Provided herein are fullerene compositions, and methods of preparing fullerene compositions. More particularly, the fullerene compositions include a fullerene-polymer complex having a fullerene and a non- conjugated hydrophilic or amphiphilic polymer. The non- conjugated polymer is substituted with
Provided herein are fullerene compositions, and methods of preparing fullerene compositions. More particularly, the fullerene compositions include a fullerene-polymer complex having a fullerene and a non- conjugated hydrophilic or amphiphilic polymer. The non- conjugated polymer is substituted with a substituent having a functional group capable of forming intermolecular interactions with the fullerene via pi-stacking.
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1. A composition comprising a fullerene-polymer complex comprising one or more fullerenes and a non-conjugated hydrophilic or amphiphilic polymer, said non-conjugated polymer being substituted with at least one substituent comprising a functional group comprising a carbon-carbon pi-bond which intera
1. A composition comprising a fullerene-polymer complex comprising one or more fullerenes and a non-conjugated hydrophilic or amphiphilic polymer, said non-conjugated polymer being substituted with at least one substituent comprising a functional group comprising a carbon-carbon pi-bond which interacts with said one or more fullerenes via pi-stacking. 2. The composition according to claim 1, wherein said functional group is selected from the group consisting of allyl, propargyl, phenyl, naphthyl, pyrenyl, vinyl, ethynyl, benzyl, anthryl, indolyl, imidazolyl, thienyl, pyrazinyl, pyrimidinyl, piridazinyl, and triazolyl. 3. The composition according to claim 1, wherein said non-conjugated polymer is a linear polymer wherein at least one chain end of said linear polymer is provided with said functional group. 4. The composition according to claim 1, wherein said non-conjugated polymer is selected from the group consisting of polyvinylpyrrolidone (PVP), poly(ethylene glycol) (PEG), a polymer produced from a cyclic imino ether, polyvinyl alcohol (PVA), a dextran, polyglutamic acid (PGA), a poly(oligoethylene glycol acrylate) (POEGA), a poly(oligoethylene glycol methacrylate) (POEGMA), poly[N-(2-hydroxypropyl)methacrylamide (PHPMA), and copolymers thereof. 5. The composition according claim 1 wherein said non-conjugated polymer further comprises an amide bond. 6. The composition according to claim 1, wherein said fullerene-polymer complex is provided as particles having an average size between 25 nm and 100 nm as measured via dynamic light scattering. 7. The composition according to claim 1 wherein said fullerene-polymer complex is suspended in an aqueous solvent, and wherein said composition comprises at least 1 wt % of said one or more fullerenes. 8. The composition according to claim 1, wherein said one or more fullerenes comprise at least 90 wt % C60. 9. A medicament comprising the composition according to claim 1, for use in medicine. 10. A method for the treatment of an oxidative damage-related diseases or disorders comprising administering a composition according to claim 1 to a patient in need thereof. 11. An antioxidant composition comprising a composition according to claim 1. 12. A method for the preparation of the composition according to claim 1, comprising: (a) providing one or more fullerenes and a non-conjugated hydrophilic or amphiphilic polymer, said non-conjugated polymer being substituted with at least one substituent comprising a functional group comprising a carbon-carbon pi-bond capable of interacting with said fullerene via pi-stacking; and(b) mechanochemically treating said fullerene and said non-conjugated polymer, thereby obtaining a fullerene-polymer complex. 13. The method according to claim 12, wherein step (b) comprises milling said fullerene and said non-conjugated polymer. 14. The method according to claim 12, wherein said functional group is selected from the list consisting of allyl, propargyl, phenyl, naphthyl, and pyrenyl. 15. The method according to claim 12, wherein step (b) is performed in the absence of solvents. 16. A method for increasing the solubility of fullerenes in water, comprising forming a complex between a fullerene and a non-conjugated polymer, wherein said non-conjugated polymer is substituted with at least one substituent comprising a functional group comprising a carbon-carbon pi-bond capable of interacting with said fullerene via pi-stacking. 17. The method of claim 10, wherein the oxidative damage-related disease or disorder is selected from the group consisting of Parkinson's disease, Alzheimer's disease, cardiovascular diseases, and cancer. 18. The method of claim 13, wherein the milling is performed using High Speed Vibration Milling.
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