Aptamer-based Sensors, Implantable Devices and Detection System
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61B-005/00
A61B-005/07
A61B-005/145
A61B-005/1473
A61B-005/1459
출원번호
US-0669424
(2015-03-26)
공개번호
US-0278638
(2016-09-29)
발명자
/ 주소
SCHWARTZ, Jerrod Joseph
THOMPSON, Jason Donald
BAJAJ, Vikram Singh
출원인 / 주소
Google Inc.
인용정보
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초록▼
A system for measuring and/or monitoring an analyte present in interstitial fluid in skin is provided. The system includes a substrate that may be implanted into the skin and a reader device. The substrate includes a sensor comprising aptamer conjugates and is configured to obtain one or more measur
A system for measuring and/or monitoring an analyte present in interstitial fluid in skin is provided. The system includes a substrate that may be implanted into the skin and a reader device. The substrate includes a sensor comprising aptamer conjugates and is configured to obtain one or more measurements related to at least one analyte in interstitial fluid. The reader device is configured to detect the analyte in interstitial fluid via interaction with the substrate.
대표청구항▼
1. A system, comprising: a substrate comprising a sensor, the sensor comprising aptamer conjugates, wherein the sensor is configured to obtain one or more measurements related to at least one analyte in interstitial fluid, and wherein the substrate is configured for implantation into skin; anda read
1. A system, comprising: a substrate comprising a sensor, the sensor comprising aptamer conjugates, wherein the sensor is configured to obtain one or more measurements related to at least one analyte in interstitial fluid, and wherein the substrate is configured for implantation into skin; anda reader device, wherein the reader device is configured to detect the analyte in interstitial fluid via interaction with the substrate. 2. The system of claim 1, wherein the aptamer conjugate comprises a labeled aptamer conjugated to a polymer. 3. The system of claim 2, wherein the labeled aptamer possesses or comes to possess a detectable signal. 4. The system of claim 1, wherein the sensor is configured to obtain one or more measurements related to multiple analytes. 5. The system of claim 1, wherein the substrate further comprises an antenna, and wherein the reader device is configured to detect the analyte based on data communicated via the antenna. 6. The system of claim 5, wherein the data communicated via the antenna is indicative of the one or more measurements. 7. The system of claim 6, wherein the sensor is an electrochemical sensor comprising a working electrode and a reference electrode. 8. The system of claim 1, wherein the substrate comprises a component configured to undergo an optically-detectable change related to the analyte, wherein the optically-detectable change comprises a change in at least one of optical absorption, reflectivity, or fluorescence. 9. The system of claim 8, wherein the reader device is configured to detect the optically-detectable change. 10. The system of claim 9, wherein the optically-detectable change is optical absorption, reflectivity, or fluorescence. 11. The system of claim 9, wherein the reader device comprises: a light source configured to direct light toward the substrate; anda photodetector configured to detect light from the substrate. 12. The system of claim 1, wherein the substrate comprises: bio-interactive electronics, wherein the bio-interactive electronics are selectively sensitive to an analyte, and wherein the bio-interactive electronics are embedded in a polymeric material. 13. The system of claim 12, wherein the analyte is an ion, andthe bio-interactive electronics comprise a sensitizing layer comprising an ionophore. 14. The system of claim 1, wherein the reader further comprises a first antenna; andthe substrate further comprises a second antenna, whereinthe reader is configured to provide radio frequency (RF) power to the substrate via the first antenna,the sensor is configured to harvest the RF power, measure an analyte concentration level, and communicate a sensor reading back to the reader via the second antenna. 15. The system of claim 1, wherein the reader is a wearable device. 16. A method, comprising: receiving, by a substrate, a signal from a reader device, wherein the substrate comprises a sensor, the sensor comprising aptamer conjugates, and wherein the substrate is implanted into skin;performing, by the sensor, in response to the signal, a measurement related to at least one analyte in interstitial fluid; andcommunicating, by the substrate, data indicative of the measurement to the reader device. 17. The method of claim 16, wherein the signal is a radio frequency (RF) signal, and wherein the substrate comprises an antenna. 18. The method of claim 16, wherein the signal is an optical signal, and wherein the data indicative of the measurement comprises at least one of optical absorption, reflectivity, or fluorescence. 19. A method, comprising: transmitting, by a reader device, a signal to a substrate implanted into skin, the substrate comprising a sensor, the sensor comprising aptamer conjugates, wherein the sensor is configured to obtain one or more measurements related to at least one analyte in interstitial fluid; andreceiving, by the reader device, a responsive signal from the substrate, wherein the responsive signal indicates the one or more measurements related to the analyte in the interstitial fluid. 20. The method of claim 19, wherein the substrate further comprises an antenna, wherein the signal and the responsive signal are radio frequency (RF) signals, and wherein the responsive signal comprises data indicative of the one or more measurements related to the analyte obtained by the sensor. 21. The method of claim 19, wherein the signal and the responsive signal are optical signals, wherein the substrate comprises a component configured to undergo an optically-detectable change related to the analyte, wherein the optically-detectable change comprises a change in at least one of optical absorption, reflectivity, or fluorescence, and wherein the responsive signal indicates the concentration of an analyte in interstitial fluid.
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