The invention provides fabricated PVA-hydrogels, PVA-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the PVA-hydrogels, or the PVA-hydrogel-containing compositions to treat a subject in need. Methods of cross-linkin
The invention provides fabricated PVA-hydrogels, PVA-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the PVA-hydrogels, or the PVA-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-hydrogels, and cross-linked PVA-hydrogel-containing compositions also are disclosed herein.
대표청구항▼
1. A method of making a PVA-hydrogel comprising: a) contacting an aqueous solution of poly(vinyl alcohol) (PVA) with an aqueous solution of poly(acrylic acid) (PAA) at a temperature above room temperature, thereby forming a homogenous PVA-PAA solution;b) cooling the PVA-PAA solution down to room tem
1. A method of making a PVA-hydrogel comprising: a) contacting an aqueous solution of poly(vinyl alcohol) (PVA) with an aqueous solution of poly(acrylic acid) (PAA) at a temperature above room temperature, thereby forming a homogenous PVA-PAA solution;b) cooling the PVA-PAA solution down to room temperature, thereby allowing formation of the PVA-hydrogel;c) cooling the PVA-hydrogel by freezing at a temperature below 0° C.; andd) thawing the PVA-hydrogel to a temperature above 0° C. 2. The method of claim 1, further comprising dehydrating the PVA-hydrogel to remove part or all of the water content. 3. The method of claim 2, wherein the dehydration is carried out at about 40° C., about 80° C., about 90° C., about 100° C., about 150° C., about 160° C., about 180° C., about 200° C., or above 200° C. for about an hour. 4. The method of claim 2, wherein the dehydration is carried out by heating the hydrogel in air or in inert atmosphere to an elevated temperature, wherein a heating rate ranges from about 0.01° C./minute to about 10° C./minute. 5. The method of claim 2, wherein the dehydrated hydrogel is re-hydrated by placing the dehydrated hydrogel: i) in water, saline solution, Ringer's solution, salinated water, buffer solution, and the like,ii) in a humid chamber, oriii) at room temperature or at an elevated temperature. 6. A PVA-hydrogel made by a process comprising: a) contacting an aqueous solution of poly(vinyl alcohol) (PVA) with an aqueous solution of poly(acrylic acid) (PAA) at a temperature above room temperature, thereby forming a homogenous PVA-PAA solution;b) cooling the PVA-PAA solution down to room temperature, thereby allowing formation of the PVA-hydrogel;c) cooling the PVA-hydrogel by freezing at a temperature below 0° C.; andd) thawing the PVA-hydrogel to a temperature above 0° C.,wherein the PVA-hydrogel comprises one or more hydrophilic polymers selected from the group consisting of: PVA-PAA copolymer, poly(ethylene oxide)(PEO)—PAA copolymer, poly(methacrylic acid) (PMAA), polyvinylpyrrolidone (PYP), hyaluronic acid (HA), and poly(allylamine hydrochloride) (PAH). 7. The PVA-hydrogel of claim 6, wherein the hydrogel comprises water and/or one or more other ingredients. 8. The PVA-hydrogel of claim 7, wherein the ingredient is PVA, PAA, PEG, and/or salt, proteoglycan, water soluble polymer, amino acid, alcohol, DMSO, or water soluble vitamin, and wherein the ingredient is partially or completely soluble in water. 9. The PVA-hydrogel of claim 7, wherein the ingredient is PEG, wherein the PEG is in a solution of water, ethanol, ethylene glycol, DMSO, or a suitable solvent. 10. The PVA-hydrogel of claim 7, wherein the ingredient is non-volatile. 11. The PVA-hydrogel of claim 7, wherein the ingredient is at least partially miscible in water. 12. The PVA-hydrogel of claim 7, wherein the ingredient is selected from the group consisting of PEG, salt, NaCl, KCl, CaCl2, vitamins, carboxylic acids, hydrocarbons, esters, and amino acids. 13. The PVA-hydrogel of claim 7, wherein the ingredient is PEG of different molecular weights or a blend of PEGs of different molecular weights. 14. The PVA-hydrogel of claim 7, wherein the ingredient is a water miscible polymer. 15. The PVA-hydrogel of claim 14, wherein the water miscible polymer is PEO, Pluronic, amino acids, proteoglycans, polyvinylpyrrolidone, polysaccharides, dermatin sulfate, keratin sulfate, chondroitin sulfate, or dextran sulfate. 16. A medical implant comprising a PVA-hydrogel according to claim 6. 17. The medical implant of claim 16 wherein the medical implant is an interpositional device. 18. The medical implant of claim 17, wherein the interpositional device a unispacer, wherein the unispacer is a free floating articular implant in a human joint. 19. The medical implant of claim 18, wherein the human joint is a knee, a hip, a shoulder, an elbow, or an upper or an extremity joint.
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