Improved needle free injectors comprising of a energy sources, triggering mechanisms, impact members, and drug delivery pistons are disclosed. In one preferred embodiment, the triggering mechanism comprises a spool which seals an energy source comprised of compressed gas and a component for releasin
Improved needle free injectors comprising of a energy sources, triggering mechanisms, impact members, and drug delivery pistons are disclosed. In one preferred embodiment, the triggering mechanism comprises a spool which seals an energy source comprised of compressed gas and a component for releasing the spool to release the pressurized gas and urge a ram forward to force a drug containing formulation through a drug delivery orifice. The device may include a cap covering the orifice and safety mechanisms to prevent accidental delivery
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1. A needle free injector, comprising: a pressurized gas cylinder;a spool comprising a storage seal that maintains the gas cylinder in a pressurized state during storage;a means for releasing the spool in a manner which releases the pressurized gas into a chamber;a ram slidably positioned in the cha
1. A needle free injector, comprising: a pressurized gas cylinder;a spool comprising a storage seal that maintains the gas cylinder in a pressurized state during storage;a means for releasing the spool in a manner which releases the pressurized gas into a chamber;a ram slidably positioned in the chamber in a manner such that the ram is urged forward by released pressurized gas; anda drug container holding a liquid drug formulation in fluid connection with a drug delivery orifice;wherein the ram is forced to move by released pressurized gas, causing the liquid formulation to be delivered through the drug delivery orifice. 2. The needle free injector of claim 1, wherein the spool further comprises an additional seal that seals against loss of the pressurized gas after the gas has been released into the chamber. 3. The needle free injector of claim 2, wherein the spool is configured such that the pressurized gas holds the spool in a first position by a movable body which blocks motion of the spool prior to releasing the spool. 4. The needle free injector of claim 3, wherein the means for releasing the spool moves the movable body thereby exposing an end of the spool to a recess, into which recess the spool is moved by force applied by the pressurized gas. 5. The needle free injector of claim 4, wherein the movable body is moved by the act of pressing the drug delivery orifice against a surface. 6. The needle free injector of claim 5, wherein the surface is a desired injection site on human skin. 7. The needle free injector of claim 6, wherein the injector is configured such that upon releasing the spool a sub-cutaneous injection occurs forcing the liquid drug formulation out of the drug delivery orifice and through the human skin at the injection site. 8. The needle free injector of claim 7, wherein prior to releasing the spool the ram is separated by an air gap from a piston component; and wherein the piston component is in contact with the liquid drug formulation; andwherein the piston component seals the liquid drug in the drug container. 9. The needle free injector of claim 8, further comprising: a cap that covers the drug delivery orifice. 10. The needle free injector of claim 9, wherein the cap must be removed prior to releasing the spool. 11. The needle free injector of claim 10, wherein the cap is removed by an act chosen from: screw off;break off;click off; andpull off. 12. The needle free injector of claim 11, wherein the cap is comprised of a first set of threads and is removed by screwing it off. 13. The needle free injector of claim 12, wherein the cap comprises an additional feature that ensures that the act of removing the cap does not accidentally trigger the device. 14. The needle free injector of claim 13, further comprising: a case that substantially encloses the injector, the case comprising a mechanism that acts to bias the drug delivery orifice in a direction opposite that of the movement required to release the spool. 15. The needle free injector of claim 9, wherein removing the cap exposes a safety mechanism which requires actuation by an actuator prior to releasing the spool; wherein the actuator is comprised of a lever and the lever is comprised of a tip which is captured by the cap prior to removal of the cap; andwherein the safety mechanism comprises a blocking element that stops the movable body from moving when the drug deliver orifice is pressed against a surface, and further wherein actuating the safety mechanism via the actuator removes the blocking element. 16. (canceled) 17. (canceled) 18. The needle free injector of claim 8, wherein releasing the spool causes the pressurized gas to move the ram toward the piston and then striking the piston, causing an initial spike in liquid drug formulation pressure. 19. The needle free injector of claim 18, wherein the ram comprises a ram head characterized by a cross sectional area that is exposed to the pressurized gas when the spool is released; and wherein the area of the ram head, the pressure of the pressurized gas, the area of the drug delivery orifice, and the length of the air gap separating the ram from the piston component are selected such that the initial spike in pressure elects liquid drug formulation out of the orifice in a manner that forms a hole into the sub-cutaneous region below the skin. 20. (canceled) 21. The needle free injector of claim 19, wherein the length of the gap is maintained during storage of the device by a holding element that holds the ram in place prior to releasing the spool and releases the ram upon releasing the spool; and wherein the holding element releases the ram by a mechanism chosen from:shearing;deforming;overcoming friction between the ram and the holding element;being actuated by an actuator; anda combination thereof. 22. (canceled) 23. The needle free injector of claim 8, wherein the drug container is a single component which comprises the drug delivery orifice; and wherein the container is comprised of borosilicate glass. 24. (canceled) 25. The needle free injector of claim 5, wherein the drug delivery container comprises a nozzle component comprising the drug delivery orifice, and a separate borosilicate glass component, wherein the borosilicate glass component is a circular tube; wherein said nozzle component is held sufficiently rigidly to the glass component that no leakage of formulation occurs during storage; andfurther wherein said nozzle component is held sufficiently rigidly to the glass component that no leakage of formulation occurs when the injector is triggered. 26. The needle free injector of claim 12, wherein the cap comprises an elastomeric sealing element that seals the drug delivery orifice; and wherein the cap further comprises: a rotating element that eliminates strain and concomitant leakage from the elastomeric sealing element that would otherwise arise when the cap is screwed onto the device. 27. (canceled) 28. (canceled) 29. The needle free injector of claim 1, wherein the container is prefilled with 0.6 mL to about 1.6 mL of liquid drug formulation. 30. The needle free injector of claim 1, wherein the injector is prefilled with about 1.0 ml of liquid drug formulation. 31. The needle free injector of claim 14, wherein said additional feature comprises a second set of threads; and wherein said mechanism is a set of threads that engage with said second set of threads. 32. The needle free injector of claim 31, wherein said first set of threads engage a corresponding set of threads, said corresponding set of threads are characterized by a property chosen from: being part of the drug container;being attached to the drug container;being attached to a component of the needle free injector that is held rigidly at a fixed distance to the drug container. 33. (canceled) 34. A needle free injector, comprising: a drug capsule containing a liquid drug formulation;an orifice in the container, the orifice leading to the liquid drug formulation;a first gas reservoir containing a first pressurized gas at a first pressure;the first pressurized gas in contact with and urging forward a drug dispensing member;wherein movement of the drug dispensing member is prevented by a trigger mechanism;a second gas reservoir containing a second pressurized gas at a second pressure; andwherein said dispensing member is not urged forward by said second pressurized gas until after it is released by said trigger mechanism.wherein said first pressure is greater than said second pressure.wherein said first gas reservoir is axially aligned with said dispensing member, and said second gas reservoir is displaced radially from said dispensing member.further wherein the injector is configured such that after the drug dispensing member is released by the trigger mechanism, the drug dispensing member travels forward, exposing a gas flow path that allows the second pressurized gas to urge the drug dispensing member forward. 35-42. (canceled) 43. A needle free injector, comprising: a drug capsule containing a liquid drug;an orifice;a source of energy;a trigger mechanism comprising a ball bearing;wherein when said trigger mechanism triggers the needle free injector, said source of energy forces the majority of said liquid drug through said at least one orifice.wherein said source of energy comprises a spring chosen from:a mechanical coil spring;a Belleville washer stack; anda compressed gas spring. 44-50. (canceled)
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