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[해외논문] Development and evaluation of TPGS/PVA-based nanosuspension for enhancing dissolution and oral bioavailability of ticagrelor

International journal of pharmaceutics, v.581, 2020년, pp.119287 -   

Na, Young-Guk (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University) ,  Pham, Thi Mai Anh (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University) ,  Byeon, Jin-Ju (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University) ,  Kim, Min-Ki (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University) ,  Han, Min-Gu (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University) ,  Baek, Jong-Suep (Department of Herbal Medicine Resource, Kangwon National University) ,  Lee, Hong-Ki (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University) ,  Cho, Cheong-Weon (College of Pharmacy and Institute of Drug Research and Development, Chungnam)

Abstract AI-Helper 아이콘AI-Helper

Abstract In this study, we developed ticagrelor-dispersed nanosuspension (TCG-NSP) to enhance the dissolution and oral bioavailability of ticagrelor (TCG) through a statistical design approach. TCG, a reversible P2Y12 receptor antagonist, is classified as a biopharmaceutics classification system (B...

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참고문헌 (47)

  1. Int. J. Nanomed. Ahmed 11 515 2016 10.2147/IJN.S98080 Preparation of finasteride capsules-loaded drug nanoparticles: formulation, optimization, in vitro, and pharmacokinetic evaluation 

  2. Clin. Pharmacokinet. Amilon 58 1295 2019 10.1007/s40262-019-00758-0 Population pharmacokinetics/pharmacodynamics of ticagrelor in children with sickle cell disease 

  3. AAPS PharmSciTech Bajaj 13 1331 2012 10.1208/s12249-012-9860-x Nanocrystallization by evaporative antisolvent technique for solubility and bioavailability enhancement of telmisartan 

  4. Drug Des. Devel. Ther. Bartos 13 4007 2019 10.2147/DDDT.S220876 Transformation of meloxicam containing nanosuspension into surfactant-free solid compositions to increase the product stability and drug bioavailability for rapid analgesia 

  5. Lancet Cannon 375 283 2010 10.1016/S0140-6736(09)62191-7 Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study 

  6. Mol. Pharm. Collnot 4 465 2007 10.1021/mp060121r Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity 

  7. Res. Pharm. Sci. Dizaj 10 95 2015 Nanosizing of drugs: effect on dissolution rate 

  8. Int. J. Pharm. Gajera 559 348 2019 10.1016/j.ijpharm.2019.01.054 Development of an amorphous nanosuspension by sonoprecipitation-formulation and process optimization using design of experiment methodology 

  9. J. Control. Release Ghadi 248 71 2017 10.1016/j.jconrel.2017.01.014 BCS class IV drugs: highly notorious candidates for formulation development 

  10. Pharmaceutics Gigliobianco 10 E134 2018 10.3390/pharmaceutics10030134 Nanocrystals of poorly soluble drugs: drug bioavailability and physicochemical stability 

  11. Eur. J. Pharm. Biopharm. Huang 130 108 2018 10.1016/j.ejpb.2018.06.022 Increased bioavailability of efonidipine hydrochloride nanosuspensions by the wet-milling method 

  12. Cardiovasc. Ther. Husted 27 259 2009 10.1111/j.1755-5922.2009.00096.x Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist 

  13. Drug Deliv. Jain 22 940 2015 10.3109/10717544.2014.885999 Optimization of artemether-loaded NLC for intranasal delivery using central composite design 

  14. Int. J. Pharm. Jog 564 426 2019 10.1016/j.ijpharm.2019.04.050 Comprehensive quality by design approach for stable nanocrystalline drug products 

  15. Asian J. Pharm. Sci. Junyaprasert 10 13 2015 10.1016/j.ajps.2014.08.005 Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs 

  16. Int. J. Pharm. Kim 555 11 2019 10.1016/j.ijpharm.2018.11.038 A novel composition of ticagrelor by solid dispersion technique for increasing solubility and intestinal permeability 

  17. Macromolecules Kozlov 36 6054 2003 10.1021/ma021681g Adsorption of poly(vinyl alcohol) onto hydrophobic substrates. A general approach for hydrophilizing and chemically activating surfaces 

  18. Langmuir Lee 26 18055 2010 10.1021/la1039128 Steric stabilization of thermally responsive N-isopropylacrylamide particles by poly (vinyl alcohol) 

  19. Pharmaceutics Li 8 E17 2016 10.3390/pharmaceutics8020017 Nanomilling of drugs for bioavailability enhancement: a holistic formulation-process perspective 

  20. Int. J. Mol. Sci. Liu 17 E1171 2016 10.3390/ijms17071171 Developments in methods for measuring the intestinal absorption of nanoparticle-bound drugs 

  21. RSC Adv. Lu 6 49052 2016 10.1039/C6RA08392G Enhanced dissolution and oral bioavailability of lurasidone hydrochloride nanosuspensions prepared by antisolvent precipitation-ultrasonication method 

  22. Nano Res. Lu 11 4985 2018 10.1007/s12274-018-2152-3 Strategies to improve micelle stability for drug delivery 

  23. Fundam. Clin. Pharmacol. Marsousi 30 577 2016 10.1111/fcp.12219 Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cells 

  24. J. Matta 9 1940 2003 Hydrogen-hydrogen bonding: a stabilizing interaction in molecules and crystals. Chem.: Eur 

  25. Carbohydr. Polym. Mishra 127 300 2015 10.1016/j.carbpol.2015.03.077 Formulation and process optimization of naproxen nanosuspensions stabilized by hydroxy propyl methyl cellulose 

  26. Mater. Sci. Eng. C Mater. Biol. Appl. Mishra 63 62 2016 10.1016/j.msec.2016.02.046 Enhanced bioavailability of cinnarizine nanosuspensions by particle size engineering: Optimization and physicochemical investigations 

  27. Pharmaceutics Mishra 10 E191 2018 10.3390/pharmaceutics10040191 Solid lipid nanoparticles: emerging colloidal nano drug delivery systems 

  28. J. Control. Release Mu 80 129 2002 10.1016/S0168-3659(02)00025-1 Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol®) 

  29. Mater. Sci. Eng. C Mater. Biol. Appl. Na 104 109980 2019 10.1016/j.msec.2019.109980 Statistical approach for solidifying ticagrelor loaded self-microemulsifying drug delivery system with enhanced dissolution and oral bioavailability 

  30. Int. J. Nanomed. Na 14 1193 2019 10.2147/IJN.S190426 Strategic approach to developing a self-microemulsifying drug delivery system to enhance antiplatelet activity and bioavailability of ticagrelor 

  31. J. Drug Deliv. Sci. Technol. Na 54 101319 2019 10.1016/j.jddst.2019.101319 Application of statistical design on the early development of sustained-release tablet containing ivy leaf extract 

  32. Biol. Rev. Camb. Philos. Soc. Nakagawa 82 591 2007 10.1111/j.1469-185X.2007.00027.x Effect size, confidence interval and statistical significance: a practical guide for biologists 

  33. Int. J. Nanomedicine Onoue 9 1025 2014 10.2147/IJN.S38378 Nanodrugs: pharmacokinetics and safety 

  34. Drug Deliv. Pardeshi 20 47 2013 10.3109/10717544.2012.752421 Novel surface modified solid lipid nanoparticles as intranasal carriers for ropinirole hydrochloride: application of factorial design approach 

  35. Drug Dev. Ind. Pharm. Patel 44 1942 2018 10.1080/03639045.2018.1503296 A quality-by-design study to develop nifedipine nanosuspension: examining the relative impact of formulation variables, wet media milling process parameters and excipient variability on drug product quality attributes 

  36. Int. J. Pharm. Shekhawat 567 118415 2019 10.1016/j.ijpharm.2019.06.006 Risk assessment and QbD based optimization of an eprosartan mesylate nanosuspension: in-vitro characterization, PAMPA and in-vivo assessment 

  37. Phytomedicine Singh 40 48 2018 10.1016/j.phymed.2017.12.021 Fabrication of surfactant-stabilized nanosuspension of naringenin to surpass its poor physiochemical properties and low oral bioavailability 

  38. J. Pharm. Invetig. Son 49 625 2018 10.1007/s40005-018-00417-9 Formulation and statistical analysis of an herbal medicine tablet containing morus alba leaf extracts 

  39. Pharmaceutics Son 11 E222 2019 10.3390/pharmaceutics11050222 Systemic design and evaluation of ticagrelor-loaded nanostructured lipid carriers for enhancing bioavailability and antiplatelet activity 

  40. Br. J. Pharmacol. Sugidachi 169 82 2013 10.1111/bph.12108 A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats 

  41. Clin. Pharmacokinet. Teng 54 1125 2015 10.1007/s40262-015-0290-2 Ticagrelor: pharmacokinetic, pharmacodynamic and pharmacogenetic profile: an update 

  42. Clin. Drug Investig. Teng 34 529 2014 10.1007/s40261-014-0205-2 Pharmacokinetic interaction study of ticagrelor and cyclosporine in healthy volunteers 

  43. Int. J. Pharm. Investig. Thadkala 4 131 2014 10.4103/2230-973X.138344 Preparation and characterization of amorphous ezetimibe nanosuspensions intended for enhancement of oral bioavailability 

  44. Pharmaceutics Tuomela 8 E16 2016 10.3390/pharmaceutics8020016 Stabilizing agents for drug nanocrystals: effect on bioavailability 

  45. Appl. Nanosic. Velmurugan 6 159 2016 10.1007/s13204-015-0434-6 Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology 

  46. Int. J. Pharm. Wang 566 67 2019 10.1016/j.ijpharm.2019.05.051 Development of daidzein nanosuspensions: preparation, characterization, in vitro evaluation, and pharmacokinetic analysis 

  47. Adv. Drug Deliv. Rev. Yun 65 822 2013 10.1016/j.addr.2012.10.007 Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery 

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