Devices, systems and methods for needle free injection include a multi-use needle-free injection device comprising reversibly connected proximate and distal sections, wherein the proximate section comprises a power supply, actuator, circuitry and a housing, and the distal section comprises a disposa
Devices, systems and methods for needle free injection include a multi-use needle-free injection device comprising reversibly connected proximate and distal sections, wherein the proximate section comprises a power supply, actuator, circuitry and a housing, and the distal section comprises a disposable nozzle tip prefilled with an injectate, a chemical energetic device, and a dual seal piston barrier between the energetic device and the injectate, wherein the proximate and distal sections and their components are operably linked and configured for single-hand injecting of the injectate.
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1. A needle-free injection delivery system comprising: a distal section having a disposable nozzle assembly that comprises: a chemical igniter sealed inside a nozzle body,an injectate stored inside a nozzle tip, and connected to the igniter, anda plunger, forming a sealed barrier between the injecta
1. A needle-free injection delivery system comprising: a distal section having a disposable nozzle assembly that comprises: a chemical igniter sealed inside a nozzle body,an injectate stored inside a nozzle tip, and connected to the igniter, anda plunger, forming a sealed barrier between the injectate and the chemical igniter, the plunger configured to introduce the injectate into a subject upon activation of the chemical igniter; anda proximal section, removably coupled to the distal section, and comprising a housing having therein electrical circuitry configured to control the activation of the chemical igniter. 2. The system of claim 1, wherein the chemical igniter is a chemical energetic device. 3. The system of claim 1, wherein the chemical igniter comprises an energetic material selected from a list comprising zirconium potassium perchlorate (ZZP), boron-potassium nitrate (BPN or BKNO3), aluminum-potassium perchlorate and titanium-aluminum-potassium perchlorate, zirconium hydride—potassium perchlorate (ZHPP), titanium hydride potassium perchlorate (THPP), titanium-boron, nickel-aluminum, palladium-aluminum, cis-bis-(5-nitrotetrazolato)tetraminecobalt(III) perchlorate (BNCP), lead azide, Hexamethylene triperoxide diamine (HMTD), tetrazene explosive, lead mononitro-resorcinates, lead dinitro-resorcinates, and lead trinitro-resorcinates. 4. The system of claim 1, wherein the nozzle assembly further comprises an expansion chamber between the chemical igniter and the plunger, the expansion chamber being configured to control a depth of penetration of the injectant inside the subject. 5. The system of claim 1, wherein at least one of the chemical igniter and expansion chamber is configured to generate a pressure in a range between 3000 and 6000 psi. 6. The system of claim 1, wherein the nozzle assembly further comprises a sleeve that circumscribes at least a portion of the nozzle body. 7. The system of claim 1, wherein the nozzle assembly is coupled to an integration part attached to the proximal section using a plug and lock ring. 8. The system of claim 1, wherein the circuitry further comprises an actuator operated by a user that is configured to activate the chemical igniter to generate a pressure gradient inside the nozzle assembly sufficient to translocate the plunger inside a bore and introduce the injectate into the subject. 9. The system of claim 1, wherein the circuitry further comprises a charging switch operated by a user and configured to allow or prevent the activation of the chemical igniter. 10. The system of claim 1, wherein the nozzle tip further comprises at least one opening through which the injectate traverses, the at least one opening configured to generate a microjet that pierces a skin of the subject. 11. The system of claim 10, wherein the at least one opening has a diameter in a range between 0.005″ to 0.020″. 12. The system of claim 10, wherein the at least one opening extends radially outward. 13. The system of claim 10, wherein the injectant comprises at least one of a drug, a medicament, a vaccine, a dye, a contrast agent, and nanoparticle sensors. 14. The system of claim 1, wherein the nozzle tip further comprises a non-hypodermic pin prick configured to penetrate a membrane covering the skin of the subject. 15. The system of claim 14, wherein the non-hypodermic pin prick has an orifice diameter in a range between 0.005″ to 0.020″, and a length and width in a range between 0.25 mm to 3 mm. 16. The system of claim 1, wherein proximate section further comprises connector components configured to make an electrical connection and a mechanical connection to the distal section. 17. The system of claim 1, wherein the system further comprises a kit including a set of disposable nozzle tips prefilled with the injectate. 18. A method for operating a needle-free injection delivery system comprising a chemical igniter housed inside a nozzle body of a disposable nozzle assembly, an injectate connected to the chemical igniter and stored inside a nozzle tip of the disposable nozzle assembly, and a plunger forming a seal barrier between the chemical igniter and injectate, the method comprising: pressing the nozzle tip against a skin of a subject;operating a charging switch to allow activation of the chemical igniter; andoperating an actuator to activate the chemical igniter. 19. The method of claim 18, wherein the chemical igniter is configured to generate a pressure gradient inside the disposable nozzle assembly sufficient to translocate the plunger and introduce the injectate into the skin of the subject. 20. The method of claim 19, wherein the pressure gradient includes pressures in a range between 3000 and 6000 psi.
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