Lupin Total Extract Consisting of a Lupin Sugar Extract and a Lupin Peptide Extract, Method for The Production and Use Thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-036/48
A61K-036/185
A61P-017/00
A61P-029/00
A61Q-019/00
출원번호
US-0547031
(2005-04-04)
공개번호
US-0050458
(2008-02-28)
우선권정보
FR-0403693(2004-04-08)
국제출원번호
PCT/FR05/000810
(2005-04-04)
발명자
/ 주소
Choulot,Jean Christophe
Piccirilli,Antoine
Piccardi,Nathalie
Msika,Phillippe
Paul,Francois
출원인 / 주소
Laboratoires Expanscience
대리인 / 주소
FOLEY AND LARDNER LLP
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
The invention relates to a composition comprising a lupin total extract consisting of a lupin sugar extract, comprising at least 50% galactooligosaccharides by weight, in relation to the weight of dry matter, and a lupin peptide extract. The composition can also contain a chromane derivative or a ch
The invention relates to a composition comprising a lupin total extract consisting of a lupin sugar extract, comprising at least 50% galactooligosaccharides by weight, in relation to the weight of dry matter, and a lupin peptide extract. The composition can also contain a chromane derivative or a chromene derivative. The invention also relates to a pharmaceutical and/or cosmetic composition comprising said lupin total extract, used advantageously as an anti-inflammatory agent, which repairs the cutaneous barrier and heals, used particularly in the prevention and/or treatment of erythemas.
대표청구항▼
1-19. (canceled) 20. A composition comprising a total lupin extract consisting of a lupin sugar extract, which comprises at least 50% by weight of galacto-oligosaccharides, based on the weight of the dry material of the sugar extract, and a lupin peptide extract. 21. The composition accordi
1-19. (canceled) 20. A composition comprising a total lupin extract consisting of a lupin sugar extract, which comprises at least 50% by weight of galacto-oligosaccharides, based on the weight of the dry material of the sugar extract, and a lupin peptide extract. 21. The composition according to claim 20, wherein the sugar extract comprises 55-90% by weight of galacto-oligosaccharides, based on the weight of the dry material of the sugar extract. 22. The composition according to claim 20, wherein the galacto-oligosaccharides are selected from the group formed by verbascose, stachyose and raffinose. 23. The composition according to claim 20, wherein the sugar extract is obtained by a method comprising the following steps: a) extraction of lipids from the lupin seed by means of a suitable solvent and recovery of the protein and saccharide fractions of the lupin; and then b) from the fraction recovered in step a), separation of the fraction comprising the lupin sugars by ultrafiltration and recovery of said saccharide fraction; and c) if need be, physical refining of the fraction comprising the lupin sugars, recovered subsequently to step b); d) obtaining subsequently to step b) or c), a lupin sugar extract, highly enriched in galacto-oligosaccharides. 24. The composition according to claim 20, wherein the mass ratio between the galacto-oligosaccharides and the lupin peptides is between 1 and 10. 25. The composition according to claim 20, wherein the mass ratio between the galacto-oligosaccharides and the lupin peptides is between 2 and 3. 26. The composition according to claim 20, wherein the peptide extract comprises at least 50% of peptides. 27. The composition according to claim 20, wherein the lupin peptide extract is able to be obtained by a method comprising the following steps: i) extraction of the lipids of lupin seed by means of a suitable solvent and recovery of the protein and saccharide fractions of the lupin; ii) extraction of the protein fraction by ultrafiltration and recovery of said protein fraction; iii) enzymatic hydrolysis of the proteins, recovered subsequently to step ii), into peptides; and iv) purification by ultrafiltration of the peptides obtained subsequently to step iii); v) concentration of the extract obtained subsequently to step iv), by partial or total evaporation of the water and recovery of the peptide extract. 28. The composition according to claim 20, wherein the lupin is selected from the group consisting of the varieties lupinus angustifolius, lupinus albus, lupinus luteus, and lupinus mutabilis. 29. The composition according to claim 20, wherein the lupin is lupinus albus genus. 30. The composition according to claim 20, further comprising a chromane or chromene derivative described by the general formula (I) wherein: the dotted line represents an additional bond or a lack of additional bond; R1 represents a hydrogen, a hydroxy, a methoxy, a phenyl, a phenyl substituted with 1, 2 or 3 hydroxy groups, a phenyl substituted with 1, 2 or 3 methoxy groups or a phenyl substituted with a flavone of formula: R2 represents a hydrogen, a hydroxy, a methoxy, a phenyl, a phenyl, a phenyl substituted with 1, 2 or 3 hydroxy groups, or a phenyl substituted with 1, 2 or 3 methoxy groups or else, R1 and R2 together form a benzene ring; R3 represents a hydrogen, a hydroxy, or an oxo; R4, R5 and R6 either identical or different, represent a hydrogen, a hydroxy, a methoxy, a phenyl, a phenyl substituted with 1, 2 or 3 hydroxy groups, or a phenyl substituted with 1, 2 or 3 methoxy groups. 31. The composition according to claim 30, wherein the chromane or chromene derivative is selected from the group consisting of chromones, xanthones and flavonoids. 32. The composition according to claim 30, wherein the chromane or chromene derivative is a flavonoid. 33. The composition according to claim 32, wherein the flavonoid is selected from the group consisting of flavones, flavonols, dihydro-2,3-flavonols, flavanones, flavanols, flavanediols, isoflavanoids and biflavonoids. 34. The composition according to claim 33, wherein the flavonoid is an isoflavone, or a mixture of isoflavones. 35. The composition according to claim 34, wherein the isoflavone is selected in the group consisting of genistein, daidzein and glycitein. 36. A cosmetic composition comprising a composition according to claim 20 and a cosmetically acceptable excipient. 37. A pharmaceutical composition comprising a composition according to claim 20 and a pharmaceutically acceptable excipient. 38. A method for treating inflammatory reactions comprising the administration of an effective amount of a composition comprising a lupin sugar extract, which comprises at least 50% by weight, based on the weight of the dry material, of galacto-oligosaccharides to a patient in need thereof. 39. A method for preventing and/or treating a disease selected from the group consisting of erythemas, rosacea as well as any cutaneous inflammation consecutive i) to an external aggression and/or ii) to a dysfunction of the metabolism or the structure of the skin comprising the administration of an effective amount of a pharmaceutical composition according to claim 37 to a patient in need thereof. 40. The method according to claim 39, for preventing and/or treating diaper rashes or solar erythemas. 41. A treatment method for sensitive, irritated, intolerant, allergy-prone, aged, skins and/or mucosae, with a disorder of the skin barrier, with skin red spots, or having a non-pathological immunological disorder or disequilibrium, related to intrinsic, extrinsic or hormonal aging, consisting of applying a composition according to claim 36 on the skin and/or the mucosae to a patient in need thereof. 42. A cosmetic treatment method for controlling the pH of the skin, consisting of applying a composition according to claim 36 on the skin and/or the mucosae to a patient in need thereof. 43. A treatment method for repairing the surface condition of the skin, consisting of applying a composition according to claim 36 on the skin. 44. The method according to claim 43 for repairing lesions of the skin barrier.
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