[논문]Bestrophin1‐mediated tonic GABA release from reactive astrocytes prevents the development of seizure‐prone network in kainate‐injected hippocampi

Pandit, Sudip; Neupane, Chiranjivi; Woo, Junsung; Sharma, Ramesh; Nam, Min‐; Ho; Lee, Gyu‐; Seung; Yi, Min‐; Hee; Shin, Nara; Kim, Dong Woon; Cho, Hyunsill; Jeon, Byeong Hwa; Kim, Hyun‐; Woo; Lee, C. Justin; Park, Jin Bong

doi:10.1002/glia.23762

[해외논문] Bestrophin1‐mediated tonic GABA release from reactive astrocytes prevents the development of seizure‐prone network in kainate‐injected hippocampi

GLIA, v.68 no.5, 2020년, pp.1065 - 1080

Pandit, Sudip (Department of Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon, Republic of Korea) , Neupane, Chiranjivi (Department of Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon, Republic of Korea) , Woo, Junsung (Center for Glia‐) , Sharma, Ramesh (Neuron Interaction and Neuroscience, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea) , Nam, Min‐Ho (Department of Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon, Republic of Korea) , Lee, Gyu‐Seung (Center for Glia‐) , Yi, Min‐Hee (Neuron Interaction and Neuroscience, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea) , Shin, Nara (Department of Physiology, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon, R) , Kim, Dong Woon , Cho, Hyunsill , Jeon, Byeong Hwa , Kim, Hyun‐Woo , Lee, C. Justin , Park, Jin Bong

Abstract ▼ AI-Helper

AbstractTonic extrasynaptic GABAA receptor (GABAAR) activation is under the tight control of tonic GABA release from astrocytes to maintain the brain's excitation/inhibition (E/I) balance; any slight E/I balance disturbance can cause serious pathological conditions including epileptic seizures. However, the pathophysiological role of tonic GABA release from astrocytes has not been tested in epileptic seizures. Here, we report that pharmacological or genetic intervention of the GABA‐permeable Bestrophin‐1 (Best1) channel prevented the generation of tonic GABA inhibition, disinhibiting CA1 pyramidal neuronal firing and augmenting seizure susceptibility in kainic acid (KA)‐induced epileptic mice. Astrocyte‐specific Best1 over‐expression in KA‐injected Best1 knockout mice fully restored the generation of tonic GABA inhibition and effectively suppressed seizure susceptibility. We demonstrate for the first time that tonic GABA from reactive astrocytes strongly contributes to the compensatory shift of E/I balance in epileptic hippocampi, serving as a good therapeutic target against altered E/I balance in epileptic seizures.Main pointsThe GABA‐permeable Best1 channel is solely responsible for tonic astrocytic GABA release in epileptic hippocampi.Tonic GABA release from reactive astrocytes strongly contributes to the compensatory shift of E/I balance in epileptic hippocampi.

Keyword

참고문헌 (47)

Ben‐Ari , Y. ( 2002 ). Excitatory actions of GABA during development: The nature of the nurture . Nature Reviews. Neuroscience , 3 ( 9 ), 728 – 739 . https://doi.org/10.1038/nrn920

상세보기
Bonansco , C. , & Fuenzalida , M. ( 2016 ). Plasticity of hippocampal excitatory‐inhibitory balance: Missing the synaptic control in the epileptic brain . Neural Plasticity , 2016 , 8607038. doi: https://doi.org/10.1155/2016/8607038, 1 , 13

상세보기
Borden , L. A. , Murali Dhar , T. G. , Smith , K. E. , Weinshank , R. L. , Branchek , T. A. , & Gluchowski , C. ( 1994 ). Tiagabine, SK&F 89976‐a, CI‐966, and NNC‐711 are selective for the cloned GABA transporter GAT‐1 . European Journal of Pharmacology , 269 ( 2 ), 219 – 224 .

상세보기
Chun , H. , & Lee , C. J. ( 2018 ). Reactive astrocytes in Alzheimer's disease: A double‐edged sword . Neuroscience Research , 126 , 44 – 52 . https://doi.org/10.1016/j.neures.2017.11.012

상세보기
Cope , D. W. , Di Giovanni , G. , Fyson , S. J. , Orban , G. , Errington , A. C. , Lorincz , M. L. , … Crunelli , V. ( 2009 ). Enhanced tonic GABAA inhibition in typical absence epilepsy . Nature Medicine , 15 ( 12 ), 1392 – 1398 . https://doi.org/10.1038/nm.2058

상세보기
Cossart , R. , Dinocourt , C. , Hirsch , J. C. , Merchan‐Perez , A. , De Felipe , J. , Ben‐Ari , Y. , … Bernard , C. ( 2001 ). Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy . Nature Neuroscience , 4 ( 1 ), 52 – 62 . https://doi.org/10.1038/82900

상세보기
Czapinski , P. , Blaszczyk , B. , & Czuczwar , S. J. ( 2005 ). Mechanisms of action of antiepileptic drugs . Current Topics in Medicinal Chemistry , 5 ( 1 ), 3 – 14 .

상세보기
Diaz , M. R. , Wadleigh , A. , Hughes , B. A. , Woodward , J. J. , & Valenzuela , C. F. ( 2011 ). Bestrophin1 channels are insensitive to ethanol and do not mediate tonic GABAergic currents in cerebellar granule cells . Frontiers in Neuroscience , 5 , 148 . https://doi.org/10.3389/fnins.2011.00148

상세보기
Farrant , M. , & Nusser , Z. ( 2005 ). Variations on an inhibitory theme: Phasic and tonic activation of GABA(a) receptors . Nature Reviews. Neuroscience , 6 ( 3 ), 215 – 229 . https://doi.org/10.1038/nrn1625

상세보기
Fritschy , J. M. ( 2008 ). Epilepsy, E/I balance and GABA(a) receptor plasticity . Frontiers in Molecular Neuroscience , 1 , 5 . https://doi.org/10.3389/neuro.02.005.2008

상세보기
Glykys , J. , & Mody , I. ( 2007 ). The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus . The Journal of Physiology , 582 ( Pt 3 ), 1163 – 1178 . https://doi.org/10.1113/jphysiol.2007.134460

상세보기
Jo , J. Y. , Jeong , J. A. , Pandit , S. , Stern , J. E. , Lee , S. K. , Ryu , P. D. , … Park , J. B. ( 2011 ). Neurosteroid modulation of benzodiazepine‐sensitive GABAA tonic inhibition in supraoptic magnocellular neurons . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 300 ( 6 ), R1578 – R1587 . https://doi.org/10.1152/ajpregu.00627.2010

상세보기
Jo , S. , Yarishkin , O. , Hwang , Y. J. , Chun , Y. E. , Park , M. , Woo , D. H. , … Lee , C. J. ( 2014 ). GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease . Nature Medicine , 20 ( 8 ), 886 – 896 . https://doi.org/10.1038/nm.3639

상세보기
Kim , Y. S. , Woo , J. , Lee , C. J. , & Yoon , B. E. ( 2017 ). Decreased glial GABA and tonic inhibition in cerebellum of mouse model for attention‐deficit/hyperactivity disorder (ADHD) . Experimental Neurobiology , 26 ( 4 ), 206 – 212 . https://doi.org/10.5607/en.2017.26.4.206

상세보기
Kirmse , K. , Witte , O. W. , & Holthoff , K. ( 2011 ). GABAergic depolarization during early cortical development and implications for anticonvulsive therapy in neonates . Epilepsia , 52 ( 9 ), 1532 – 1543 . https://doi.org/10.1111/j.1528-1167.2011.03128.x

상세보기
Kobayashi , M. , & Buckmaster , P. S. ( 2003 ). Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy . The Journal of Neuroscience , 23 ( 6 ), 2440 – 2452 .

상세보기
Lee , S. , Yoon , B. E. , Berglund , K. , Oh , S. J. , Park , H. , Shin , H. S. , … Lee , C. J. ( 2010 ). Channel‐mediated tonic GABA release from glia . Science , 330 ( 6005 ), 790 – 796 . https://doi.org/10.1126/science.1184334

상세보기
Lee , V. , & Maguire , J. ( 2014 ). The impact of tonic GABAA receptor‐mediated inhibition on neuronal excitability varies across brain region and cell type . Frontiers in Neural Circuits , 8 , 3 . https://doi.org/10.3389/fncir.2014.00003

상세보기
Leroy , C. , Poisbeau , P. , Keller , A. F. , & Nehlig , A. ( 2004 ). Pharmacological plasticity of GABA(a) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy . The Journal of Physiology , 557 ( Pt 2 ), 473 – 487 . https://doi.org/10.1113/jphysiol.2003.059246

상세보기
McLin , J. P. , & Steward , O. ( 2006 ). Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains . The European Journal of Neuroscience , 24 ( 8 ), 2191 – 2202 . https://doi.org/10.1111/j.1460-9568.2006.05111.x

상세보기
Mody , I. , & Pearce , R. A. ( 2004 ). Diversity of inhibitory neurotransmission through GABA(a) receptors . Trends in Neurosciences , 27 ( 9 ), 569 – 575 . https://doi.org/10.1016/j.tins.2004.07.002

상세보기
Mortensen , M. , Patel , B. , & Smart , T. G. ( 2011 ). GABA potency at GABA(a) receptors found in synaptic and Extrasynaptic zones . Frontiers in Cellular Neuroscience , 6 , 1 . https://doi.org/10.3389/fncel.2012.00001

상세보기
Naylor , D. E. , Liu , H. , & Wasterlain , C. G. ( 2005 ). Trafficking of GABA(a) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus . The Journal of Neuroscience , 25 ( 34 ), 7724 – 7733 . https://doi.org/10.1523/JNEUROSCI.4944-04.2005

상세보기
Oh , S. J. , & Lee , C. J. ( 2017 ). Distribution and function of the Bestrophin‐1 (Best1) channel in the brain . Experimental Neurobiology , 26 ( 3 ), 113 – 121 . https://doi.org/10.5607/en.2017.26.3.113

상세보기
Pandit , S. , Jeong , J. A. , Jo , J. Y. , Cho , H. S. , Kim , D. W. , Kim , J. M. , … Park , J. B. ( 2013 ). Dual mechanisms diminishing tonic GABAA inhibition of dentate gyrus granule cells in Noda epileptic rats . Journal of Neurophysiology , 110 ( 1 ), 95 – 102 . https://doi.org/10.1152/jn.00727.2012

상세보기
Park , J. B. , Skalska , S. , & Stern , J. E. ( 2006 ). Characterization of a novel tonic gamma‐aminobutyric acidA receptor‐mediated inhibition in magnocellular neurosecretory neurons and its modulation by glia . Endocrinology , 147 ( 8 ), 3746 – 3760 . https://doi.org/10.1210/en.2006-0218

상세보기
Racine , R. J. ( 1972 ). Modification of seizure activity by electrical stimulation. II. Motor seizure . Electroencephalography and Clinical Neurophysiology , 32 ( 3 ), 281 – 294 . https://doi.org/10.1016/0013-4694(72)90177-0

상세보기
Rajasekaran , K. , Joshi , S. , Sun , C. , Mtchedlishvilli , Z. , & Kapur , J. ( 2010 ). Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals . Neurobiology of Disease , 40 ( 2 ), 490 – 501 . https://doi.org/10.1016/j.nbd.2010.07.016

상세보기
Santhakumar , V. , Hanchar , H. J. , Wallner , M. , Olsen , R. W. , & Otis , T. S. ( 2006 ). Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene . The Journal of Neuroscience , 26 ( 12 ), 3357 – 3364 . https://doi.org/10.1523/JNEUROSCI.4799-05.2006

상세보기
Schauwecker , P. E. , & Steward , O. ( 1997 ). Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches . Proceedings of the National Academy of Sciences of the United States of America , 94 ( 8 ), 4103 – 4108 .

상세보기
Scimemi , A. , Andersson , A. , Heeroma , J. H. , Strandberg , J. , Rydenhag , B. , McEvoy , A. W. , … Walker , M. C. ( 2006 ). Tonic GABA(a) receptor‐mediated currents in human brain . The European Journal of Neuroscience , 24 ( 4 ), 1157 – 1160 . https://doi.org/10.1111/j.1460-9568.2006.04989.x

상세보기
Scimemi , A. , Semyanov , A. , Sperk , G. , Kullmann , D. M. , & Walker , M. C. ( 2005 ). Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus . The Journal of Neuroscience , 25 ( 43 ), 10016 – 10024 . https://doi.org/10.1523/JNEUROSCI.2520-05.2005

상세보기
Semyanov , A. , Walker , M. C. , Kullmann , D. M. , & Silver , R. A. ( 2004 ). Tonically active GABA a receptors: Modulating gain and maintaining the tone . Trends in Neurosciences , 27 ( 5 ), 262 – 269 . https://doi.org/10.1016/j.tins.2004.03.005

상세보기
Sloviter , R. S. ( 1992 ). Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate‐treated rats . Neuroscience Letters , 137 ( 1 ), 91 – 96 . https://doi.org/10.1016/0304-3940(92)90306-r

상세보기
Sloviter , R. S. , Zappone , C. A. , Harvey , B. D. , & Frotscher , M. ( 2006 ). Kainic acid‐induced recurrent mossy fiber innervation of dentate gyrus inhibitory interneurons: Possible anatomical substrate of granule cell hyper‐inhibition in chronically epileptic rats . The Journal of Comparative Neurology , 494 ( 6 ), 944 – 960 . https://doi.org/10.1002/cne.20850

상세보기
Sofroniew , M. V. ( 2015 ). Astrocyte barriers to neurotoxic inflammation . Nature Reviews. Neuroscience , 16 ( 5 ), 249 – 263 . https://doi.org/10.1038/nrn3898

상세보기
Song , I. , Savtchenko , L. , & Semyanov , A. ( 2011 ). Tonic excitation or inhibition is set by GABA(a) conductance in hippocampal interneurons . Nature Communications , 2 , 376 . https://doi.org/10.1038/ncomms1377

상세보기
Sperk , G. , Schwarzer , C. , Heilman , J. , Furtinger , S. , Reimer , R. J. , Edwards , R. H. , & Nelson , N. ( 2003 ). Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures . Hippocampus , 13 ( 7 ), 806 – 815 . https://doi.org/10.1002/hipo.10133

상세보기
Woo , J. , Min , J. O. , Kang , D. S. , Kim , Y. S. , Jung , G. H. , Park , H. J. , … Yoon , B. E. ( 2018 ). Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum . Proceedings of the National Academy of Sciences of the United States of America , 115 ( 19 ), 5004 – 5009 . https://doi.org/10.1073/pnas.1721187115

상세보기
Wu , Y. , Wang , W. , Diez‐Sampedro , A. , & Richerson , G. B. ( 2007 ). Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT‐1 . Neuron , 56 ( 5 ), 851 – 865 . https://doi.org/10.1016/j.neuron.2007.10.021

상세보기
Wu , Z. , Guo , Z. , Gearing , M. , & Chen , G. ( 2014 ). Tonic inhibition in dentate gyrus impairs long‐term potentiation and memory in an Alzheimer's [corrected] disease model . Nature Communications , 5 , 4159 . https://doi.org/10.1038/ncomms5159

상세보기
Yarishkin , O. , Lee , J. , Jo , S. , Hwang , E. M. , & Lee , C. J. ( 2015 ). Disinhibitory action of Astrocytic GABA at the Perforant path to dentate Gyrus granule neuron synapse reverses to inhibitory in Alzheimer's disease model . Experimental Neurobiology , 24 ( 3 ), 211 – 218 . https://doi.org/10.5607/en.2015.24.3.211

상세보기
Yoon , B. E. , Jo , S. , Woo , J. , Lee , J. H. , Kim , T. , Kim , D. , & Lee , C. J. ( 2011 ). The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum . Molecular Brain , 4 , 42 . https://doi.org/10.1186/1756-6606-4-42

상세보기
Yoon , B. E. , Woo , J. , Chun , Y. E. , Chun , H. , Jo , S. , Bae , J. Y. , … Lee , C. J. ( 2014 ). Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition . The Journal of Physiology , 592 ( 22 ), 4951 – 4968 . https://doi.org/10.1113/jphysiol.2014.278754

상세보기
Zappone , C. A. , & Sloviter , R. S. ( 2004 ). Translamellar disinhibition in the rat hippocampal dentate gyrus after seizure‐induced degeneration of vulnerable hilar neurons . The Journal of Neuroscience , 24 ( 4 ), 853 – 864 . https://doi.org/10.1523/JNEUROSCI.1619-03.2004

상세보기
Zhan , R. Z. , & Nadler , J. V. ( 2009 ). Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine‐induced status epilepticus . Journal of Neurophysiology , 102 ( 2 ), 670 – 681 . https://doi.org/10.1152/jn.00147.2009

상세보기
Zhang , N. , Wei , W. , Mody , I. , & Houser , C. R. ( 2007 ). Altered localization of GABA(a) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy . The Journal of Neuroscience , 27 ( 28 ), 7520 – 7531 . https://doi.org/10.1523/JNEUROSCI.1555-07.2007

상세보기

LOADING...

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증