$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Repressive Effect of Sp1 on the C/EBPα Gene Promoter: Role in Adipocyte Differentiation 원문보기

Molecular and cellular biology, v.19 no.7, 1999년, pp.4855 - 4865  

Tang, Qi-Qun (Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205) ,  Jiang, Man-Shiow (Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205) ,  Lane, M. Daniel (Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205)

Abstract AI-Helper 아이콘AI-Helper

ABSTRACTExpression of C/EBPα is required for differentiation of 3T3-L1 preadipocytes into adipocytes. Previous investigations indicated that transcription of the C/EBPα gene is sequentially activated during differentiation, initially by C/EBPβ and C/EBPδ and later by C/EBP&alp...

참고문헌 (35)

  1. Bernlohr, D A, Bolanowski, M A, Kelly Jr., T J, Lane, M D. Evidence for an increase in transcription of specific mRNAs during differentiation of 3T3-L1 preadipocytes.. The Journal of biological chemistry, vol.260, no.9, 5563-5567.

  2. Cao, Z, Umek, R M, McKnight, S L. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.. Genes & development, vol.5, no.9, 1538-1552.

  3. Cheneval, D, Christy, R J, Geiman, D, Cornelius, P, Lane, M D. Cell-free transcription directed by the 422 adipose P2 gene promoter: activation by the CCAAT/enhancer binding protein.. Proceedings of the National Academy of Sciences of the United States of America, vol.88, no.19, 8465-8469.

  4. Christy, R J, Kaestner, K H, Geiman, D E, Lane, M D. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes.. Proceedings of the National Academy of Sciences of the United States of America, vol.88, no.6, 2593-2597.

  5. Christy, R J, Yang, V W, Ntambi, J M, Geiman, D E, Landschulz, W H, Friedman, A D, Nakabeppu, Y, Kelly, T J, Lane, M D. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.. Genes & development, vol.3, no.9, 1323-1335.

  6. Cooke, David W., Lane, M. Daniel. A Sequence Element in the GLUT4 Gene That Mediates Repression by Insulin. The Journal of biological chemistry, vol.273, no.11, 6210-6217.

  7. Cornelius, P., and M. D. Lane. Unpublished results. 

  8. Cornelius, P, MacDougald, O A, Lane, M D. Regulation of Adipocyte Development. Annual review of nutrition, vol.14, 99-129.

  9. Han, Innoc, Kudlow, Jeffrey E.. Reduced O Glycosylation of Sp1 Is Associated with Increased Proteasome Susceptibility. Molecular and cellular biology, vol.17, no.5, 2550-2558.

  10. Mol. Cell. Biol. Herrera R. 5331 9 1989 

  11. Hwang, Cheng-Shine, Loftus, Thomas M., Mandrup, Susanne, Lane, M. Daniel. ADIPOCYTE DIFFERENTIATION AND LEPTIN EXPRESSION. Annual review of cell and developmental biology, vol.13, 231-259.

  12. Hwang, C S, Mandrup, S, MacDougald, O A, Geiman, D E, Lane, M D. Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha.. Proceedings of the National Academy of Sciences of the United States of America, vol.93, no.2, 873-877.

  13. Jackson, S.P., MacDonald, J.J., Lees-Miller, S., Tjian, R.. GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell, vol.63, no.1, 155-165.

  14. Janicot, M., and M. D. Lane. Unpublished results. 

  15. Jiang, Man-Shiow, Tang, Qi-Qun, McLenithan, John, Geiman, Deb, Shillinglaw, Wendy, Henzel, William J., Lane, M. Daniel. Derepression of the C/EBPα gene during adipogenesis: Identification of AP-2α as a repressor. Proceedings of the National Academy of Sciences of the United States of America, vol.95, no.7, 3467-3471.

  16. Kaestner, K H, Christy, R J, Lane, M D. Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein.. Proceedings of the National Academy of Sciences of the United States of America, vol.87, no.1, 251-255.

  17. Lavery, D J, Schibler, U. Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.. Genes & development, vol.7, no.10, 1871-1884.

  18. Lee, Ying-Hue, Williams, Simon C., Baer, Mark, Sterneck, Esta, Gonzalez, Frank J., Johnson, Peter F.. The Ability of C/EBPβ but Not C/EBPα To Synergize with an Sp1 Protein Is Specified by the Leucine Zipper and Activation Domain. Molecular and cellular biology, vol.17, no.4, 2038-2047.

  19. Nucleic Acids Res. Legraverend C. 1735 21 1993 10.1093/nar/21.8.1735 

  20. Lin, F T, Lane, M D. Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes.. Genes & development, vol.6, no.4, 533-544.

  21. Lin, F T, Lane, M D. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program.. Proceedings of the National Academy of Sciences of the United States of America, vol.91, no.19, 8757-8761.

  22. Lin, F T, MacDougald, O A, Diehl, A M, Lane, M D. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.. Proceedings of the National Academy of Sciences of the United States of America, vol.90, no.20, 9606-9610.

  23. MacDougald, O.A., Cornelius, P., Lin, F.T., Chen, S.S., Lane, M.D.. Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue.. The Journal of biological chemistry, vol.269, no.29, 19041-19047.

  24. MacDougald, Ormond A., Cornelius, Peter, Liu, Raymond, Lane, M.Daniel. Insulin Regulates Transcription of the CCAAT/Enhancer Binding Protein (C/EBP) α , β , and δ Genes in Fully-differentiated 3T3-L1 Adipocytes. The Journal of biological chemistry, vol.270, no.2, 647-654.

  25. MacDougald, O A, Lane, M D. Transcriptional Regulation of Gene Expression During Adipocyte Differentiation. Annual review of biochemistry, vol.64, 345-373.

  26. Promega Technical Bulletin no. 137. Promega Corporation 1997 

  27. Samuelsson, L., Strömberg, K., Vikman, K., Bjursell, G., Enerbäck, S.. The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development.. The EMBO journal, vol.10, no.12, 3787-3793.

  28. J. Cyclic Nucleotide Res. Seamon K. B. 201 7 1981 

  29. Student, A.K., Hsu, R.Y., Lane, M.D.. Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes.. The Journal of biological chemistry, vol.255, no.10, 4745-4750.

  30. Tang, Qi-Qun, Jiang, Man-Shiow, Lane, M. Daniel. Repression of transcription mediated by dual elements in the CCAAT/enhancer binding protein α gene. Proceedings of the National Academy of Sciences of the United States of America, vol.94, no.25, 13571-13575.

  31. Umek, RM, Friedman, AD, McKnight, SL. CCAAT-enhancer binding protein: a component of a differentiation switch. Science, vol.251, no.4991, 288-292.

  32. Vasseur-Cognet, M, Lane, M D. CCAAT/enhancer binding protein alpha (C/EBP alpha) undifferentiated protein: a developmentally regulated nuclear protein that binds to the C/EBP alpha gene promoter.. Proceedings of the National Academy of Sciences of the United States of America, vol.90, no.15, 7312-7316.

  33. Wu, Zhidan, Bucher, Nancy L. R., Farmer, Stephen R.. Induction of Peroxisome Proliferator-Activated Receptor γ during the Conversion of 3T3 Fibroblasts into Adipocytes Is Mediated by C/EBPβ, C/EBPδ, and Glucocorticoids. Molecular and cellular biology, vol.16, no.8, 4128-4136.

  34. Wu, Z, Xie, Y, Bucher, N L, Farmer, S R. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis.. Genes & development, vol.9, no.19, 2350-2363.

  35. Yeh, W C, Cao, Z, Classon, M, McKnight, S L. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.. Genes & development, vol.9, no.2, 168-181.

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로