IPC분류정보
국가/구분 |
United States(US) Patent
공개
|
국제특허분류(IPC7판) |
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출원번호 |
US-0497318
(2006-08-02)
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공개번호 |
US-0031940
(2008-02-07)
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발명자
/ 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
0 |
초록
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A composition includes 10-50 wt. % quercetin; ≧3 wt. % papain; ≧3 wt. % calcium salt; ≧1 wt. % zinc salt; ≧1 wt. % bee pollen; ≧1 wt. % pumpkinseed; ≧0.5 wt. % bromelain; and 0.1 to 1.5 wt. % saw palmetto; wherein the composition is a sustained release composition
A composition includes 10-50 wt. % quercetin; ≧3 wt. % papain; ≧3 wt. % calcium salt; ≧1 wt. % zinc salt; ≧1 wt. % bee pollen; ≧1 wt. % pumpkinseed; ≧0.5 wt. % bromelain; and 0.1 to 1.5 wt. % saw palmetto; wherein the composition is a sustained release composition in tablet or capsule form suitable for oral administration to a human. Methods of making and using the composition are provided.
대표청구항
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What is claimed is: 1. A composition, comprising: 10-50 wt. % quercetin; ≧3 wt. % papain; ≧3 wt. % calcium salt; ≧1 wt. % zinc salt; ≧1 wt. % bee pollen; ≧1 wt. % pumpkinseed; ≧0.5 wt. % bromelain; and 0.1 to 1.5 wt. % saw palmetto; wherein the composition is a s
What is claimed is: 1. A composition, comprising: 10-50 wt. % quercetin; ≧3 wt. % papain; ≧3 wt. % calcium salt; ≧1 wt. % zinc salt; ≧1 wt. % bee pollen; ≧1 wt. % pumpkinseed; ≧0.5 wt. % bromelain; and 0.1 to 1.5 wt. % saw palmetto; wherein the composition is a sustained release composition in tablet or capsule form suitable for oral administration to a human. 2. The composition of claim 1, which comprises about 15-45 wt. % quercetin. 3. The composition of claim 1, which comprises about 30-35 wt. % quercetin. 4. The composition of claim 1, which comprises about 3.1-20 wt. % papain. 5. The composition of claim 1, wherein the calcium salt is selected from the group consisting of dibasic calcium phosphate, tribasic calcium phosphate, calcium fumarate, calcium citrate, calcium maleate, calcium lactate, calcium lactate gluconate, calcium gluconate, calcium acetylsalicylate, calcium ascorbate, calcium carbonate, calcium levulinate, calcium pantothenate, hydrates thereof, and combinations thereof. 6. The composition of claim 1, which comprises about 5-25 wt. % calcium salt, and the calcium salt is dibasic calcium phosphate. 7. The composition of claim 1, wherein the zinc salt is selected from the group consisting of zinc sulfate, zinc acetate, zinc gluconate, zinc lactate, zinc salicylate, zinc stearate, zinc tannate, zinc tartrate, zinc carnosine, zinc L-carnosine, zinc picolinate, zinc citrate, and combinations thereof. 8. The composition of claim 1, which comprises about 2-20 wt. % zinc salt, and the zinc salt is zinc gluconate. 9. The composition of claim 1, which comprises about 2-25 wt. % bee pollen. 10. The composition of claim 1, which comprises about 2-10 wt. % pumpkinseed. 11. The composition of claim 1, which comprises about 0.75-10 wt. % bromelain. 12. The composition of claim 1, which comprises about 1-3 wt. % bromelain. 13. The composition of claim 1, which comprises about 0.5 to 1.25 wt. % saw palmetto. 14. The composition of claim 1, which comprises a sustained release agent selected from the group consisting of gelatin, cellulose acetate phthalate, cellulose ether, cellulose acetate butyrate, cellulose acetate, cellulose diacetate, cellulose triacetate, poly(lactic-co-glycolic acid), beeswax, carnauba wax, glyceryl monostearate, stearic acid, palmitic acid, glyceryl monopalmitate, cetyl alcohol, shellac, zein, silicone elastomer, acrylic resin, acrylic acid copolymer, acrylic acid ester copolymer, methacrylic acid copolymer, methacrylic acid ester copolymer, ethylcellulose, ethylcellulose ether, polyvinylacetate stabilized with povidone and sodium laurylsulfate, polyethylacrylate, polymethyl methacrylate, methylcellulose, hydroxypropyl methylcellulose, copolymers thereof, blends thereof, and a combination thereof. 15. The composition of claim 1, which comprises a sustained release agent in an amount of 0.1 to 10 wt. %. 16. The composition of claim 1, which comprises an ethylcellulose sustained release coating in an amount ranging from 0.1 to 10 wt. %. 17. The composition of claim 15, wherein the sustained release agent is in the form of a coating on the tablet, in admixture with the composition, or a combination of a coating and admixture. 18. The composition of claim 1, further comprising at least one selected from the group consisting of cellulose, stearic acid, magnesium stearate, silicon dioxide, and a combination thereof. 19. A method, comprising contacting: 10-50 wt. % quercetin; ≧3 wt. % papain; ≧3 wt. % calcium salt; ≧1 wt. % zinc salt; ≧1 wt. % bee pollen; ≧1 wt. % pumpkinseed; ≧0.5 wt. % bromelain; 0.1 to 1.5 wt. % saw palmetto; and one or more sustained release agents, to form a sustained release tablet or capsule suitable for oral administration to a human. 20. A method for treating one or more selected from the group consisting of interstitial cystitis, chronic nonbacterial prostatitis, vulvodynia, chronic pelvic pain syndrome, overactive bladder, sexual dysfunction, prostatitis, prostatodynia, urinary incontinence, pain during intercourse, vaginal pain, genitourinary pain not associated with infection, bladder pain, abdominable pain, urinary frequency, category III chronic prostatitis syndrome, category IIIa chronic pelvic pain syndrome, category IIIb chronic pelvic pain syndrome, chronic voiding symptoms not associated with infection, non-bacterial inflammation of prostate, and a combination thereof, comprising administering the composition of claim 1 to a human.
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