The present disclosure discloses a boron neutron capture therapy system comprising: a boron neutron capture therapy device and an α-amino acid-like boron trifluoride compound having a structure shown as formula (I) below: Wherein: R is selected from hydrogen, methyl, isopropyl, 1-methylpropyl, 2-me
The present disclosure discloses a boron neutron capture therapy system comprising: a boron neutron capture therapy device and an α-amino acid-like boron trifluoride compound having a structure shown as formula (I) below: Wherein: R is selected from hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, hydroxymethyl, 1-hydroxyethyl, benzyl or hydroxybenzyl; M is H or metal atom. The energy generated from the action of the neutron beam generated by the boron neutron capture therapy device on the α-amino acid-like boron trifluoride compound destroys tumor cell DNA. In another aspect, the present disclosure discloses a use of an α-amino acid-like boron trifluoride compound in the preparation of a medicament for tumor therapy.
대표청구항▼
1. A boron neutron capture therapy system comprising: a boron neutron capture therapy device; andan α-amino acid-like boron trifluoride compound having a structure shown as formula (I) below: wherein, R represents hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, hydroxymethyl, 1-hydroxye
1. A boron neutron capture therapy system comprising: a boron neutron capture therapy device; andan α-amino acid-like boron trifluoride compound having a structure shown as formula (I) below: wherein, R represents hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, hydroxymethyl, 1-hydroxyethyl, benzyl or hydroxybenzyl;M represents H or metal atom;the energy generated from the action of the neutron beam generated by the boron neutron capture therapy device on the α-amino acid-like boron trifluoride compound destroys tumor cell DNA. 2. The boron neutron capture therapy system according to claim 1, wherein the boron neutron capture therapy device comprises a neutron generator and a beam shaping assembly for adjusting the neutron beam energy spectrum generated by the neutron generator to an epithermal neutron energy zone. 3. The boron neutron capture therapy system according to claim 2, wherein the beam shaping assembly comprises: a moderator adjacent to the neutron generator, wherein the moderator moderates neutrons generated from the neutron generator to an epithermal neutron energy zone,a reflector surrounding the moderator, wherein the reflector leads the deflected neutrons back to increase the intensity of an epithermal neutron beam,a thermal neutron absorber adjacent to the moderator, wherein the thermal neutron absorber absorbs thermal neutrons to avoid overdosing in superficial normal tissues during therapy, anda radiation shield arranged in the beam shaping assembly, wherein the radiation shield shields leaking neutrons and photons to reduce dose of the normal tissue not exposed to irradiation. 4. The boron neutron capture therapy system according to claim 3, wherein the boron neutron capture therapy device further comprises a collimator disposed at the beam outlet for converging the epithermal neutrons. 5. The boron neutron capture therapy system according to claim 1, wherein M represents potassium or sodium. 6. The boron neutron capture therapy system according to claim 1, wherein the element B is 10B. 7. The boron neutron capture therapy system according to claim 6, wherein the purity of 10B in the α-amino acid-like boron trifluoride compound is ≥95%. 8. The boron neutron capture therapy system according to claim 1, wherein at least one element F in the α-amino acid-like boron trifluoride compound is 18F.
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