IPC분류정보
국가/구분 |
United States(US) Patent
공개
|
국제특허분류(IPC7판) |
|
출원번호 |
16486075
(2018-02-15)
|
공개번호 |
20200001118
(2020-01-02)
|
국제출원번호 |
PCT/US18/18323
(2018-02-15)
|
발명자
/ 주소 |
- Snider, III, James William
- Regine, William F.
- Zhu, Mingyao
- Langen, Katja
|
출원인 / 주소 |
- Snider, III, James William
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
0 |
초록
▼
Techniques for particle beam therapy include receiving a target region inside a subject for particle therapy, a minimum dose inside the target region, and a maximum dose inside the subject but outside target region. Multiple beam axis angles are determined, each involving a grantry angle and a couch
Techniques for particle beam therapy include receiving a target region inside a subject for particle therapy, a minimum dose inside the target region, and a maximum dose inside the subject but outside target region. Multiple beam axis angles are determined, each involving a grantry angle and a couch position. Multiple spots within the target region are determined. For each beam axis angle a pristine particle scan beam (not coaxial with any other particle scan beam) is determined such that a Bragg Peak is directed to a spot, and repeated until every spot is subjected to a Bragg Peak or an intersection of two or more such pristine scan beams. Output data indicating the pristine beamlets is stored for operation of a particle beam therapy apparatus.
대표청구항
▼
1. A method for beam therapy comprising: receiving first data indicating a target region inside a subject for particle therapy, a minimum dose inside the target region, and a maximum dose inside the subject but outside target region;determining a plurality of beam axis angles, each beam axis angle c
1. A method for beam therapy comprising: receiving first data indicating a target region inside a subject for particle therapy, a minimum dose inside the target region, and a maximum dose inside the subject but outside target region;determining a plurality of beam axis angles, each beam axis angle comprising a gantry angle and a couch position;determining a plurality of spots within the target region;determining for each beam axis angle a pristine beamlet with corresponding scan beam angle and particle initial energy to direct a Bragg Peak at a spot of the plurality of spots;repeating the previous step until every spot of the plurality of spots is subjected to a Bragg peak or an intersection of two or more pristine beamlets; andcausing output data indicating the pristine beamlets to be stored for operation of a particle beam therapy apparatus. 2. The method of claim 1, wherein: the method further comprises determining on a processor spatial distribution of delivered dose inside the subject accumulated from all of the plurality of pristine beamlets, anddetermining on the processor whether the spatial distribution of delivered dose satisfies the first data; andcausing output data to be stored further comprises causing output data to be stored only if it is determined that the spatial distribution of delivered dose satisfies the first data. 3. The method of claim 1, wherein spacing of the plurality of spots are based at least in part on a target spacing distance for a type of tissue in the target region. 4. The method of claim 3, wherein the plurality of spots are spaced apart from each other by the target spacing distance. 5. The method of claim 3, wherein the plurality of spots are spaced apart from an edge of the target region by about the target spacing distance. 6. The method of claim 3, wherein the target spacing distance is about 1 centimeter (cm) to about 3 cm. 7. The method of claim 1, wherein no two scan beams for one beam axis angle are closer, inside the subject but outside the target region, than a scan separation distance based at least in part on a sparing distance. 8. The method of claim 7, wherein the scan separation distance is at least twice the sparing distance. 9. The method of claim 7, wherein the sparing distance is about a 1 centimeter to about 3 cm. 10. The method of claim 1, wherein determining the plurality of spots within the target region further comprises determining the plurality of spots within the target region such that no two spots are coaxial in a beam's eye view along any of the plurality of beam axis angles. 11. The method of claim 10, wherein determining for each beam axis angle a pristine beamlet further comprises determining a scan beam, having a corresponding scan beam angle and particle initial energy, for every spot separated by at least the sparing distance in a beam's eye view for the beam axis angle. 12. The method of claim 11, wherein determining the plurality of spots within the target region further comprises determining a grid of spots separated by a distance based at least in part on the target spacing distance, wherein the grid is rotated such that each spot is separated in the beam's eye view for the beam axis angle. 13. The method of claim 1, wherein determining the plurality of spots within the target region further comprises determining a grid of spots rotated relative to each beam axis angle such that each spot is separated in the beam's eye view for the beam axis angle by at least the sparing distance. 14. The method of claim 13, wherein determining for each beam axis angle a pristine beamlet further comprises determining a scan beam, having a corresponding scan beam angle and particle initial energy, for every spot in a beam's eye view for the beam axis angle. 15. The method of claim 2, wherein a portion inside the target region of the spatial distribution of delivered dose is heterogeneous with a maximum and minimum in delivered dose which differ by a factor in a range from about 2 to about 8. 16. The method of claim 15, wherein the minimum dose inside the target region is about 10 gray (Gy). 17. A non-transitory computer-readable medium carrying one or more sequences of instructions, wherein execution of the one or more sequences of instructions by one or more processors causes the one or more processors to: receive first data indicating a target region inside a subject for particle therapy, a minimum dose inside the target region, and a maximum dose inside the subject but outside target region;determine a plurality of beam axis angles, each beam axis angle comprising a gantry angle and a couch position;determine a plurality of spots within the target region;determine for each beam axis angle a pristine beamlet with corresponding scan beam angle and particle initial energy to direct a Bragg Peak at a spot of the plurality of spots;repeat the previous step until every spot of the plurality of spots is subjected to a Bragg peak or an intersection of two or more pristine beamlets; andcause output data indicating the pristine beamlets to be stored for operation of a particle beam therapy apparatus. 18. A system comprising: a particle beam therapy apparatus;at least one processor; andat least one memory including one or more sequences of instructions,the at least one memory and the one or more sequences of instructions configured to, with the at least one processor, cause the system to perform at least; receiving first data indicating a target region inside a subject for particle therapy, a minimum dose inside the target region, and a maximum dose inside the subject but outside target region;determining a plurality of beam axis angles, each beam axis angle comprising a gantry angle and a couch position;determining a plurality of spots within the target region;determining for each beam axis angle a pristine beamlet with corresponding scan beam angle and particle initial energy to direct a Bragg Peak at a spot of the plurality of spots;repeating the previous step until every spot of the plurality of spots is subjected to a Bragg peak or an intersection of two or more pristine beamlets; andcausing output data indicating the pristine beamlets to be stored for operation of the particle beam therapy apparatus.
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