[미국특허]
Nasal solution containing a broad spectrum microbicide and a method for its use
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IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61L-009/04
A61K-031/315
A61K-033/14
출원번호
US-0690242
(2003-10-21)
공개번호
US-0086463
(2004-05-06)
발명자
/ 주소
Hansen, Richard L.
대리인 / 주소
Laura F. Shunk
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
The invention provides for a nasal spray which is an aqueous solution containing a broad spectrum microbicide which may be applied in nasal passages in the manner of a decongestant type nose spray in the event of known or suspected exposure of the individual to common cold virus, flu, or other infec
The invention provides for a nasal spray which is an aqueous solution containing a broad spectrum microbicide which may be applied in nasal passages in the manner of a decongestant type nose spray in the event of known or suspected exposure of the individual to common cold virus, flu, or other infective microbial agents. The solution contains active agents which are based on a chlorine or hypochlorite solution, or a solution of chlorine or hypochlorite plus a salt of chloride, bromide or iodide. Alternatively, the solution may contain a bromine solution, or a solution of bromine plus a salt of chloride, bromide or iodide such as sodium chloride, zinc chloride, sodium bromide, zinc bromide, sodium iodide or zinc iodide. The chlorine, hypochlorite, bromine, chloride, bromide, and iodide may originally come from inorganic compounds or organic compounds, which are then dissolved in the water. Further, the solution may contain glycerin or another moisturizing or wetting agent for the nasal mucosa. Zinc gluconate or a zinc halide such as zinc chloride, zinc bromide or zinc iodide may also be included.
대표청구항▼
1. A method of reducing the risk of microbial infection or of combating a microbial infection which is established first in the nasal mucosa area comprising:the application of a nasal spray solution within the nose, said nasal spray solution comprising an aqueous solution having following components
1. A method of reducing the risk of microbial infection or of combating a microbial infection which is established first in the nasal mucosa area comprising:the application of a nasal spray solution within the nose, said nasal spray solution comprising an aqueous solution having following components:a) sodium hypochlorite in a concentration of about 0.5 ppmw to about 50,000 ppmw; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 2. A method of reducing the risk of microbial infection or of combating a microbial infection which is established first in the nasal mucosa area comprising:the application of a nasal spray solution within the nose, said nasal spray solution comprising an aqueous solution having following components:a) chlorine in a concentration of about 0.4 ppmw to about 50,000 pp mw; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about. 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 3. A method of reducing the risk of microbial infection or of combating a microbial infection which is established first in the nasal mucosa area comprising:the application of a nasal spray solution within the nose, said nasal spray solution comprising an aqueous solution having following components:a) bromine in a concentration of about 1 ppmw to about 75,000 ppmw; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 4. A method of reducing the risk of microbial infection or of combating a microbial infection which is established first in the nasal mucosa area comprising:the application of a nasal spray solution within the nose, said nasal spray solution comprising an aqueous solution having following components:a) sodium hypochlorite in a concentration of about 0.5 ppmw to about 50,000 ppmw; b) from about 0.1 ppmw to 160,000 ppmw of a salt selected from one or more of sodium chloride and sodium bromide; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 5. A method of reducing the risk of microbial infection and also of combating an established microbial infection which is established first in the nasal mucosa area comprising the application of a nasal spray solution within the nose, said nasal spray solution comprising an aqueous solution having;a) from about 0.4 ppmw to about 50,000 ppmw of chlorine; and b) from about 0.7 ppmw to 140,000 ppmw of a salt selected from one or more of sodium chloride or sodium bromide; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 6. A method of reducing the risk of microbial infection and of combating a microbial infection which is established first in the nasal mucosa area comprising the application of a nasal spray solution within the nose, said nasal spray solution comprising an aqueous solution having one or more of the following components:a) from about 1 ppmw to about 75,000 ppmw of bromine; and b) from about 0.7 ppmw to 140,000 ppmw of a salt selected from one or more of sodium chloride or sodium bromide; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 7. A nasal spray solution comprising an aqueous solution having following components:a) bromine in a concentration of about 1 ppmw to about 75,000 ppmw; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 8. The nasal spray solution as set forth in claim 7 wherein the bromine is present in a concentration of about 40 to about 8,000 ppmw. 9. The nasal spray solution as set forth in claim 8 wherein the bromine is present in a concentration of about 20 to about 1,000. 10. A nasal spray solution comprising an aqueous solution having following components:a) sodium hypochlorite in a concentration of about 0.5 ppmw to about 50,000 ppmw; b) from about 0.1 ppmw to 160,000 ppmw of a salt selected from one or more of sodium chloride and sodium bromide; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to a bout 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 11. The nasal spray solution as set forth in claim 10 wherein component a) is present in a concentration of from about 5 to about 5,000 ppmw, and component b) is present in a concentration of about 140 to about 55,000 ppmw. 12. The nasal spray solution as set forth in claim 11 wherein component a) is present in a concentration of from about 50 to about 500 ppmw, and component b) is present in a concentration of about 1,400 to about 28,000 ppmw. 13. A nasal spray solution comprising an aqueous solution having the following components;a) from about 0.4 ppmw to about 50,000 ppmw of chlorine; and b) from about 0.7 ppmw to 140,000 ppmw of a salt selected from one or more of sodium chloride or sodium bromide; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 14. The nasal spray solution as set forth in claim 13 wherein component a) is present in a concentration of from about 2 to about 5,000 ppmw, and component b) is present in a concentration of about 140 to about 55,000 ppmw. 15. The nasal spray solution as set forth in claim 14 wherein component a) is present in a concentration of from about 10 to about 500 ppmw, and component b) is present in a concentration of about 1,400 to about 28,000 ppmw. 16. A nasal spray solution comprising an aqueous solution having the following components:a) from about 1 ppmw to about 75,000 ppmw of bromine; and b) from about 0.7 ppmw to 140,000 ppmw of a salt selected from one or more of sodium chloride or sodium bromide; and optionally one or more of zinc gluconate at a concentration of about 1.7 ppmw to about 60,000 ppmw, and glycerine or propylene glycol at a concentration of about 0.01 wt % to about 5 wt %. 17. The nasal spray solution as set forth in claim 16 wherein component a) is present in a concentration of from about 40 to about 8,000 ppmw, and component b) is present in a concentration of about 140 to about 55,000 ppmw. 18. The nasal spray solution as set forth in claim 17 wherein component a) is present in a concentration of from about 20 to about 1,000 ppmw, and component b) is present in a concentration of about 1,400 to about 28,000 ppmw.
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