NEAR INFRARED ABSORBING DYE-BASED COMPOSITE PARTICLES EXHIBITING PHOTOTHERMAL EFFECT, METHOD FOR MANUFACTURING THE SAME, AND USE THEREOF
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-041/00
C09B-023/08
C09B-067/46
C09B-067/02
C09B-067/54
A61N-005/06
출원번호
16395236
(2019-04-26)
공개번호
20200016269
(2020-01-16)
우선권정보
KR-10-2018-0080494 (2018-07-11)
발명자
/ 주소
KIM, Sehoon
KIM, Youngsun
JEONG, Keunsoo
KIM, Gayoung
출원인 / 주소
KIM, Sehoon
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
The present invention relates to near-infrared-absorbing dye-based composite particles which exhibit a photothermal effect and/or photoacoustic signal upon photoirradiation, a preparation method thereof, and a use thereof. The near-infrared-absorbing composite particles comprise: a water-insoluble s
The present invention relates to near-infrared-absorbing dye-based composite particles which exhibit a photothermal effect and/or photoacoustic signal upon photoirradiation, a preparation method thereof, and a use thereof. The near-infrared-absorbing composite particles comprise: a water-insoluble salt of a near-infrared-absorbing dye, which comprises anions of the near-infrared-absorbing dye and metal cations capable of forming a precipitation product with the anions of the near-infrared-absorbing dye; and particles of a polymeric surfactant, in which a water-insoluble salt of the near-infrared-absorbing dye is supported in the hydrophobic part of the polymeric surfactant.
대표청구항▼
1. A method for preparing a near-infrared-absorbing dye-based composite particle, comprising: a first step, in which an ionizable near-infrared-absorbing dye, that is in a state dissolved in an aqueous medium, undergoes a precipitation reaction with an ionic compound capable of providing a metal cat
1. A method for preparing a near-infrared-absorbing dye-based composite particle, comprising: a first step, in which an ionizable near-infrared-absorbing dye, that is in a state dissolved in an aqueous medium, undergoes a precipitation reaction with an ionic compound capable of providing a metal cation that is able to form a precipitation product with an anion of the near-infrared-absorbing dye, and forms a water-insoluble salt of the near-infrared-absorbing dye; anda second step, in which a dispersion in which the water-insoluble salt of the near-infrared-absorbing dye is dispersed is mixed with an aqueous solution comprising a polymeric surfactant and then supports the water-insoluble salt of the near-infrared-absorbing dye in a particle of the polymeric surfactant. 2. The method of claim 1, wherein the second step not only supports the water-insoluble salt of the near-infrared-absorbing dye in the particle of the polymeric surfactant, but also further supports, in the particle of the polymeric surfactant, an additive selected from the group consisting of a therapeutic agent, a diagnostic agent, and a contrast agent. 3. The method of claim 1, wherein, in the first step, the metal cation that is able to form a precipitation product with an anion of a near-infrared-absorbing dye is an iron ion. 4. The method of claim 1, wherein, in the first step, the ionizable near-infrared-absorbing dye is at least one selected from the group consisting of a hydrophilic cyanine dye comprising a sulfonate group, indocyanine green (ICG), cyanine 5.5 (Cy5.5), and cyanine 7 (Cy7). 5. The method of claim 1, wherein the near-infrared-absorbing dye-based composite particle is a near-infrared-absorbing composite particle that exhibits a photothermal effect or photoacoustic signal upon photoirradiation. 6. The method of claim 1, wherein the near-infrared-absorbing dye-based composite particle being prepared exhibits inhibition of non-specific aggregation, inhibition of absorption into serum proteins, inhibition of photodegradation, or a combination thereof, compared to the ionizable near-infrared-absorbing dye of the first step. 7. A near-infrared-absorbing composite particle comprising: a water-insoluble salt of a near-infrared-absorbing dye, which comprises: an anion of the near-infrared-absorbing dye; anda metal cation capable of forming a precipitation product with the anion of the near-infrared-absorbing dye; anda particle of a polymeric surfactant, in which a water-insoluble salt of the near-infrared-absorbing dye is supported in the hydrophobic part of the polymeric surfactant,wherein the near-infrared-absorbing composite particle exhibits a photothermal effect photoacoustic signal or both upon photoirradiation. 8. The near-infrared-absorbing composite particle of claim 7, wherein the near-infrared-absorbing dye is indocyanine green (ICG) and the metal cation is an iron ion. 9. The near-infrared-absorbing composite particle of claim 7, wherein the composite particle is a nanoparticle that is able to be dispersed as a colloidal particle in a bodily fluid. 10. The near-infrared-absorbing composite particle of claim 7, wherein the polymeric surfactant has a molecular weight of 7,500 to 15,000. 11. The near-infrared-absorbing composite particle of claim 7, wherein the particle of the polymeric surfactant further supports an additive selected from the group consisting of a therapeutic agent, a diagnostic agent, and a contrast agent is further supported in. 12. The near-infrared-absorbing composite particle of claim 7, wherein the anion of the near-infrared-absorbing dye is contained in an amount of 0.4 to 40 parts by weight, the metal cation in an amount of 0.1 to 10 parts by weight, and the polymeric surfactant in an amount of 50 to 99.5 parts by weight, relative to 100 parts by weight of the near-infrared-absorbing composite particle. 13. The near-infrared-absorbing composite particle of claim 7, wherein the near-infrared-absorbing composite particle is a heat source that is able to be heated to a temperature of 45° C. or higher through the photothermal effect. 14. The near-infrared-absorbing composite particle of claim 7, wherein the near-infrared-absorbing composite particle is prepared by the method of claim 1. 15. A method for using the near-infrared-absorbing composite particle of claim 7 as a photothermal therapeutic agent, a diagnostic agent, an imaging or mapping probe, a drug carrier, or a combination thereof that absorbs light in the near-infrared region and generates heat. 16. A method for photothermal treatment, comprising: (a) administering the near-infrared-absorbing composite particle of claim 7 to a patient; and(b) applying photoirradiation to allow the near-infrared-absorbing composite particle to absorb light in the near-infrared region and generate heat. 17. The method of claim 16, wherein step (a) is a step to administer the near-infrared-absorbing composite particle to the blood vessel of a patient to be accumulated in a cancer cell, and step (b) is a step to perform a photothermal treatment of the cancer cell via photoirradiation. 18. A method for realizing photothermal or photoacoustic imaging or mapping, comprising: (a) administering the near-infrared-absorbing composite particle of claim 7 to a subject; and(b) applying photoirradiation to allow the near-infrared-absorbing composite particle to absorb light in the near-infrared region and generate heat and thereby provide a photothermal or photoacoustic signal or image.
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