Composition and Methods for Treating Hair Loss
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-031/506
A61P-031/10
A61K-031/496
A61P-017/14
출원번호
US-0440304
(2012-04-05)
공개번호
US-0258972
(2012-10-11)
발명자
/ 주소
Rafi, Asif
Katz, Roger M.
출원인 / 주소
Rafi, Asif
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
A method for treating hair loss caused by androgenic alopecia and/or male pattern baldness. The method, which not only slows hair loss but causes hair re-growth, includes approximately daily application to a subject's scalp of a novel composition comprising finasteride (Propecia® or Proscar®), dutas
A method for treating hair loss caused by androgenic alopecia and/or male pattern baldness. The method, which not only slows hair loss but causes hair re-growth, includes approximately daily application to a subject's scalp of a novel composition comprising finasteride (Propecia® or Proscar®), dutasteride (Avodart®), and minoxidil (Rogaine®) as active ingredients in a hypoallergenic cream-based vehicle, preferably coupled with daily ingestion of 1 mg per day of finasteride (Propecia® or Proscar®), application to the scalp of 5% minoxidil (Rogaine®) foam approximately once per day, and use of a ketoconazole-containing shampoo (e.g., Nizoral®) approximately 2-3 times per week. The method described herein also resolves scalp dermatitis in atopic subjects suffering therefrom. A method for making the novel composition is also provided.
대표청구항▼
1. A composition for treating hair loss and stimulating hair growth comprising: a. a pharmaceutically effective amount of a first inhibitor of Type I 5-alpha reductase, Type II 5-alpha reductase, or both;b. a pharmaceutically effective amount of a second inhibitor of Type I 5-alpha reductase, Type I
1. A composition for treating hair loss and stimulating hair growth comprising: a. a pharmaceutically effective amount of a first inhibitor of Type I 5-alpha reductase, Type II 5-alpha reductase, or both;b. a pharmaceutically effective amount of a second inhibitor of Type I 5-alpha reductase, Type II 5-alpha reductase, or both;c. a pharmaceutically effective amount of a vasodilator that reduces hair loss and/or stimulates hair growth;d. approximately 30-60% by volume of a cream vehicle; ande. approximately 30-60% by volume water. 2. The composition for treating hair loss and stimulating hair growth of claim 1, wherein the first inhibitor of Type I 5-alpha reductase, Type II 5-alpha reductase, or both comprises finasteride. 3. The composition for treating hair loss and stimulating hair growth of claim 1, wherein the second inhibitor of Type I 5-alpha reductase, Type II 5-alpha reductase, or both comprises dutasteride. 4. The composition for treating hair loss and stimulating hair growth of claim 1, wherein the vasodilator comprises minoxidil. 5. The composition for treating hair loss and stimulating hair growth of claim 1, wherein the cream vehicle is hypoallergenic. 6. The composition for treating hair loss and stimulating hair growth of claim 2, wherein the second inhibitor of Type I 5-alpha reductase, Type II 5-alpha reductase, or both comprises dutasteride. 7. The composition for treating hair loss and stimulating hair growth of claim 2, wherein the vasodilator comprises minoxidil. 8. The composition for treating hair loss and stimulating hair growth of claim 3, wherein the vasodilator comprises minoxidil. 9. The composition for treating hair loss and stimulating hair growth of claim 6, wherein the vasodilator comprises minoxidil. 10. The composition for treating hair loss and stimulating hair growth of claim 2, wherein the cream vehicle is hypoallergenic. 11. The composition for treating hair loss and stimulating hair growth of claim 3, wherein the cream vehicle is hypoallergenic. 12. The composition for treating hair loss and stimulating hair growth of claim 4, wherein the cream vehicle is hypoallergenic. 13. The composition for treating hair loss and stimulating hair growth of claim 6, wherein the cream vehicle is hypoallergenic. 14. The composition for treating hair loss and stimulating hair growth of claim 9, wherein the cream vehicle is hypoallergenic. 15. A method for making the composition of claim 14, said method capable of upward or downward scaling, comprising: a. mixing approximately 0.1 mg/ml dutasteride and approximately 0.5 mg/ml finasteride in approximately 20 ml of water at room temperature for approximately 24-48 hours;b. adding approximately 8.0 ml of 5% minoxidil solution and approximately 21 ml of hypoallergenic cream vehicle to the 0.1 mg/mi dutasteride and approximately 0.5 mg/mi finasteride in approximately 20 ml of water for a combination totaling approximately 50 ml;c. mixing the combination for approximately 24-72 hours;d. blending the combination into a cream; and,e. storing the composition under refrigeration for subsequent use. 16. A method for treating hair loss and stimulating hair growth comprising: applying to a scalp of a subject at least once every other day the composition of claim 1. 17. The method for treating hair loss and stimulating hair growth of claim 16, further comprising: applying to the scalp of the subject, at least twice-weekly, an anti-fungal shampoo. 18. The method for treating hair loss and stimulating hair growth of claim 16, further comprising: ingesting orally, once daily, a 5-alpha reductase inhibitor. 19. The method for treating hair loss and stimulating hair growth of claim 16, further comprising: applying to the scalp of the subject, at least thrice-weekly, minoxidil foam. 20. The method for treating hair loss and stimulating hair growth of claim 17, wherein the anti-fungal shampoo is ketoconazole. 21. The method for treating hair loss and stimulating hair growth of claim 18, wherein the 5-alpha reductase inhibitor is finasteride. 22. The method for treating hair loss and stimulating hair growth of claim 19, wherein the anti-fungal shampoo is ketoconazole. 23. The method for treating hair loss and stimulating hair growth of claim 19, wherein the 5-alpha reductase inhibitor is finasteride. 24. The method for treating hair loss and stimulating hair growth of claim 20, wherein the 5-alpha reductase inhibitor is finasteride. 25. The method for treating hair loss and stimulating hair growth of claim 22, wherein the 5-alpha reductase inhibitor is finasteride.
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