[미국특허]
Anticancer Composition of Traditional Chinese Medicine and Preparation Method Thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
A61K-031/704
A61K-036/481
A61K-036/9066
A61K-036/902
A61K-036/638
A61K-036/484
A61K-036/539
A61K-036/28
A61K-031/05
A61K-009/00
A61K-009/48
A61K-009/16
출원번호
16713450
(2019-12-13)
공개번호
20210177873
(2021-06-17)
발명자
/ 주소
SUN, Deyu
출원인 / 주소
SUN, Deyu
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
A medication of natural Chinese medicine with sustained release for cancer treatment and its preparation method thereof contains active ingredients of: ginsenoside, Astragalus polysaccharide, zedoary (Curcuma zedoaria), river bulrush (Sparganium stolonferum Buch.-Ham), Ternstroemia gymnanthera, Fruc
A medication of natural Chinese medicine with sustained release for cancer treatment and its preparation method thereof contains active ingredients of: ginsenoside, Astragalus polysaccharide, zedoary (Curcuma zedoaria), river bulrush (Sparganium stolonferum Buch.-Ham), Ternstroemia gymnanthera, Fructus Ligustri Lucidi, licorice, Chinese skullcap (Scutellaria baicalnsis Georgi), Sculellaria barbata, paclitaxel, Silybum marianum (L.) Gaertn., and Cannabidiol (CBD). The drug can restore body balance and promote self-recovery. The drug can be used as an alternative medicine or can be used in combination with conventional cancer treatment, and is especially target for patients suffered from toxic side effects of radiotherapy and chemotherapy, which can increase the efficiency and reduce the toxicity of conventional cancer treatment and eliminate side effects of vomiting, hair loss, and unbearable soreness of the body.
대표청구항▼
1. A medication of traditional Chinese medicine for cancer treatment, comprising: 5-10 grams of ginsenoside, 7-15 grams of Astragalus polysaccharide, 10-20 grams of zedoary (Curcuma zedoaria), 10-15 grams of river bulrush (Sparganium stoloniferum Buch.-Ham), 10-15 grams of extract of Ternstroemia gy
1. A medication of traditional Chinese medicine for cancer treatment, comprising: 5-10 grams of ginsenoside, 7-15 grams of Astragalus polysaccharide, 10-20 grams of zedoary (Curcuma zedoaria), 10-15 grams of river bulrush (Sparganium stoloniferum Buch.-Ham), 10-15 grams of extract of Ternstroemia gymnanthera, 12-20 grams of Fructus Ligustri Lucidi, 5-9 grams of licorice, 12-19 grams of Chinese skullcap extract (Scutellaria baicalnsis Georgi), 15-20 grams of Sculellaria barbata, 13 grams of paclitaxel, 15-20 grams of micropowder of Silybum marianum (L.) Gaertn., and 25-50% by percentage weight of Cannabidiol powder. 2. The medication of traditional Chinese medicine for cancer treatment according to claim 1, wherein said medication is in an oral form. 3. The medication of traditional Chinese medicine for cancer treatment according to claim 2, wherein said medication is in the form of a coated pellet. 4. The medication of traditional Chinese medicine for cancer treatment according to claim 2, wherein said medication is in the form of an oral liquid. 5. The medication of traditional Chinese medicine for cancer treatment according to claim 2, wherein said medication is in the form of a capsule. 6. The medication of traditional Chinese medicine for cancer treatment according to claim 3, wherein said medication is prepared by the steps of: (a) Carrying out extraction for zedoary (Curcuma zedoaria), river bulrush, Fructus Ligustri Lucidi, licorice, and Sculellaria barbata, to obtain a first composition;(b) Mixing ginsenoside, Astragalus polysaccharide, Ternstroemia gymnanthera extract, Chinese skullcap extract, Silybum marianum (L.) Gaertn. micropowder, paclitaxel, CBD powder and starch by a mixer to obtain a second composition;(c) Placing the first composition, the second composition, and microcrystalline cellulose in a fluidized bed, and spraying distilled water so that the first composition, the second composition, and the microcrystalline cellulose are bonded to form pellets;(d) Allowing the pellets to grow to a preset size, and then stopping spraying the distilled water and drying properly; and(e) Screening and selecting the pellets with a size of 30-70 meshes; and(f) Putting the pellets in a boiling bed, spraying a coating liquid for sustained release on surfaces of the pellets to form a coating until a weight gain of the coating reaches 5% of total weight of the pellets so that a coated pellet form is obtained. 7. The medication of traditional Chinese medicine for cancer treatment according to claim 6, wherein the step (e) is replaced by the step of: (e′) Screening and selecting the pellets with a size of 30-60 meshes. 8. The medication of traditional Chinese medicine for cancer treatment according to claim 4, wherein said medication is prepared by the steps of: (a) Mixing 5-10 grams of ginsenoside, 7-15 grams of Astragalus polysaccharide, 10-20 grams of zedoary (Curcuma zedoaria), 10-15 grams of river bulrush (Sparganium stolonferum Buch.-Ham), 10-15 grams of extract of Ternstroemia gymnanthera, 12-20 grams of Fructus Ligustri Lucidi, 5-9 grams of licorice, 12-19 grams of Chinese skullcap extract (Scutellaria baicalnsis Georgi), 15-20 grams of Sculellaria barbata, 13 grams of paclitaxel, 15-20 grams of micropowder of Silybum marianum (L.) Gaertn., 50% of Cannabidiol (CBD) aqueous solution, 16% of glucose, and 5 grams of isomalto-oligosaccharides to form a mixture;(b) Adding distilled water with five times of volume of the mixture and carrying out extraction at 80° C. for one hour and filtering, then concentrating the filtrate at 80° C. under reduced pressure to form a mixture concentrate; and(c) Mixing, filtering, and sterilizing the mixture concentrate to obtain an oral liquid. 9. The medication of traditional Chinese medicine for cancer treatment according to claim 5, wherein said medication is prepared by the steps of: (a) Mixing and dissolving 5-10 grams of ginsenoside, 7-15 grams of Astragalus polysaccharide, 10-20 grams of zedoary, 10-15 grams of river bulrush, 10-15 grams of extract of Ternstroemia gymnanthera, 12-20 grams of Fructus Ligustri Lucidi, 5-9 grams of licorice, 12-19 grams of Chinese skullcap extract, 15-20 grams of Sculellaria barbata, 13 grams of paclitaxel, 15-20 grams of micropowder of Silybum marianum (L.) Gaertn., 25-50% of CBD powder by percentage weight, and povidone K15 in absolute ethanol until completely dissolved to form a mixture;(b) Adding inactive auxiliary materials to the mixture to prepare a pellet form;(c) Coating the pellet form with a coating liquid for sustained release to form a coated pellet form; and(d) Filling the coated pellet form into capsule form. 10. A method of preparing a medication of traditional Chinese medicine with sustained release for cancer treatment, comprising the steps of (a) preparing ginsenoside, Astragalus polysaccharide, zedoary, river bulrush, Ternstroemia gymnanthera extract, Fructus Ligustri Lucidi, licorice, Chinese skullcap extract, Sculellaria barbata, paclitaxel, micropowder of Silybum marianum (L.) Gaertn., and 25-50% by percentage weight of Cannabidiol powder into a pellet, and(b) coating the pellet with a coating liquid for sustained release to form a coated pellet form. 11. The method of preparing a medication of traditional Chinese medicine with sustained release for cancer treatment according to claim 10, wherein the medication comprises: weight of: 2.19-6.30% ginsenoside, 3.07-9.22% Astragalus polysaccharide, 4.39-12.10% zedoary (Curcuma zedoaria), 4.39-9.45% river bulrush (Sparganium stolonferum Buch.-Ham), 4.39-9.45% Ternstroemia gymnanthera extract, 5.26-12.30% Fructus Ligustri Lucidi, 2.18-5.72% licorice, 5.26-11.78% Chinese skullcap extract, 6.58-12.61% Sculellaria barbata, 15.54-8.55% paclitaxel, 6.58-12.61% Silybum marianum (L.) Gaertn. micropowder, and 25-50% Cannabidiol powder, by percentage. 12. The method of preparing a medication of traditional Chinese medicine with sustained release for cancer treatment according to claim 11, wherein the step (a) further comprises the steps of: (aa) Carrying out extraction for zedoary (Curcuma zedoaria), river bulrush, Fructus Ligustri Lucidi, licorice, and Sculellaria barbata, to obtain a first composition;(ab) Mixing ginsenoside, Astragalus polysaccharide, Ternstroemia gymnanthera extract, Chinese skullcap extract, Silybum marianum (L.) Gaertn. micropowder, paclitaxel, CBD powder and starch by a mixer to obtain a second composition;(ac) Placing the first composition, the second composition, and microcrystalline cellulose in a fluidized bed, and spraying distilled water so that the first composition, the second composition, and the microcrystalline cellulose are bonded to form pellets;(ad) Allowing the pellets to grow to a preset size, and then stopping spraying the distilled water and drying properly; and(ae) Screening and selecting the pellets with a size of 30-70 meshes. 13. The method of preparing a medication of traditional Chinese medicine with sustained release for cancer treatment according to claim 12, wherein the step (ae) is replaced by the step of: (ae′) Screening and selecting the pellets with a size of 30-60 meshes. 14. The method of preparing a medication of traditional Chinese medicine with sustained release for cancer treatment according to claim 11, wherein the step (a) further comprises the steps of: (aa′) Mixing and dissolving ginsenoside, Astragalus polysaccharide, zedoary, river bulrush, Ternstroemia gymnanthera extract, Fructus Ligustri Lucidi, licorice, Chinese skullcap extract, Sculellaria barbata, paclitaxel, Silybum marianum (L.) Gaertn. micropowder. Cannabidiol powder and povidone K15 in absolute ethanol until completely dissolved to form a mixture; and(ab′) Adding inactive auxiliary materials to the mixture to prepare into pellets.
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