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NTIS 바로가기Biotechnology and bioengineering, v.117 no.6, 2020년, pp.1864 - 1876
Lee, Ho‐Joon (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) , Ahn, Jiwon (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) , Jung, Cho‐Rock (Gene Therapy Unit, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) , Jeung, Yun‐Ji (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) , Cho, Hyun‐Soo (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) , Son, Myung Jin (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea ko<) , Chung, Kyung‐Sook
AbstractAlthough primary human hepatocytes (PHHs) are the gold standard in drug efficacy and metabolism studies, long‐term survival of PHHs and maintenance of their hepatic function are still challenging. In this study, we focused on the effect of the initial microenvironment on upregulation a...
Ahn , J. , Ahn , J. H. , Yoon , S. , Nam , Y. S. , Son , M. Y. , & Oh , J. H. ( 2019 ). Human three‐dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity . Journal of Biological Engineering , 13 , 22 . https://doi.org/10.1186/s13036‐019‐0148‐5
Ahn , J. , Lee , H. J. , Oh , S. J. , Kim , W. , Mun , S. J. , Lee , J. H. , … Chung , K. S. ( 2019 ). Developing scalable cultivation systems of hepatic spheroids for drug metabolism via genomic and functional analyses . Biotechnology and Bioengineering , 116 , 1496 – 1508 . https://doi.org/10.1002/bit.26954
Bell , C. C. , Dankers , A. C. A. , Lauschke , V. M. , Sison‐Young , R. , Jenkins , R. , Rowe , C. , … Ingelman‐Sundberg , M. ( 2018 ). Comparison of hepatic 2D sandwich cultures and 3D spheroids for long‐term toxicity applications: A multicenter study . Toxicological Sciences , 162 ( 2 ), 655 – 666 . https://doi.org/10.1093/toxsci/kfx289
Bell , C. C. , Hendriks , D. F. , Moro , S. M. , Ellis , E. , Walsh , J. , Renblom , A. , … Ingelman‐Sundberg , M. ( 2016 ). Characterization of primary human hepatocyte spheroids as a model system for drug‐induced liver injury, liver function and disease . Scientific Reports , 6 , 25187 . https://doi.org/10.1038/srep25187
Cao , L. , Zhang , Y. , Qian , M. , Wang , X. , Shuai , Q. , Gao , C. , … Yang , J. ( 2019 ). Construction of multicellular aggregate by E‐cadherin coated microparticles enhancing the hepatic specific differentiation of mesenchymal stem cells . Acta Biomaterialia , 95 , 382 – 394 . https://doi.org/10.1016/j.actbio.2019.01.030
Chen , C. S. , Mrksich , M. , Huang , S. , Whitesides , G. M. , & Ingber , D. E. ( 1997 ). Geometric control of cell life and death . Science , 276 ( 5317 ), 1425 – 1428 . https://doi.org/10.1126/science.276.5317.1425
Chen , K. F. , Tai , W. T. , Hsu , C. Y. , Huang , J. W. , Liu , C. Y. , Chen , P. J. , … Shiau , C. W. ( 2018 ). Corrigendum to “blockade of STAT3 activation by sorafenib derivatives through enhancing SHP‐1 phosphatase activity” [Eur. J. Med. Chem. 55 (2012) 220‐227] . European Journal of Medicinal Chemistry , 143 , 2015 . https://doi.org/10.1016/j.ejmech.2017.10.053
Cho , E. , Kutty , J. K. , Datar , K. , Lee , J. S. , Vyavahare , N. R. , & Webb , K. ( 2009 ). A novel synthetic route for the preparation of hydrolytically degradable synthetic hydrogels . Journal of Biomedical Materials Research Part A , 90 ( 4 ), 1073 – 1082 . https://doi.org/10.1002/jbm.a.32172
Chu , X. H. , Shi , X. L. , Feng , Z. Q. , Gu , Z. Z. , & Ding , Y. T. ( 2009 ). Chitosan nanofiber scaffold enhances hepatocyte adhesion and function . Biotechnology Letters , 31 ( 3 ), 347 – 352 . https://doi.org/10.1007/s10529‐008‐9892‐1
Dunn , J. C. , Tompkins , R. G. , & Yarmush , M. L. ( 1991 ). Long‐term in vitro function of adult hepatocytes in a collagen sandwich configuration . Biotechnology Progress , 7 ( 3 ), 237 – 245 . https://doi.org/10.1021/bp00009a007
Fung , J. , Lee , C. K. , Chan , M. , Seto , W. K. , Wong , D. K. , Lai , C. L. , & Yuen , M. F. ( 2013 ). Defining normal liver stiffness range in a normal healthy Chinese population without liver disease . PLoS One , 8 ( 12 ): e85067 . https://doi.org/10.1371/journal.pone.0085067
Gao , L. , McBeath , R. , & Chen , C. S. ( 2010 ). Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N‐cadherin . Stem Cells , 28 ( 3 ), 564 – 572 . https://doi.org/10.1002/stem.308
Georges , P. C. , Hui , J. J. , Gombos , Z. , McCormick , M. E. , Wang , A. Y. , Uemura , M. , … Wells , R. G. ( 2007 ). Increased stiffness of the rat liver precedes matrix deposition: Implications for fibrosis . American Journal of Physiology. Gastrointestinal and Liver Physiology , 293 ( 6 ), G1147 – G1154 . https://doi.org/10.1152/ajpgi.00032.2007
Gkretsi , V. , Bowen , W. C. , Yang , Y. , Wu , C. , & Michalopoulos , G. K. ( 2007 ). Integrin‐linked kinase is involved in matrix‐induced hepatocyte differentiation . Biochemical and Biophysical Research Communications , 353 ( 3 ), 638 – 643 . https://doi.org/10.1016/j.bbrc.2006.12.091
Godoy , P. , Hewitt , N. J. , Albrecht , U. , Andersen , M. E. , Ansari , N. , Bhattacharya , S. , … Hengstler , J. G. ( 2013 ). Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non‐parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME . Archives of Toxicology , 87 ( 8 ), 1315 – 1530 . https://doi.org/10.1007/s00204‐013‐1078-5
Gombotz , W. R. , Wang , G. H. , Horbett , T. A. , & Hoffman , A. S. ( 1991 ). Protein adsorption to poly(ethylene oxide) surfaces . Journal of Biomedical Materials Research , 25 ( 12 ), 1547 – 1562 . https://doi.org/10.1002/jbm.820251211
Hansen , L. K. , Mooney , D. J. , Vacanti , J. P. , & Ingber , D. E. ( 1994 ). Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth . Molecular Biology of the Cell , 5 ( 9 ), 967 – 975 . https://doi.org/10.1091/mbc.5.9.967
Hansen , L. K. , Wilhelm , J. , & Fassett , J. T. ( 2006 ). Regulation of hepatocyte cell cycle progression and differentiation by type I collagen structure . Current Topics in Developmental Biology , 72 , 205 – 236 . https://doi.org/10.1016/S0070-2153(05)72004‐4
Haussinger , D. , Reinehr , R. , & Schliess , F. ( 2006 ). The hepatocyte integrin system and cell volume sensing . Acta Physiologica (Oxford) , 187 ( 1–2 ), 249 – 255 . https://doi.org/10.1111/j.1748‐1716.2006.01542.x
Heidariyan , Z. , Ghanian , M. H. , Ashjari , M. , Farzaneh , Z. , Najarasl , M. , Rezaei Larijani , M. , … Baharvand , H. ( 2018 ). Efficient and cost‐effective generation of hepatocyte‐like cells through microparticle‐mediated delivery of growth factors in a 3D culture of human pluripotent stem cells . Biomaterials , 159 , 174 – 188 . https://doi.org/10.1016/j.biomaterials.2018.01.005
Hern , D. L. , & Hubbell , J. A. ( 1998 ). Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing . Journal of Biomedical Materials Research , 39 ( 2 ), 266 – 276 .
Higuchi , Y. , Kawai , K. , Kanaki , T. , Yamazaki , H. , Chesne , C. , Guguen‐Guillouzo , C. , & Suemizu , H. ( 2016 ). Functional polymer‐dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes . Hepatology Research , 46 ( 10 ), 1045 – 1057 . https://doi.org/10.1111/hepr.12644
Hoshiba , T. , Nagahara , H. , Cho , C. S. , Tagawa , Y. , & Akaike , T. ( 2007 ). Primary hepatocyte survival on non‐integrin‐recognizable matrices without the activation of Akt signaling . Biomaterials , 28 ( 6 ), 1093 – 1104 . https://doi.org/10.1016/j.biomaterials.2006.10.008
Jung , H. R. , Kang , H. M. , Ryu , J. W. , Kim , D. S. , Noh , K. H. , Kim , E. S. , … Jung , C. R. ( 2017 ). Cell spheroids with enhanced aggressiveness to mimic human liver cancer in vitro and in vivo . Scientific Reports , 7 ( 1 ): 10499 . https://doi.org/10.1038/s41598‐017‐10828‐7
Kikkawa , Y. , Takahashi , N. , Matsuda , Y. , Miwa , T. , Akizuki , T. , Kataoka , A. , & Nomizu , M. ( 2009 ). The influence of synthetic peptides derived from the laminin alpha1 chain on hepatocyte adhesion and gene expression . Biomaterials , 30 ( 36 ), 6888 – 6895 . https://doi.org/10.1016/j.biomaterials.2009.09.011
Kinney , M. A. , Hookway , T. A. , Wang , Y. , & McDevitt , T. C. ( 2014 ). Engineering three‐dimensional stem cell morphogenesis for the development of tissue models and scalable regenerative therapeutics . Annals of Biomedical Engineering , 42 ( 2 ), 352 – 367 . https://doi.org/10.1007/s10439‐013‐0953‐9
Klaas , M. , Kangur , T. , Viil , J. , Maemets‐Allas , K. , Minajeva , A. , Vadi , K. , … Jaks , V. ( 2016 ). The alterations in the extracellular matrix composition guide the repair of damaged liver tissue . Scientific Reports , 6 , 27398 . https://doi.org/10.1038/srep27398
Kutty , J. K. , Cho , E. , Soo Lee , J. , Vyavahare , N. R. , & Webb , K. ( 2007 ). The effect of hyaluronic acid incorporation on fibroblast spreading and proliferation within PEG‐diacrylate based semi‐interpenetrating networks . Biomaterials , 28 ( 33 ), 4928 – 4938 . https://doi.org/10.1016/j.biomaterials.2007.08.007
Lazaro‐Dieguez , F. , Cohen , D. , Fernandez , D. , Hodgson , L. , van Ijzendoorn , S. C. , & Musch , A. ( 2013 ). Par1b links lumen polarity with LGN‐NuMA positioning for distinct epithelial cell division phenotypes . The Journal of Cell Biology , 203 ( 2 ), 251 – 264 . https://doi.org/10.1083/jcb.201303013
Lee , H. J. , Sen , A. , Bae , S. , Lee , J. S. , & Webb , K. ( 2015 ). Poly(ethylene glycol) diacrylate/hyaluronic acid semi‐interpenetrating network compositions for 3‐D cell spreading and migration . Acta Biomaterialia , 14 , 43 – 52 . https://doi.org/10.1016/j.actbio.2014.12.007
Lee , H. J. , Son , M. J. , Ahn , J. , Oh , S. J. , Lee , M. , Kim , A. , … Chung , K. S. ( 2017 ). Elasticity‐based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel . Acta Biomaterialia , 64 , 67 – 79 . https://doi.org/10.1016/j.actbio.2017.09.041
Levy , G. , Bomze , D. , Heinz , S. , Ramachandran , S. D. , Noerenberg , A. , Cohen , M. , … Nahmias , Y. ( 2015 ). Long‐term culture and expansion of primary human hepatocytes . Nature Biotechnology , 33 ( 12 ), 1264 – 1271 . https://doi.org/10.1038/nbt.3377
Li , C. Y. , Stevens , K. R. , Schwartz , R. E. , Alejandro , B. S. , Huang , J. H. , & Bhatia , S. N. ( 2014 ). Micropatterned cell‐cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues . Tissue Engineering. Part A , 20 ( 15–16 ), 2200 – 2212 . https://doi.org/10.1089/ten.TEA.2013.0667
Liu , Y. , Li , H. , Yan , S. , Wei , J. , & Li , X. ( 2014 ). Hepatocyte cocultures with endothelial cells and fibroblasts on micropatterned fibrous mats to promote liver‐specific functions and capillary formation capabilities . Biomacromolecules , 15 ( 3 ), 1044 – 1054 . https://doi.org/10.1021/bm401926k
Mak , K. M. , & Mei , R. ( 2017 ). Basement membrane type IV collagen and laminin: An overview of their biology and value as fibrosis biomarkers of liver disease . Anatomical Record (Hoboken) , 300 ( 8 ), 1371 – 1390 . https://doi.org/10.1002/ar.23567
Martinez‐Hernandez , A. , & Amenta , P. S. ( 1995 ). The extracellular matrix in hepatic regeneration . FASEB Journal , 9 ( 14 ), 1401 – 1410 . https://doi.org/10.1096/fasebj.9.14.7589981
McBeath , R. , Pirone , D. M. , Nelson , C. M. , Bhadriraju , K. , & Chen , C. S. ( 2004 ). Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment . Developmental Cell , 6 ( 4 ), 483 – 495 .
Mooney , D. , Hansen , L. , Vacanti , J. , Langer , R. , Farmer , S. , & Ingber , D. ( 1992 ). Switching from differentiation to growth in hepatocytes: Control by extracellular matrix . Journal of Cellular Physiology , 151 ( 3 ), 497 – 505 . https://doi.org/10.1002/jcp.1041510308
Mueller , S. , & Sandrin , L. ( 2010 ). Liver stiffness: A novel parameter for the diagnosis of liver disease . Hepatic Medicine: Evidence and Research , 2 , 49 – 67 . https://doi.org/10.2147/hmer.s7394
Olivero , D. K. , & Furcht , L. T. ( 1993 ). Type IV collagen, laminin, and fibronectin promote the adhesion and migration of rabbit lens epithelial cells in vitro . Investigative Ophthalmology and Visual Science , 34 ( 10 ), 2825 – 2834 .
Oorts , M. , Keemink , J. , Deferm , N. , Adriaensen , R. , Richert , L. , Augustijns , P. , & Annaert , P. ( 2018 ). Extra collagen overlay prolongs the differentiated phenotype in sandwich‐cultured rat hepatocytes . Journal of Pharmacological Toxicological Methods , 90 , 31 – 38 . https://doi.org/10.1016/j.vascn.2017.10.007
Pinkse , G. G. , Voorhoeve , M. P. , Noteborn , M. , Terpstra , O. T. , Bruijn , J. A. , & De Heer , E. ( 2004 ). Hepatocyte survival depends on beta1‐integrin‐mediated attachment of hepatocytes to hepatic extracellular matrix . Liver International , 24 ( 3 ), 218 – 226 . https://doi.org/10.1111/j.1478‐3231.2004.0914.x
Raasch , M. , Fritsche , E. , Kurtz , A. , Bauer , M. , & Mosig , A. S. ( 2018 ). Microphysiological systems meet hiPSC technology—New tools for disease modeling of liver infections in basic research and drug development . Advanced Drug Delivery Reviews , 140 , 51 – 67 . https://doi.org/10.1016/j.addr.2018.06.008
Semler , E. J. , Lancin , P. A. , Dasgupta , A. , & Moghe , P. V. ( 2005 ). Engineering hepatocellular morphogenesis and function via ligand‐presenting hydrogels with graded mechanical compliance . Biotechnology and Bioengineering , 89 ( 3 ), 296 – 307 . https://doi.org/10.1002/bit.20328
Swift , B. , Pfeifer , N. D. , & Brouwer , K. L. ( 2010 ). Sandwich‐cultured hepatocytes: An in vitro model to evaluate hepatobiliary transporter‐based drug interactions and hepatotoxicity . Drug Metabolism Reviews , 42 ( 3 ), 446 – 471 . https://doi.org/10.3109/03602530903491881
Tong , W. H. , Fang , Y. , Yan , J. , Hong , X. , Hari Singh , N. , Wang , S. R. , … Yu , H. ( 2016 ). Constrained spheroids for prolonged hepatocyte culture . Biomaterials , 80 , 106 – 120 . https://doi.org/10.1016/j.biomaterials.2015.11.036
Wang , Y. , Kim , M. H. , Shirahama , H. , Lee , J. H. , Ng , S. S. , Glenn , J. S. , & Cho , N. J. ( 2016 ). ECM proteins in a microporous scaffold influence hepatocyte morphology, function, and gene expression . Scientific Reports , 6 , 37427 . https://doi.org/10.1038/srep37427
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