Human Cardiac Muscle Tissue 

  150. Emerg. Microbes. Infect. Strange 7 1 82 2018 10.1038/s41426-018-0080-7 Human testicular organoid system as a novel tool to study Zika virus pathogenesis 

  151. J. Biotechnol. Sun 122 3 372 2006 10.1016/j.jbiotec.2005.12.021 Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents 

  152. J. Natl. Cancer Inst. Sutherland 46 113 1971 Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas 

  153. Cell Stem Cell Taguchi 14 1 53 2014 10.1016/j.stem.2013.11.010 Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells 

  154. Development Takasato 142 11 1937 2015 10.1242/dev.104802 The origin of the mammalian kidney: implications for recreating the kidney in vitro 

  155. Nat. Cell Biol. Takasato 16 1 118 2014 10.1038/ncb2894 Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney 

  156. Nat. Protoc. Takasato 11 9 1681 2016 10.1038/nprot.2016.098 Generation of kidney organoids from human pluripotent stem cells 

  157. Nature Takebe 499 481 2013 10.1038/nature12271 Vascularized and functional human liver from an iPSC-derived organ bud transplant 

  158. Nature Takebe 499 481 2013 10.1038/nature12271 Vascularized and functional human liver from an iPSC-derived organ bud transplant 

  159. Dev. Cell Thorne 44 5 624 2018 10.1016/j.devcel.2018.01.024 Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization 

  160. Biochem. Biophys. Res. Commun. Toda 294 4 906 2002 10.1016/S0006-291X(02)00561-2 A new organotypic culture of thyroid tissue maintains three-dimensional follicles with C cells for a long term 

  161. Tissue Eng. C. Tseng 19 9 665 2013 10.1089/ten.tec.2012.0157 Assembly of a three-dimensional multitype bronchiole coculture model using magnetic levitation 

  162. J. Stem Cell Res. Ther. Tucker 3 5 161 2014 Duplication of TBK1 stimulates autophagy in iPSC-derived retinal Cells from a patient with normal tension glaucoma 

  163. Science Tuveson 364 6444 952 2019 10.1126/science.aaw6985 Cancer modeling meets human organoid technology 

  164. Toxicol. Sci. Upadhyay 164 1 21 2018 10.1093/toxsci/kfy053 Air-liquid interface: relevant in vitro models for investigating air pollutant-induced pulmonary toxicity 

  165. Curr Protoc Toxicol Usui 75 22 26 21 2018 10.1002/cptx.40 Preparation of Human primary colon tissue-derived organoid using air liquid interface culture 

  166. Cell van de Wetering 161 4 933 2015 10.1016/j.cell.2015.03.053 Prospective derivation of a living organoid biobank of colorectal cancer patients 

  167. Cell van de Wetering 161 4 933 2015 10.1016/j.cell.2015.03.053 Prospective derivation of a living organoid biobank of colorectal cancer patients 

  168. Stem Cell Res. van der Hee 28 165 2018 10.1016/j.scr.2018.02.013 Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids 

  169. PLoS Med. van der Worp 7 3 2010 10.1371/journal.pmed.1000245 Can Animal Models of Disease Reliably Inform Human Studies? 

  170. Elsevier Inc. Vaughan 74 141 2006 A Three-Dimensional Model of Differentiation of Immortalized Human Bronchial Epithelial Cells 

  171. Sci. (N. Y. N.Y.) Vlachogiannis 359 6378 920 2018 10.1126/science.aao2774 Patient-derived organoids model treatment response of metastatic gastrointestinal cancers 

  172. Nat. Methods Vogt 16 2 144 2019 10.1038/s41592-019-0319-9 Organoids that model the fetal placenta 

  173. Stem Cell Rep. Volkner 6 4 525 2016 10.1016/j.stemcr.2016.03.001 Retinal organoids from pluripotent stem cells efficiently recapitulate retinogenesis 

  174. Mol. Autism Wang 8 1 11 2017 10.1186/s13229-017-0124-1 CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells 

  175. Lab Chip Wang 18 6 851 2018 10.1039/C7LC01084B Human brain organoid-on-a-chip to model prenatal nicotine exposure 

  176. Nat. Med. Watson 20 11 1310 2014 10.1038/nm.3737 An in vivo model of human small intestine using pluripotent stem cells 

  177. J. Cell Biol. Weaver 137 1 231 1997 10.1083/jcb.137.1.231 Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies 

  178. Cell Chem. Biol. Weeber 24 9 1092 2017 10.1016/j.chembiol.2017.06.012 Tumor organoids as a pre-clinical cancer model for drug discovery 

  179. J. Vis. Exp. Xue 75 e50210 2013 In vitro organoid culture of primary mouse colon tumors 

  180. Yan 23 6 882 2018 A comprehensive human gastric cancer organoid biobank captures tumor subtype heterogeneity and enables therapeutic screening. cell stem cell 

  181. Antivir. Res. Yin 123 120 2015 10.1016/j.antiviral.2015.09.010 Modeling rotavirus infection and antiviral therapy using primary intestinal organoids 

  182. Cell Stem Cell Yin 18 1 25 2016 10.1016/j.stem.2015.12.005 Engineering stem cell organoids 

  183. Drug Discov. Today Yu 24 6 1248 2019 10.1016/j.drudis.2019.03.025 Microfluidic bioprinting for organ-on-a-chip models 

  184. Micromachines (Basel) Yu 10 3 2019 Engineering microfluidic organoid-on-a-chip platforms 

  185. Biomaterials Zhang 110 45 2016 10.1016/j.biomaterials.2016.09.003 Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip 

  186. J. Med. Chem. Zomer-van Ommen 59 14 6968 2016 10.1021/acs.jmedchem.6b00770 Functional characterization of cholera toxin inhibitors using human intestinal organoids 

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로