[미국특허]
PARTICLE CONFIRMING METHOD, PARTICLE TRAPPING CHIP, AND PARTICLE ANALYZING SYSTEM
원문보기
IPC분류정보
국가/구분
United States(US) Patent
공개
국제특허분류(IPC7판)
G01N-015/14
G06K-009/32
G06K-009/46
G06K-009/62
C12Q-001/6813
출원번호
16970307
(2019-11-11)
공개번호
20210364410
(2021-11-25)
우선권정보
JP-2018-240079 (2018-12-21)
국제출원번호
PCT/JP2019/044100
(2019-11-11)
발명자
/ 주소
Hosokawa, Hiroyuki
Yotoriyama, Tasuku
Masuhara, Shin
Nakao, Isamu
출원인 / 주소
Sony Corporation
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
To provide a technology for confirming that a desired particle is recovered in single cell analysis. The present technology provides a particle confirming method including a correlating step of correlating ID information possessed by a particle trapped in a well in a particle trapping region with po
To provide a technology for confirming that a desired particle is recovered in single cell analysis. The present technology provides a particle confirming method including a correlating step of correlating ID information possessed by a particle trapped in a well in a particle trapping region with position information of the well, a discharging step of discharging the particle from the well, an ID information acquiring step of acquiring ID information of the particle after the discharging step, and a confirming step of confirming the position of the well in which the particle has been trapped, on the basis of the acquired ID information. In addition, the present technology also provides a particle trapping chip and a particle analyzing system to be used for carrying out the method.
대표청구항▼
1. A particle confirming method comprising: a correlating step of correlating identification information possessed by a particle trapped in a well in a particle trapping region with position information of the well;a discharging step of discharging the particle from the well;an identification inform
1. A particle confirming method comprising: a correlating step of correlating identification information possessed by a particle trapped in a well in a particle trapping region with position information of the well;a discharging step of discharging the particle from the well;an identification information acquiring step of acquiring identification information of the particle after the discharging step; anda confirming step of confirming whether the particle has been trapped in the well possessing the position information, on a basis of the acquired identification information. 2. The particle confirming method according to claim 1, further comprising: a trapping step of trapping the particle through a linker fixed to the well in the particle trapping region. 3. The particle confirming method according to claim 2, wherein the trapping step includes a labeling step of labeling the particle trapped in the well to impart identification information to the particle. 4. The particle confirming method according to claim 3, wherein in the labeling step, the particle is labeled with fluorescence, a color, an electric charge, a magnetic charge, an oligonucleic acid, or a peptide to impart identification information to the particle. 5. The particle confirming method according to claim 3, wherein in the labeling step, adjacent wells in the particle trapping region have different label elements, and the particles trapped in the adjacent wells are labeled with different label elements. 6. The particle confirming method according to claim 3, wherein in the labeling step, the wells in the particle trapping region are arranged to form a plurality of rows or columns, the adjacent two rows or columns have mutually different label elements, and the particles trapped in the wells in the adjacent rows or columns are labeled with the different label elements. 7. The particle confirming method according to claim 1, wherein the correlating step further includes an image acquiring step of acquiring an image of the particle trapping region, andfluorescence, a color, or a size or shape of a particle is acquired from the image as identification information and the identification information and the position information are correlated with each other. 8. The particle confirming method according to claim 1, wherein in the discharging step, a plurality of particles having identification information is discharged successively. 9. The particle confirming method according to claim 8, wherein in the confirming step, an order of discharge of the plurality of particles is referred to. 10. The particle confirming method according to claim 8, wherein in the discharging step, the discharge is temporarily stopped after a predetermined number of particles are discharged successively. 11. The particle confirming method according to claim 8, wherein in the discharging step, a particle to be a mark is discharged after a predetermined number of particles are discharged successively. 12. The particle confirming method according to claim 8, wherein in the discharging step, two or more particles discharged successively have different pieces of identification information. 13. The particle confirming method according to claim 3, wherein the particle trapping region is divided into a plurality of fields, andthe well includes a label element for specifying the field in which the well is disposed. 14. The particle confirming method according to claim 2, wherein the discharging step further includes a light irradiation step of irradiating the linker fixed to the well with light to cut the linker. 15. The particle confirming method according to claim 1, wherein the particle confirming method further includes a particle moving step of causing the particle discharged from the well in the discharging step to pass through a channel, andin the identification information acquiring step, the identification information is acquired from the particle passing through the channel or the particle having passed through the channel. 16. The particle confirming method according to claim 1, wherein in the confirming step, a group of a predetermined number of successive particles is disposed of when an order of pieces of identification information of the particles discharged in the discharging step and an order of pieces of identification information of the particles acquired in the identification information acquiring step are different from each other. 17. The particle confirming method according to claim 1, further comprising: a particle fractionating step. 18. The particle confirming method according to claim 1, wherein the particle trapped in the well in the correlating step has two or more different pieces of identification information. 19. The particle confirming method according to claim 1, further comprising: a nucleic acid sequence step of acquiring identification information of the particle by a nucleic acid sequence treatment, in the identification information acquiring step. 20. A particle trapping chip comprising: a particle trapping region having at least one well, whereineach of the at least one well has a label element that is able to be transferred from the well to a particle. 21. The particle trapping chip according to claim 20, wherein the label element is fixed to each well through a linker, and the fixation of the label element through the linker is able to be canceled. 22. The particle trapping chip according to claim 20, wherein adjacent wells in the particle trapping region have different label elements. 23. The particle trapping chip according to claim 20, wherein the wells in the particle trapping region are arranged such as to form a plurality of rows or columns, and two adjacent rows or columns have mutually different label elements. 24. A particle analyzing system comprising: a particle trapping chip that includes a particle trapping region having at least one well, each of the at least one well having a label element capable of being transferred from the well to a particle;a particle recovering section that recovers the particle discharged from the at least one well; andan identification information acquiring section that acquires identification information possessed by the discharged particle.
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