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Natural Furanocoumarin as Potential Oral Absorption Enhancer

Key engineering materials, v.819, 2019년, pp.63 - 69  

Maw, May Phyu Thein (Silpakorn University) ,  Phattanawasin, Panadda (Silpakorn University) ,  Sotanaphun, Uthai (Silpakorn University) ,  Piyapolrungroj, Nusara (Silpakorn University)

Abstract AI-Helper 아이콘AI-Helper

Bioavailability of orally administered drugs can be influenced by many factors. Poor drug absorption across the intestinal membrane is one of the factors that contribute to low bioavailability of drugs. It has been suggested that the metabolism/active efflux in the small intestine is involved in the...

참고문헌 (20)

  1. A.S, Darwich, S. Neuhoff, M. Jamei, A. Rostami-Hodjegan, Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the Advanced Dissolution, Absorption, Metabolism (ADAM), model, Curr. Drug Metab. 11 (2010) 716-729. 10.2174/138920010794328913 

  2. F. Thiebaut , T. Tsuruo, H. Hamada, M.M. Gottesman, I. Pastan, M.C. Willingham, Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues, Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 7735-7738. 10.1073/pnas.84.21.7735 

  3. H. Suzuki, Y. Sugiyama, Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine, Eur. J. Pharm. Sci. 12 (2000) 3-12. 10.1016/s0928-0987(00)00178-0 

  4. P-A. Billat, R. Emilie, S. Faure, F. Lagarce, Models for drug absorption from the small intestine: where are we and where are we going?, Drug Discov. Today 22 (2017) 761-775. 10.1016/j.drudis.2017.01.007 

  5. Y. Zhang, L.Z. Benet, The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein, Clin. Pharmacokinet. 40 (2001) 159-168. 10.2165/00003088-200140030-00002 

  6. L.Z. Benet, C.L. Cummins, C.Y. Wu, Unmasking the dynamic interplay between efflux transporters and metabolic enzymes, Int. J. Pharm. 277 (2004) 3-9. 10.1016/j.ijpharm.2002.12.002 

  7. G. Randhawa, J. S. Kullar, Rajkumar, Bioenhancers from mother nature and their applicability in modern medicine, Int. J. Appl. Basic Med. Res. 1 (2011) 5-10. 10.4103/2229-516x.81972 

  8. Ajazuddin, A. Alexander A, A. Qureshi A, L. Kumari, P. Vaishnav, M. Sharma, S. Saraf, S. Saraf, Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients, Fitoterapia. 97 (2014) 1-14. 10.1016/j.fitote.2014.05.005 

  9. B. Peterson, M. Weyers, J.H. Steenekamp, J.D. Steyn, C. Gouws, J.H Hamman, Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism, Pharmaceutics. 16 (2019) 1-46. 10.3390/pharmaceutics11010033 

  10. E. Valenciennes, J. Smadja, J.Y. Conan, Screening for biological activity and chemical composition of Euodia borbonica var. borbonica (Rutaceae), a medicinal plant in Reunion Island, J. Ethnopharmacol. 64 (1999) 283-288. 10.1016/s0378-8741(98)00137-8 

  11. G. Lehr, T.L. Barry, J. Franolic, P. Glenn, P. Scheiner, LC determination of impurities in methoxsalen drug substance: isolation and identification of isopimpinellin as a major impurity by atmospheric pressure chemical ionization LC/MS and NMR, J. Pharm. Biomed. Anal. 33 (2003) 627-637. 10.1016/s0731-7085(03)00353-4 

  12. A. Murakami, G. Gao, K. Kim, M. Omura, M. Yano, C. Ito, H. Furukawa, S. Jiwajinda, K. Koshimizu, H. Ohigashi H, Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells, J. Agric. Food Chem.47 (1999) 333-339. 10.1021/jf980523e 

  13. D. L. Dreyer, P.F. Huey, Coumarins of Citrus macroptera, Phytochemistry. 12 (1973) 3011-3013. 10.1016/0031-9422(73)80536-9 

  14. Y. Tanigawara, N. Okamura, M. Hirai, M. Yasuhara, K. Ueda, N. Kioka, T. Komano, R. Hori, Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1), J. Pharmacol. Exp. Ther. 263 (1992) 840-845. 

  15. 10.1016/S0021-9258(18)35757-0 K. Ueda, N. Okamura, M. Hirai, Y. Tanigawara, T. Saeki, N. Kioka, T. Komano, R. Hori, Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J. Biol. Chem. 267 (1992) 24248-24252. 

  16. 10.1023/A:1025096930604 M.D. Troutman, D.R. Thakker, Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells, Pharm. Res. 20 (2003) 1192-1199. 

  17. O. Legrand, G. Simonin, J.Y. Perrot, R. Zittoun, J.P. Marie, Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients. Blood. 15 (1998) 4480-4488. 

  18. D.J. Greenblatt, Y. Zhao, K. Venkatakrishnan, S.X. Duan, J.S. Harmatz, S.J. Parent, M.H. Court, L.L. von Moltke, Mechanism of cytochrome P450-3A inhibition by ketoconazole, J. Pharm. Pharmacol. 63 (2011) 214-221. 10.1111/j.2042-7158.2010.01202.x 

  19. M. Li, I.A. de Graaf, E. van de Steeg, M.H. de Jager, G.M. Groothuis, The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo, Toxicol. in Vitro 40 (2017) 26-33. 10.1016/j.tiv.2016.12.002 

  20. D.V. Tatiraju, V.B. Bagade, P.J. Karambelkar, V.M. Jadhav, V. Kadam, Natural bioenhancers: an overview, J. Pharmacogn. Phytochem. 2 (2013) 55-60. 

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