[미국특허]
EMBEDDED ENZYMES IN POLYMERS TO REGULATE THEIR DEGRADATION RATE
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IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-038/46
A61K-038/43
출원번호
US-0187949
(2008-08-07)
공개번호
US-0162337
(2009-06-25)
발명자
/ 주소
Gross, Richard A.
Dave, Rachna
Martin, Arthur
대리인 / 주소
SMITH, GAMBRELL & RUSSELL
인용정보
피인용 횟수 :
0인용 특허 :
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초록
A biodegradable material, capable of carrying a bioactive agent, comprising a polymer matrix and an enzyme capable of degrading the polymer matrix to enable the release of the bioactive agent.
대표청구항▼
What is claimed is: 1. A method for preparing an enzyme-embedded polymer material comprising the steps of: (a) selecting a polymer; (b) selecting an enzyme capable of degrading the polymer; (c) incorporating the enzyme selected to degrade the polymer into a polymer matrix formed from the polymer; a
What is claimed is: 1. A method for preparing an enzyme-embedded polymer material comprising the steps of: (a) selecting a polymer; (b) selecting an enzyme capable of degrading the polymer; (c) incorporating the enzyme selected to degrade the polymer into a polymer matrix formed from the polymer; and (d) incorporating an active agent into the polymer matrix. 2. The method as claimed in claim 1, wherein the polymer matrix is constructed from a polymer selected from the group consisting of poly(ε-caprolactone), poly(lactic acid) stereocopolymer, polyesters, polyhydroxyalkanoates, polysaccharides, polycarbonates, polyamides, oligopeptides, pseudopolyamino acids, peptides of higher molecular weight, protein-based materials, polymers prepared from fatty acids with degradable linkages, polyurethanes built from polyols that contain degradable units, mixed linkage polymers that contain various fractions of the above polymer building blocks, and vinyl polymers. 3. The method as claimed in claim 1, wherein the enzyme is selected from the group consisting of lipases, proteinases, hydrolases, and cutinases. 4. The method as claimed in claim 1, wherein the polymer matrix is constructed from poly(ε-caprolactone) and the enzyme is a lipase. 5. The method as claimed in claim 4, wherein the enzyme is Candida antartica Lipase B. 6. The method as claimed in claim 1, wherein the polymer matrix is constructed from a poly(lactic acid) stereocopolymer and the enzyme is a serine proteinase. 7. The method as claimed in claim 6, wherein the enzyme is Proteinase K. 8. The method as claimed in claim 1, wherein the polymer is a natural polymer. 9. The method as claimed in claim 1, wherein the polymer is a modified natural polymer. 10. The method as claimed in claim 1, wherein the polymer is a synthetic polymer. 11. The method as claimed in claim 1, wherein the active agent is incorporated within the polymer matrix by enzyme-embedded material synthesis. 12. The method as claimed in claim 12, wherein: as the polymer matrix is being synthesized, hydrolytic enzymes become associated with the polymer matrix and are incorporated within the polymer matrix; and simultaneously, the active agent is incorporated within the polymerization reaction. 13. The method as claimed in claim 1, wherein the active agent is selected from the group consisting of bioactive agents, pharmaceutical compositions or compounds, nutraceutical compositions or compounds, nutritional components, biologically active components, flavorants, fragrances, detergents, cosmetics, and surface-active compositions. 14. The method as claimed in claim 13, wherein the active agent is a pharmaceutical compounds selected from the group consisting of antibiotics, analgesics, vaccines, anti-inflammatory agents, anti-depressants, anti-viral agents, anti-tumor agents, enzyme inhibitors, formulations containing zidovudine, macromolecular polypeptides, aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents, HIV protease inhibitors, viruses, steroids, compositions to promote growth such as hormones, other growth stimulating agents, and mixtures thereof. 15. The method as claimed in claim 13, wherein the active agent is a nutraceutical components selected from the group consisting of antioxidants, phytochemicals, hormones; vitamins; pantothenate; folic acid; pro-vitamins; minerals; microorganisms; prebiotics; probiotics; trace elements; essential and/or highly unsaturated fatty acids; nutritional supplements; enzymes; pigments; oligopeptides; dipeptides; amino acids; and mixtures thereof. 16. The method as claimed in claim 13, wherein the active agent is a biologically active components selected from the group consisting of herbicides, pesticides, insecticides, rodenticides, fungicides, and mixtures thereof, and hormones, fertilizers, other growth stimulating agents, and mixtures thereof. 17. A method for preparing an enzyme-embedded polymer material comprising the steps of: (a) selecting a polymer from the group consisting of poly(ε-caprolactone) and poly(lactic acid) stereocopolymer; (b) selecting an enzyme from the group consisting of lipases and proteinases that is capable of degrading the selected polymer; (c) incorporating the enzyme selected to degrade the polymer into a polymer matrix formed from the polymer; and (d) incorporating an active agent into the polymer matrix. 18. The method as claimed in claim 17, wherein the enzyme is selected from the group consisting of Candida antartica Lipase B and Proteinase K. 19. The method as claimed in claim 17, wherein the active agent is incorporated within the polymer matrix by enzyme-embedded material synthesis, wherein: as the polymer matrix is being synthesized, hydrolytic enzymes become associated with the polymer matrix and are incorporated within the polymer matrix; and simultaneously, the active agent is incorporated within the polymerization reaction. 20. The method as claimed in claim 17, wherein the active agent is selected from the group consisting of bioactive agents, pharmaceutical compositions or compounds, nutraceutical compositions or compounds, nutritional components, biologically active components, flavorants, fragrances, detergents, cosmetics, and surface-active compositions.
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