POLYELECTROLYTE COMPLEX GELS AND SOFT TISSUE AUGMENTATION IMPLANTS COMPRISING THE SAME
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IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-035/12
A61P-013/00
A61K-038/02
A61K-038/18
A61K-047/42
출원번호
US-0117477
(2011-05-27)
공개번호
US-0301436
(2012-11-29)
발명자
/ 주소
YANG, JEN-CHANG
LEE, SHENG-YANG
HUANG, HAW-MING
JI, DIAN-YU
WU, HONG-DA
MA, CHEN-FENG
출원인 / 주소
TAIPEI MEDICAL UNIVERSITY
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
The invention provides a polyelectrolyte complex gel comprising a chitosan and a γ-polyglutamic acid (γ-PGA) having a molecular weight from about 1 kDa to about 400 kDa or the salt thereof, wherein the chitosan and the γ-PGA are swollen with an aqueous solution. Also provided is a soft tissue augmen
The invention provides a polyelectrolyte complex gel comprising a chitosan and a γ-polyglutamic acid (γ-PGA) having a molecular weight from about 1 kDa to about 400 kDa or the salt thereof, wherein the chitosan and the γ-PGA are swollen with an aqueous solution. Also provided is a soft tissue augmentation implant, comprising a polyelectrolyte complex gel of the invention as a carrier or a filler and an optional additive. The polyelectrolyte complex gel and the soft tissue augmentation implant containing the same has long degradation time and better supportability so as to provide good maintenance for soft tissue.
대표청구항▼
1. A polyelectrolyte complex gel comprising a chitosan, a γ-polyglutamic acid (γ-PGA) having a molecular weight from about 1 kDa to about 400 kDa or the salt thereof and an aqueous solution, wherein the chitosan and the γ-PGA are swollen with the aqueous solution. 2. The polyelectrolyte complex gel
1. A polyelectrolyte complex gel comprising a chitosan, a γ-polyglutamic acid (γ-PGA) having a molecular weight from about 1 kDa to about 400 kDa or the salt thereof and an aqueous solution, wherein the chitosan and the γ-PGA are swollen with the aqueous solution. 2. The polyelectrolyte complex gel of claim 1, wherein the molecular weight of γ-PGA ranges from about 1 kDa to about 350 kDa, about 1 kDa to about 300 kDa, about 1 kDa to about 250 kDa, about 1 kDa to about 200 kDa, about 1 kDa to about 150 kDa, about 1 kDa to about 100 kDa, about 1 kDa to about 100 kDa, about 1 kDa to about 50 kDa, about 5 kDa to 350 kDa, about 5 kDa to about 300 kDa, about 5 kDa to about 250 kDa, about 5 kDa to about 200 kDa, about 5 kDa to about 150 kDa, about 5 kDa to about 100 kDa, about 5 kDa to about 50 kDa, about 10 kDa to about 400 kDa, about 10 kDa to about 350 kDa, about 10 kDa to about 300 kDa, about 10 kDa to about 250 kDa, about 10 kDa to about 200 kDa, about 10 kDa to about 150 kDa, about 10 kDa to about 100 kDa, about 10 kDa to about 50 kDa, about 50 kDa to about 400 kDa, about 50 kDa to about 350 kDa, about 50 kDa to about 300 kDa, about 50 kDa to about 250 kDa, about 50 kDa to about 250 kDa, about 50 kDa to about 200 kDa, about 50 kDa to about 150 kDa, about 50 kDa to about 100 kDa, about 100 kDa to about 400 kDa, about 100 kDa to about 350 kDa, about 100 kDa to about 300 kDa, about 100 kDa to about 250 kDa, about 100 kDa to about 200 kDa, or about 100 kDa to about 150 kDa, or any mixture thereof. 3. The polyelectrolyte complex gel of claim 1, wherein γ-PGA is in H form or salt form. 4. The polyelectrolyte complex gel of claim 1, wherein the salt of γ-PGA is sodium salt, potassium salt, calcium salt or magnesium salt. 5. The polyelectrolyte complex gel of claim 1, wherein the chitosan has the molecular weight more than 100 kDa. 6. The polyelectrolyte complex gel of claim 1, wherein the chitosan has the molecular weight ranging from about 100 kDa to about 2000 kDa, about 100 kDa to about 1500 kDa, about 100 kDa to about 1000 kDa, about 200 kDa to about 2000 kDa, about 200 kDa to about 1500 kDa, about 200 kDa to about 1500 kDa, about 100 kDa to about 700 kDa, about 100 kDa to about 400 kDa, or about 400 kDa to about 700 kDa, or any mixture thereof. 7. The polyelectrolyte complex gel of claim 1, wherein the amounts of the chitosan and γ-PGA or a salt thereof range from about 0.1 wt % to about 10 wt % and about 0.1 wt % to about 20 wt %. 8. The polyelectronic gel of claim 1, wherein the amount of the chitosan is about 0.5 wt % to about 10 wt %, about 1 wt % to about 10 wt %, about 2 wt % to about 10%, about 0.5 wt % to about 5 wt %, about 1 wt % to about 5 wt %, about 2 wt % to about 5 wt %. 9. The polyelectronic gel of claim 1, wherein the amount of γ-PGA or a salt thereof is about 0.5 wt % to about 20 wt %, about 1 wt % to about 20 wt %, about 1 wt % to about 15 wt %, about 1 wt % to about 10 wt % or about 1 wt % to about 5 wt %. 10. The polyelectronic gel of claim 1, which can be used as a filler or a carrier for soft tissue augmentation. 11. The polyelectronic gel of claim 1, wherein the aqueous solution has a weak acidic pH. 12. The polyelectronic gel of claim 1, wherein the aqueous solution is aqua or aqueous alcohol. 13. The polyelectronic gel of claim 12, wherein the aqueous alcohol aqua, glycerol, isopropyl alcohol, ethanol, and ethylene glycol, or mixtures thereof. 14. A soft tissue augmentation implant comprising a polyelectrolyte complex gel of claim 1 and a carrier or a filler and an optional additive. 15. The soft tissue augmentation implant of claim 14, wherein the carrier is selected from the group consisting of Acacia gel, Carbomer copolymer and homopolymer, Carbomer interpolymer, hydrogel, polysaccharide, macrocyclic polycsaccharide, oligosaccharide, starch, acetyl starch, cellulose, cellulose derivatives, methylcellulose, carboxymethylcellulose sodium, carboxymethylcellulose (CMC), ethyl (hydroxyethyl) cellulose (EHEC), ethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose (HPMC), ethylcellulose, alkyl cellulose, alkoxy cellulose, hydroxy ethyl cellulose, copovidone, povidone, gelatin, Guar gum, hypromellose, hypromellose acetate succinate, maltodextrin, syrup, agar, alamic acid, aluminum monostearate, attapulgite, gellan gum, hypromellose, maltodextrin, pectin, propylene glycol alginate, sodium alginate, calcium alginate, colloidal silicon dioxide, tragacanth, xanthan gum, lecithin, tridobenzene derivatives, iohexyl, iopamidol, iopentol, sucrose, carrageenan, agarose, mannitol, saccharin sodium, sorbitol, cephalin, acetylenic diol, Carbowax, polyorgano sulfonic acid, alkoxylated surfactants, alkylphenol ethoxylates, ethoxylated fatty acids, alcohol ethoxylates, alcohol alkoxylates, polyethylene oxide, poly(propylene oxide), poly(ethylene glycol), poly(propylene glycol), poly vinyl alcohol (PVA) polymer or copolymer, polyacrylamine, poly(vinylcarboxylic acid), polymethacrylic acid, polyacrylic acid polymer or copolymer, poly amino acids, albumin, collagen, fibrin, bioglue, cellulosics, Carbopol, Poloxamer, Pluronic, Tetronics, PEO-PPO-PEO triblocks copolymer, Tetrafunctional block copolymer of PEO-PPO condensed with ethylenadiamine, polyHEMA polymer or copolymer, Hypan polymer or copolymer, starch glycolate polymer or copolymer salt, polyoxyalkylene ether, polyvinyl pyridine, polylysine, polyarginine, poly aspartic acid and poly glutamic acid, polytetramethylene oxide, poly(hydroxy ethyl acrylate), poly(hydroxy ethyl methacrylate), methoxylated pectin gels, cellulose acetate phthalate, organic oils, B-glucan, polysorbate, lactic acid ester, caproic acid ester, hyaluronic acid, dextrin, dextran, dextrose, and mixture of the above. 16. The soft tissue augmentation implant of claim 14, wherein the filler is polysaccharides (such as hyaluronic acid (HA)), inorganic salt, collagen, polyalcohols, hydroxyapatite (such as calcium hydroxyapatite), silicone and gelatin, polymethylmethacrylate or poly-L-lactic acid (PLLA), carboxymethylcellulose, cross-linked CMC hydrogel, fat or silk protein. 17. The soft tissue augmentation implant of claim 16, wherein the inorganic salt is calcium phosphate particle, calcium silicate particle, calcium carbonate particle, aluminum oxide particle, zirconium oxide particle, hydroxyapatite particle, zirconium oxide containing hydroxyapatite particle, calcium pyrophosphate particle, tetracalcium phosphate particle, tricalcium phosphate particle, octacalcium phosphate particle, fluorapatite (Ca10(PO4)6F2) particle, calcium apatite particle or a mixture thereof. 18. The soft tissue augmentation implant of claim 16, wherein the inorganic salt is calcium phosphate particle, zirconium oxide particle, hydroxyapatite particle, zirconium oxide containing hydroxyapatite particle or a mixture thereof. 19. The soft tissue augmentation implant of claim 16, wherein the inorganic salt is calcium phosphate particle. 20. The soft tissue augmentation implant of claim 16, wherein the inorganic salt is hydroxyapatite particle. 21. The soft tissue augmentation implant of claim 14, wherein the additive is cell, bioactive substance or protein. 22. The soft tissue augmentation implant of claim 21, wherein the cells are adipose (fat) cells, embryonic stem cells, mesenchymal stem cells, neural stem cells, preadipocytes, adipose derivated stem cells or dental pulp stem cells. 23. The soft tissue augmentation implant of claim 21, wherein the bioactive substance is a growth factor. 24. The soft tissue augmentation implant of claim 23, wherein the growth factors are epidermal growth factor (EGF), fibroblast growth factor (FGF), nerve growth factor (NGF) or a mixture thereof.
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