METHOD FOR TREATING INTERVERTEBRAL DISC DEGENERATION
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IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-031/765
A61K-009/00
출원번호
US-0148488
(2016-05-06)
공개번호
US-0324888
(2016-11-10)
발명자
/ 주소
Nicoll, Steven B.
Varma, Devika
출원인 / 주소
Nicoll, Steven B.
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
An injectable carboxymethylcellulose (CMC) and methylcellulose (MC) hydrogel derived from the plant-based polysaccharide, cellulose, is provided which gels in situ and repairs the intervertebral disc in the spinal column or other cartilaginous tissues. One specific application is for replacement of
An injectable carboxymethylcellulose (CMC) and methylcellulose (MC) hydrogel derived from the plant-based polysaccharide, cellulose, is provided which gels in situ and repairs the intervertebral disc in the spinal column or other cartilaginous tissues. One specific application is for replacement of the nucleus pulposus (NP), the central gelatinous region of the intervertebral disc, following injury or degeneration.
대표청구항▼
1. A method for providing therapeutic benefit to a patient, the method comprising: injecting a composition of matter between a first bone and a second bone of a patient, the composition of matter comprising methacrylated carboxymethylcellulose (CMC) and methacrylated methylcellulose (MC), wherein th
1. A method for providing therapeutic benefit to a patient, the method comprising: injecting a composition of matter between a first bone and a second bone of a patient, the composition of matter comprising methacrylated carboxymethylcellulose (CMC) and methacrylated methylcellulose (MC), wherein the patient has a body temperature of at least 33° C.;permitting the composition of matter to undergo thermal polymerization at the body temperature of the patient, thereby forming a hydrogel between the first bone and the second bone. 2. The method as recited in claim 1, wherein the methacrylated methylcellulose is a mix of a first methacrylated methylcellulose with a first molecular weight below about 20 kDa and a second methacrylated methylcellulose with a second molecular weight above about 30 kDa, the mix being at less than 8% (w/v) concentration. 3. The method as recited in claim 1, wherein the methacrylated methylcellulose is a mix of a first methacrylated methylcellulose with a first molecular weight below about 20 kDa and a second methacrylated methylcellulose with a second molecular weight above about 30 kDa, the mix being at less than 8% (w/v) concentration, the first methacrylated methylcellulose and the second methacrylated methylcellulose being in about a 1:1 (w/w) ratio. 4. The method as recited in claim 1, wherein the methacrylated methylcellulose is a mix of a first methacrylated methylcellulose with a first molecular weight below about 20 kDa and a second methacrylated methylcellulose with a second molecular weight above about 30 kDa and below about 50 kDa, the mix being at less than 8% (w/v) concentration. 5. The method as recited in claim 1, wherein the methacrylated methylcellulose is a mix of a 14 kDa methacrylated methylcellulose and a 41 kDa methacrylated methylcellulose at about 3% (w/v) concentration. 6. The method as recited in claim 1, wherein the methacrylated carboxymethylcellulose has a molecular weight between about 80 kDa and about 100 kDa. 7. The method as recited in claim 1, wherein the methacrylated carboxymethylcellulose has a molecular weight between about 80 kDa and about 100 kDa and is less than 8% (w/v) concentration. 8. The method as recited in claim 1, wherein the methacrylated carboxymethylcellulose has a molecular weight of 90 kDa at about 3% (w/v) concentration. 9. The method as recited in claim 1, wherein the methacrylated methylcellulose is modified with methacrylate groups at a modification percentage of about 3-10% and the methacrylated carboxymethylcellulose is modified with methacrylate groups at a modification percentage of about 8-25%. 10. A method for providing therapeutic benefit to a patient experiencing intervertebral disc degeneration, the method comprising: removing nucleus pulposus (NP) tissue from between a first vertebra and a second vertebra of a patient;injecting a composition of matter between the first vertebra and the second vertebra of the patient, the composition of matter comprising methacrylated carboxymethylcellulose (CMC) and methacrylated methylcellulose (MC), wherein the methacrylated methylcellulose is a mix of a first methacrylated methylcellulose with a first molecular weight below about 20 kDa and a second methacrylated methylcellulose with a second molecular weight above about 30 kDa, the mix being at less than 8% (w/v) concentration, wherein the patient has a body temperature of at least 33° C.;permitting the composition of matter to undergo thermal gelation at the body temperature of the patient, thereby forming a hydrogel between the first vertebra and the second vertebra. 11. The method as recited in claim 10, wherein the hydrogel has an equilibrium Young's modulus (Er) of about 5 kPa. 12. The method as recited in claim 10, wherein the composition of matter includes a redox initiator system. 13. The method as recited in claim 12, wherein the redox initiator system is selected from the group consisting of ammonium persulfate, tetramethyl-ethylenediamine and combinations thereof. 14. The method as recited in claim 13, wherein the redox initiator system is present in a concentration of about 20 mM. 15. A method for providing therapeutic benefit to a patient experiencing intervertebral disc degeneration, the method comprising: removing nucleus pulposus (NP) tissue from between a first vertebra and a second vertebra of a patient;injecting a composition of matter between the first vertebra and the second vertebra of the patient, the composition of matter comprising a redox initiator system, methacrylated carboxymethylcellulose (CMC) and methacrylated methylcellulose (MC), wherein the methacrylated methylcellulose is a mix of a first methacrylated methylcellulose with a first molecular weight below about 20 kDa and a second methacrylated methylcellulose with a second molecular weight above about 30 kDa, wherein the patient has a body temperature of at least 33° C.;permitting the composition of matter to undergo thermal gelation and redox polymerization at the body temperature of the patient, thereby forming a hydrogel between the first vertebra and the second vertebra. 16. The method as recited in claim 15, wherein the methacrylated carboxymethylcellulose has a molecular weight between about 80 kDa and about 100 kDa. 17. The method as recited in claim 15, wherein the methacrylated carboxymethylcellulose has a molecular weight between about 80 kDa and about 100 kDa and is less than 8% (w/v) concentration.
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