Hwanggeumchal Sorghum Extracts Suppresses Tumor Growth via Inhibitions of IGF-1R, STAT Family and Jak/STAT Signaling Expression for Human MDA-MB 231 Breast Cancer Cells
인간 유방암세포 MDA-MB 231에 대한 황금찰수수 추출물의 IGF-1R, STAT Family, Jak/STAT Signaling 발현의 억제를 통한 종양 성장의 억제 효과 연구 원문보기

한국약용작물학회 2010년도 심포지엄 및 추계학술발표회, 2010 Oct. 12, 2010년, pp.495 - 496  

Park, Jin-Hee (Konkuk University) ,  Yeo, Min-A (Konkuk University) ,  Kim, Sun-Jin (Konkuk University) ,  Kwon, Jung-Woong (Konkuk University) ,  Song, Sung-Hyun (Konkuk University) ,  Yong, Soo-Jung (Konkuk University) ,  Jang, Mi-So (Konkuk University) ,  Kim, Myong-Jo (College of Agriculture and Life science, Kangwon National University) ,  Park, Dong-Sik (National Institute of Crop Science, RDA) ,  Song, Hong-Keun (Konkuk University) ,  Ahn, Jong-Guk (Konkuk University) ,  Yang, Young-Mok (Konkuk University) ,  Chung, Ill-Min (Konkuk University

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문제 정의

• The objective of this study was to investigate antiproliferative activity and cytotoxicity potential of Hwanggeumchal sorghum extracts on human breast (MDA-MB 231) cancer cell lines in vitro. In this study, we hypothesized that Hwanggeumchal sorghum (Sorghum bicolor Moench) extracts could suppress IGF-1R and IGF-1 expression in invasive breast cancer cells.

가설 설정

• The objective of this study was to investigate antiproliferative activity and cytotoxicity potential of Hwanggeumchal sorghum extracts on human breast (MDA-MB 231) cancer cell lines in vitro. In this study, we hypothesized that Hwanggeumchal sorghum (Sorghum bicolor Moench) extracts could suppress IGF-1R and IGF-1 expression in invasive breast cancer cells.

제안 방법

• Breast cancer cells, MDA-MB 231, were inoculated subcutaneously into nude mice at 5×10⁷cells per mouse to establish tumor xenografts. Imaging of the Tumor-Xenografted Nude Mice Model at the end of the treatment Tumor size growth curves during the treatment calculating the volume size of individual tumors Histological analysis of tumor sections was performed. H&E staining of tumor sections, indicating necrotic areas in tumors.

대상 데이터

• ACN (acetonitrile), 0.1N HCl, Dulbecco’s modified eagle’s medium (DMEM), 10 % fetal bovine serum (FBS) and trypsin-EDTA were purchased from Gibco-BRL (Grand Island, NY, USA).
• MDA-MB 231 tumor xenograftswere established by subcutaneously inoculating 1 × 107 cells into the right flanks of 5-week-old BALB/c nude mice (Orient Bio, Seongnam-Si, Gyeonggi-Do, Korea).

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