COMPOSITIONS COMPRISING A CANNABINOID AND SPILANTHOL
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-031/352
A61P-001/16
A61K-031/16
출원번호
17188023
(2021-03-01)
공개번호
20210177800
(2021-06-17)
발명자
/ 주소
KOREN, Zohar
출원인 / 주소
KOREN, Zohar
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
Provided herein are fixed-dose combination (FDC) compositions comprising therapeutically effective amounts of at least one cannabinoid and spilanthol whether as essentially pure isolates or synthetics or as components of essential oils or plant extracts or combinations thereof. The compositions are
Provided herein are fixed-dose combination (FDC) compositions comprising therapeutically effective amounts of at least one cannabinoid and spilanthol whether as essentially pure isolates or synthetics or as components of essential oils or plant extracts or combinations thereof. The compositions are formulated as pharmaceutical compositions, nutraceuticals, cosmeceuticals, nutricosmetics, cosmetics, or food products. The pharmaceutical compositions are useful for the treatment of a gastro-enteric disease selected from the group consisting of irritable bowel disease, Crohn's disease, colitis, irritable bowel syndrome, and acute and chronic pancreatitis or of sepsis. Other pharmaceutical uses are as anti-allergic, anti-inflammatory, immunomodulator, antioxidant, anti-microbial, antibacterial, antifungal, antiviral, antinociceptive, analgesic, anesthetic, anti-cancer, apoptosis inducing, antiscorbutic, antipyretic, anti-malarial, addiction mitigatory, anxiolytic, anti-depressant, diuretic, anti-diarrheal, vasodilator or aphrodisiac agents. The pharmaceutical compositions of this invention exhibit a synergistic effect.
대표청구항▼
1. A composition comprising a therapeutically effective amount of at least one cannabinoid, a therapeutically effective amount of spilanthol and a pharmaceutically acceptable carrier. 2. The composition of claim 1, wherein the at least one cannabinoid and the spilanthol, whether isolate or synthetic
1. A composition comprising a therapeutically effective amount of at least one cannabinoid, a therapeutically effective amount of spilanthol and a pharmaceutically acceptable carrier. 2. The composition of claim 1, wherein the at least one cannabinoid and the spilanthol, whether isolate or synthetic, are essentially pure having an assay of at least 95%. 3. The composition of claim 1, wherein the at least one cannabinoid is a component of a Cannabis essential oil or extract and wherein the spilanthol is a component of a spilanthol-containing essential oil or extract. 4. The composition of claim 1, wherein the at least one cannabinoid, whether isolate or synthetic is essentially pure having an assay of at least 95%, and wherein the spilanthol is a component of a spilanthol-containing essential oil or extract. 5. The composition of claim 1, wherein the at least one cannabinoid is a component of a Cannabis essential oil or extract and wherein the spilanthol is an essentially pure spilanthol isolate or essentially pure synthetic spilanthol. 6. The composition of claim 1, further comprising at least one additional ingredient selected from phytochemicals, an essential oil, a carrier oil, an antibacterial agent, an antioxidant, an anti-inflammatory agent, anti-viral agent, an antifungal agent, an anti-microbial agent, a chemotherapeutic agent, an immune-oncology agent, an immune-apoptosis inducing agent, an anti-diarrheal agent, an anti-histamine, a probiotic, a vitamin, a colorant, a buffer, an emulsifier, a sun screen, a moisturizer, an analgesic agent, an anti-depressant agent, a skin nutrient, a medicinal herbal extract, a flavor, a flower essence, a protein, a lubricant, a buffering agent, a bulking agent, a physiologically suitable carrier, and an inactive excipient. 7. The composition according to claim 1, wherein the at least one cannabinoid is selected from the group consisting of tetrahydrocannabinol (THC), Isotetrahydrocannabinol (iso-THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabinol (CBN), cannabinolic acid (CBNA), 30 cannabinol methyl ether (CBNM), cannabinol-C4 (CBN-C4), cannabinol-CZ (CBN-C2), cannabiorcol (CBN-Cl), cannabinodiol (CBND), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabigerolic acid monomethyl ether (CBGAM), cannabigerol monomethyl ether (CBGM), cannabigerovarinic acid (CBGVA), cannabichromene (CBC), cannabichromanon (CBCN), cannabichromenic acid (CBCA), cannabichromevarin (CBCV), cannabichromevarinic acid (CBCVA), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabielsoin (CBE), cannabielsoic acid A (CBEA-A), cannabielsoic acid B (CBEA-B), cannabigerovarin (CBGV), cannabidiolic acid (CBDA), cannabidiol monomethyl ether (CBDM), cannabidiol-C4 (CBD-C4), cannabidivarinic acid (CBDVA), and cannabidiorcol (CBD-Cl), cannabicyclol (CBL), cannabicyclolic acid (CBLA), cannabicyclovarin (CBLV), cannabitriol, cannabitriolvarin (CBTV), ethoxy-cannabitiolvarin (CBTVE), cannabivarin (CBV), cannabidivarin (CBVD), cannabitriol, cannabitriolvarin (CBTV), ethoxy-cannabitiolvarin (CBTVE), cannabifuran (CBF), dehydrocannabifuran (DCBF), and cannabiripsol (CBR), combinations thereof, pharmaceutically acceptable salts thereof, solvates, metabolites, metabolic precursors, isomers and derivatives thereof. 8. The composition of claim 1, wherein the at least one cannabinoid is CBD. 9. The composition of claim 1, wherein the at least one cannabinoid is THC. 10. The composition of claim 1, wherein formulated in the form of a pharmaceutical composition, a nutraceutical, a cosmeceutical, a nutricosmetic, a cosmetic composition, a body care product, a personal hygiene product or a food product. 11. The composition of claim 1, wherein the composition is formulated as a single unit dosage form comprising therapeutically effective amounts of spilanthol and at least one cannabinoid or wherein the composition is formulated as two or more units of dosage forms, at least one of which comprises essentially pure spilanthol, a spilanthol-containing extract or a spilanthol-containing essential oil, and at least one dosage form comprises Cannabis plant extract, Cannabis plant essential oil, or at least one essentially pure cannabinoid. 12. A method of treatment, prevention or amelioration of a condition amenable to treatment, prevention or amelioration comprising administering to a patient in need thereof a fixed-dose combination composition comprising a therapeutically effective amount of at least one cannabinoid, a therapeutically effective amount of spilanthol and a pharmaceutically acceptable carrier. 13. The method of claim 12, wherein the condition is a gastro-enteric disease, wherein the disease is selected from the group consisting of irritable bowel disease, Crohn's disease, colitis, irritable bowel syndrome, acute or chronic pancreatitis, colitis, and inflammatory bowel disease. 14. The method of claim 12, wherein the at least one cannabinoid is CBD and the condition is a gastro-enteric disease, comprising administering to the patient in need thereof the composition, wherein the composition comprises from about 5 mg to about 500 mg CBD and from about 1 mg to about 100 mg spilanthol. 15. The method of claim 12, wherein the condition is sepsis. 16. The method of claim 12, wherein co-administration of the composition comprising the spilanthol and the at least one cannabinoid results in a therapeutic effect selected from a synergistic effect, an additive effect, a potentiating effect and any combination thereof. 17. The method of claim 15, wherein the co-administration of the composition comprising the at least one cannabinoid and the spilanthol exhibits a synergistic therapeutic 15 effect of at least 100%, at least 300% or at least 500% higher than the therapeutic effect of the at least one cannabinoid or of spilanthol respectively, administered separately in a similar amount. 18. The method of claim 12, wherein the at least one cannabinoid is CBD. 19. The method of claim 12, wherein the at least one cannabinoid is THC. 20. The method of claim 12, wherein the composition is used an anti-allergic, anti-inflammatory, immunomodulator, antioxidant, anti-microbial, antibacterial, antiacne, antifungal, antiviral, antinociceptive, analgesic, anesthetic, anti-cancer, apoptosis inducing, antiscorbutic, antipyretic, anti-malarial, addiction mitigatory, anxiolytic, anti-depressant, diuretic, anti-diarrheal, vasodilator or aphrodisiac composition.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.