Plant HSP70 for Use in the Treatment of Food Allergy
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-038/16
A23L-001/29
A61K-036/48
출원번호
US-0984538
(2011-02-10)
공개번호
US-0303089
(2014-10-09)
국제출원번호
PCT/EP2011/051989
(2011-02-10)
§371/§102 date
20130903
(20130903)
발명자
/ 주소
Lax, Julia
Seifarth, Federico G.
출원인 / 주소
ALFA BIOGENE INTERNATIONAL B.V.
인용정보
피인용 횟수 :
0인용 특허 :
0
초록
Object of the invention is to provide a treatment for food allergy, in particular for peanut or milk allergy. This object was met by providing a plant Hsp70 or a hydrolysate thereof for use in the prophylactic or therapeutic treatment of a food allergy.
대표청구항▼
1. A method for the prophylactic or therapeutic treatment of a legume allergy comprising administering plant Hsp70 or a hydrolysate thereof to an individual. 2. The method of claim 1, wherein the plant is alfalfa. 3. (canceled) 4. (canceled) 5. The method of claim 1, wherein the legume allergy is pe
1. A method for the prophylactic or therapeutic treatment of a legume allergy comprising administering plant Hsp70 or a hydrolysate thereof to an individual. 2. The method of claim 1, wherein the plant is alfalfa. 3. (canceled) 4. (canceled) 5. The method of claim 1, wherein the legume allergy is peanut allergy. 6. (canceled) 7. The method of claim 1, wherein the treatment of the legume allergy comprises the treatment of an allergic reaction selected from the group consisting of anaphylaxis and dermatitis. 8. The method of claim 7, wherein the allergic reaction comprises anaphylaxis and wherein the legume allergy is a peanut allergy. 9. The method of claim 1, wherein the Hsp70 or hydrolysate thereof is administered mucosally. 10. The method of claim 1, wherein the Hsp70 or hydrolysate thereof is administered intranasally. 11. The method of claim 1, wherein the Hsp70 or hydrolysate thereof is administered by inhalation. 12. The method of claim 1, wherein the Hsp70 or hydrolysate thereof is administered enterally. 13. The method of claim 1, wherein the Hsp70 or hydrolysate thereof is administered parenterally. 14. The method of claim 1, wherein the Hsp70 is administered as a food product. 15. The method of claim 14, wherein the food product comprises an allergen capable of causing the legume allergy to be treated in a subject suffering said allergy. 16. The method of claim 14, wherein the Hsp70 is administered as a medical nutrition. 17. The method of claim 14, wherein the food product is selected from the group consisting of dairy products, dairy-substitute products, fruit products, soft-drinks, confectionery, cereal products and infant formulas. 18. The method of claim 1, wherein the Hsp70 is to be administered in a dosage of 1-250 μg. 19. The method of claim 1, wherein the Hsp70 or hydrolysate thereof is to be administered as part of a microparticle. 20. Food product comprising plant Hsp70 or hydrolysate thereof, which food product further comprises a carbohydrate fraction, a protein fraction and a lipid fraction, wherein the carbohydrate fraction provides 30 60 en %,the protein fraction provides 5-25 en %, andthe lipid fraction provides 25-55 en %, and wherein the food product comprises an allergan capable of causing a legume allergy. 21. (canceled) 22. Food product according to claim 20, wherein the food product is packaged in a unit dosage packaging and comprises a total dosage of Hsp70 of 1-250 μg. 23. Food product according to claim 20 comprising a microparticle comprising Hsp70 or hydrolysate thereof. 24. Food product according to claim 23, wherein the microparticle consists essentially of plant Hsp70 or hydrolysate thereof. 25. Food product according to claim 23, wherein the microparticle further comprises an encapsulating material. 26. Food product according to claim 25, wherein the microparticle comprises an inner nucleus comprising Hsp70 and an outer shell comprising the encapsulating material. 27. Aerosol suitable for oral or intranasal administration, comprising a plant Hsp70 or a hydrolysate thereof. 28. Nasal spray comprising a container holding a suspension of a plant Hsp70 or hydrolysate thereof and a nozzle for spraying the suspension. 29. Nasal spray according to claim 28, wherein the spray is an aerosol spray. 30. Inhaler comprising a container holding a plant Hsp70 or hydrolysate thereof and a mouthpiece for inhaling. 31. The method of claim 1, wherein the Hsp70 is to be administered in a dosage of 10-150 μg. 32. The method of claim 1, wherein the Hsp70 is to be administered in a dosage of 20-80 μg. 33. The method of claim 20 wherein the carbohydrate fraction provides 40-50 en %,the protein fraction provides 10-20 en %, andthe lipid fraction provides 35-45 en %. 34. Food product according to claim 20, wherein the food product is packaged in a unit dosage packaging and comprises a total dosage of Hsp70 of 10-150 μg. 35. Food product according to claim 20, wherein the food product is packaged in a unit dosage packaging and comprises a total dosage of Hsp70 of 20-80 μg.
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