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[해외논문] Optimization of 3D hydrogel microenvironment for enhanced hepatic functionality of primary human hepatocytes

Biotechnology and bioengineering, v.117 no.6, 2020년, pp.1864 - 1876  

Lee, Ho‐Joon (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) ,  Ahn, Jiwon (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) ,  Jung, Cho‐Rock (Gene Therapy Unit, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) ,  Jeung, Yun‐Ji (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) ,  Cho, Hyun‐Soo (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) ,  Son, Myung Jin (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea ko<) ,  Chung, Kyung‐Sook

Abstract AI-Helper 아이콘AI-Helper

AbstractAlthough primary human hepatocytes (PHHs) are the gold standard in drug efficacy and metabolism studies, long‐term survival of PHHs and maintenance of their hepatic function are still challenging. In this study, we focused on the effect of the initial microenvironment on upregulation a...

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