Antioxidant and Fe2+ Chelating Properties of Herbal Extracts
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-036/38
A61K-036/185
A61K-031/56
A61P-035/00
A61P-009/00
A61P-031/00
A61P-001/00
A61P-025/00
A61K-036/16
출원번호
US-0090957
(2006-10-16)
공개번호
US-0292733
(2008-11-27)
국제출원번호
PCT/IB06/002880
(2006-10-16)
발명자
/ 주소
Sutherland,Sharla K.
Shan,Jacqueline J.
출원인 / 주소
Sutherland,Sharla K.
Shan,Jacqueline J.
대리인 / 주소
ROTHWELL, FIGG, ERNST & MANBECK, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
The present invention is directed to antioxidative and antiproliferative agents containing North American ginseng (proprietary extract HT1001) alone or in combination with Ginkgo biloba (GB), Saint John's Wort (SJW), ginkgolides, flavonoids, ginsenosides, hypericin, and/or hyperforin. The antioxidat
The present invention is directed to antioxidative and antiproliferative agents containing North American ginseng (proprietary extract HT1001) alone or in combination with Ginkgo biloba (GB), Saint John's Wort (SJW), ginkgolides, flavonoids, ginsenosides, hypericin, and/or hyperforin. The antioxidative and antiproliferative agents according to the present invention show significant inhibition of Fe2+-catalyzed lipid peroxidation and Fe2+ chelation activity, the ability to scavenge hydroxyl free radicals, the ability to reduce neuroblastoma cell numbers, and/or the ability to promote neurite outgrowth. These effects are consistent with the behavior of Fe2+ chelators and the variance in both type and magnitude of effects exerted by the chemical components suggests a synergistic mechanism of action.
대표청구항▼
What is claimed is: 1-4. (canceled) 5. A method for treating oxidative stress, comprising administering, in an amount effective to reduce oxidative stress, a pharmaceutical composition comprising HT1001, an American ginseng extract that has a total ginsenoside content which is about 25-50% by wei
What is claimed is: 1-4. (canceled) 5. A method for treating oxidative stress, comprising administering, in an amount effective to reduce oxidative stress, a pharmaceutical composition comprising HT1001, an American ginseng extract that has a total ginsenoside content which is about 25-50% by weight, in combination with at least one agent selected from the group consisting of Ginkgo biloba, Saint John's Wort, ginkgolides, flavonoids, ginsenosides, hypericin, and hyperforin, to a patient in need of such treatment. 6. The method according to claim 5, wherein said oxidative stress is due to cancer, Alzheimer's disease, tuberculosis, Parkinson's disease, sickle cell, Wilson, liver damage, beta-thalassemia, heart disease, multiple sclerosis, inflammatory bowel disease (Crohn's disease and ulcerative colitis), infection, neoplasia, cardiomyopathy, or arthropathy. 7. A method for treating iron overload comprising administering, in an amount effective to reduce iron overload, a pharmaceutical composition comprising HT1001, an American ginseng extract that has a total ginsenoside content which is about 25-50% by weight, in combination with at least one agent selected from the group consisting of Ginkgo biloba, Saint John's Wort, ginkgolides, flavonoids, ginsenosides, hypericin, and hyperforin, to a patient in need of such treatment. 8. The method according to claim 7, wherein said iron overload is due to cancer, Alzheimer's disease, tuberculosis, Parkinson's disease, sickle cell, Wilson, liver damage, beta-thalassemia, heart disease, multiple sclerosis, inflammatory bowel disease (Crohn's disease and ulcerative colitis), infection, neoplasia, cardiomyopathy, or arthropathy. 9. A method for promoting neurite outgrowth comprising administering, in an amount effective to promote neurite outgrowth, a pharmaceutical composition comprising HT1001, an American ginseng extract that has a total ginsenoside content which is about 25-50% by weight, in combination with at least one agent selected from the group consisting of Ginkgo biloba, ginkgolides, flavonoids, and ginsenosides, to a patient in need of such treatment. 10. The method according to claim 9, wherein promoting neurite outgrowth is needed to treat Alzheimer's disease, Parkinson's disease, infection, and neuroblastoma.
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