TYPE III SECRETION PATHWAY IN AEROMONAS SALMONICIDA AND USES THEREFOR
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-039/395
A61K-039/395
A61K-039/02
A61K-039/02
A61K-031/7088
A61K-031/7088
A61P-031/04
A61P-031/00
출원번호
US-0397801
(2009-03-04)
공개번호
US-0226462
(2009-09-10)
발명자
/ 주소
Frey, Joachim
Stuber, Katja
Thornton, Julian C.
Kuzyk, Michael A.
Burian, Jan
대리인 / 주소
WOMBLE CARLYLE SANDRIDGE & RICE, PLLC
인용정보
피인용 횟수 :
0인용 특허 :
0
초록
Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
대표청구항▼
We claim: 1. A method for reducing the susceptibility of a fish to an infection, the method comprising administering to the fish at least one epitope or epitopic region of an Aeromonas salmonicida polypeptide selected from the group consisting of: Acr1, Acr2, Acr3, Acr4, AcrD, AcrR, AcrG, AcrV, and
We claim: 1. A method for reducing the susceptibility of a fish to an infection, the method comprising administering to the fish at least one epitope or epitopic region of an Aeromonas salmonicida polypeptide selected from the group consisting of: Acr1, Acr2, Acr3, Acr4, AcrD, AcrR, AcrG, AcrV, and AcrH. 2. The method of claim 1, wherein the Aeromonas salmonicida polypeptide is AcrV. 3. The method of claim 1, wherein the infection is a virulent strain of Aeromonas salmonicida 4. The method of claim 1, wherein administering comprises providing to the fish an immunogenic composition comprising the at least one epitope or epitopic region. 5. The method of claim 4, wherein the immunogenic composition further comprises a pharmaceutically acceptable carrier. 6. The method of claim 1, wherein administering comprises providing to the fish a polynucleotide having a sequence encoding the at least one epitope or epitopic region. 7. The method of claim 6, wherein the polynucleotide is a plasmid. 8. The method of claim 6, wherein the polynucleotide is an expression vector. 9. The method of claim 1, wherein the administering comprises intraperitoneal, intramuscular, intradermal, intracellular, spray, immersion, oral, or gill. 10. A method for reducing the susceptibility of a fish to infection, the method comprising administering to the fish a polypeptide having an amino acid sequence selected from the group consisting of: SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9. 11. The method of claim 10, wherein the infection is a virulent strain of Aeromonas salmonicida. 12. The method of claim 10, wherein the amino acid sequence is SEQ ID NO:1. 13. The method of claim 10, wherein administering comprises providing to the fish an immunogenic composition comprising the polypeptide. 14. The method of claim 13, wherein the immunogenic composition further comprises a pharmaceutically acceptable carrier. 15. The method of claim 10, wherein administering comprises providing to the fish a polynucleotide having a sequence encoding the polypeptide. 16. The method of claim 15, wherein the polynucleotide is a plasmid. 17. The method of claim 13, wherein the polynucleotide is an expression vector. 18. The method of claim 9, wherein the administering comprises intraperitoneal, intramuscular, intradermal, intracellular, spray, immersion, oral, or gill. 19. A method for protecting a fish from a toxic effect of a virulent strain of Aeromonas salmonicida, the method comprising administering an antiserum directed against at least one epitope or epitopic region of an Aeromonas salmonicida polypeptide selected from the group consisting of: Acr1, Acr2, Acr3, Acr4, AcrD, AcrR, AcrG, AcrV, and AcrH. 20. The method of claim 19, wherein the Aeromonas salmonicida polypeptide is AcrV.
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