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특허 상세정보

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내보내기 페이스북 공유 카카오톡 공유

Antibody steric hindrance immunoassay with two antibodies

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) G01N-031/00    C12K-001/04   
미국특허분류(USC) 195/1035 ; R ; 23/230B ; 424/12 ; 424/1
출원번호 US-0425376 (1973-12-17)
발명자 / 주소
  • Rubenstein Kenneth Edward (Palo Alto CA) Leute Richard K. (Sunnyvale CA)
출원인 / 주소
  • Syva Company (Palo Alto CA 02)
인용정보 피인용 횟수 : 281  인용 특허 : 0
초록
▼

A novel immunoassay is provided, as well as particular reagents, for determining the presence of a ligand. A Reagent is employed having at least two epitopes, one of the epitopes being common with the ligand, and the other epitopes being foreign to the ligand. The two epitopes are positioned in the Reagent so that antibody bound to one of the epitopes sterically inhibits the binding of antibody to the second epitope. In carrying out the assay, the sample, the Reagent, and antibodies to the two epitopes are combined. Because of the steric inhibition to th...

대표
청구항
▼

A method for determining the presence of a ligand in an unknown suspected of containing said ligand which comprises: combining in an aqueous medium said unknown, antiligand, anti(detector ligand) and Reagent, wherein said Reagent has a pair of epitopes in close proximity so that simultaneous binding of receptors to said pair of epitopes is sterically inhibited, wherein one of said pair of epitopes is recognized by said antiligand and the other of said pair of epitopes is recognized by said anti(detector ligand); determining by a detectant the amount of r...

이 특허를 인용한 특허 (281)

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  153. Gazit, Ehud; Reches, Meital, Method of forming a fiber made of peptide nanostructures.
  154. Gazit, Ehud; Reches, Meital, Method of forming a fiber made of peptide nanostructures.
  155. Hershkovitz, Oren; Bar-Ilan, Ahuva, Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides.
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  157. Hornby William E. (Berkshire GB2) Morris David L. (Buckinghamshire GB2), Method of preparing an enzyme-labeled ligand for use in specific binding assays and the labeled conjugate produced there.
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  160. Gazit, Ehud, Method of screening for compounds that disaggregate amyloid aggregates.
  161. John W. Hadden, Method to diagnose and monitor cellular immune deficiencies.
  162. Deikman, Jill; Schwartz, Steven H.; Zheng, Wei; Gabriels, Suzan Herma Elisabeth Johanna; Hresko, Michelle C.; Li, Xiangqian; Tao, Nengbing; Williams, Deryck J.; Xiong, Hui, Methods and compositions for delaying senescence and improving disease tolerance and yield in plants.
  163. Davis, Noa; Elkeles, Adi; Terkieltaub, Dov; Chausovsky, Alexander, Methods and compositions for identifying a cell phenotype.
  164. Fillatti, Joanne J.; Froman, Byron; Mroczka, Andrew; Peel, Gregory John, Methods and compositions for increasing invertase activity in plants.
  165. Neufeld, Gera; Akiri, Gal; Vadasz, Zahava; Gengrinovitch, Stela, Methods and compositions for modulating angiogenesis.
  166. Crawford, Michael J.; Li, Xiangqian; Kapoor, Mahak; Williams, Deryck Jeremy, Methods and compositions for plant pest control.
  167. Crawford, Michael J.; Li, Xiangqian; Shortt, Barry J.; Williams, Deryck Jeremy, Methods and compositions for plant pest control.
  168. Smith, Victoria; Ogg, Scott; Van Vlasselaer, Peter; Barry, Vivian E.; Marshall, Derek; Holzer, Alison Kay; Rodriguez, Hector; Oyasu, Miho; McCauley, Scott Alan; Garcia, Carlos Aurelio; Biermann, Donna Hiroko Tokuoka, Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis.
  169. Smith, Victoria; Ogg, Scott; Van Vlasselaer, Peter; Barry, Vivian E.; Marshall, Derek; Holzer, Alison Kay; Rodriguez, Hector; Oyasu, Miho; McCauley, Scott Alan; Garcia, Carlos Aurelio; Biermann, Donna Hiroko Tokuoka, Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis.
  170. Ader, Daniel; Dimmic, Matt W.; Li, Zhaolong; Sammons, Robert Douglas; Shah, Ronak Hasmukh; Tao, Nengbing; Wang, Dafu, Methods and compositions for weed control.
  171. Ader, Daniel; Fiinnessy, John J; Li, Zhaolong; Masucci, James D; Shah, Ronak Hasmukh; Tao, Nengbing; Taylor, Jennifer Chou, Methods and compositions for weed control.
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  175. Idelevich, Pavel; Elkeles, Adi; Terkieltaub, Dov; Eyal, Ami; Gelvan, Dan Jacob, Methods and kits for differential staining of abnormal urinary system cells.
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  184. Roiz, Levava; Schwartz, Betty; Smirnoff, Patricia; Shoseyov, Oded, Methods of and compositions for inhibiting the proliferation of mammalian cells.
  185. Roiz,Levav; Schwartz,Betty; Smirnoff,Patricia; Shoseyov,Oded, Methods of and compositions for inhibiting the proliferation of mammalian cells.
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  188. Peled, Tony; Steinhardt, Yair, Methods of culturing and expanding mesenchymal stem cells.
  189. Feinstein,Elena; Mor,Orna, Methods of diagnosing bladder cancer.
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  191. Mitrani, Eduardo N., Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs.
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  200. Park, Dongsu; Spencer, David; Lapteva, Natalia, Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods.
  201. Paris, Daniel; Town, Terrence C.; Mullan, Michael J., Modulation of the phospholipase A2 pathway as a therapeutic.
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  209. Joseph Rajiv ; Dou Dexian, Neuronal-neonatal gene: neuronatin.
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  216. Hochberg, Avraham, Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer.
  217. Ronen, Gil; Rabinovich, Larisa; Meissner, Rafael; Karchi, Hagai, Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same.
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  233. Gazit, Ehud, Peptides and methods using same for diagnosis and treatment of amyloid-associated disease.
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  236. Gazit, Ehud, Peptides directed for diagnosis and treatment of amyloid-associated diseases.
  237. Neufeld, Gera; Akiri, Gal; Vadasz, Zahava; Gengrinovitch, Stela, Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors.
  238. Stein,Hanan; Zilberstein,Aviah; Miller,Gadi; Kapulnik,Yoram, Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby.
  239. Sammons, Robert D; Ivashuta, Sergey; Liu, Hong; Wang, Dafu; Feng, Paul C. C.; Kouranov, Andrei Y; Andersen, Scott E, Polynucleotide molecules for gene regulation in plants.
  240. Ayal, Sharon; Karchi, Hagai; Gold, Evgenia; Bekerman, Laura, Polynucleotides and polypeptides involved in plant fiber development and methods of using same.
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  243. Emmanuel, Eyal; Ronen, Gil; Savir, Noa, Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants.
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  245. Ronen, Gil; Karchi, Hagai; Diber, Alex; Vinocur, Basia Judith; Ayal, Sharon; Emmanuel, Eyal; Gang, Michael; Dimet, Dotan, Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same.
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  247. Buckler Robert T. (Edwardsburg MI) Carrico Robert J. (Elkhart IN), Propranolol immunogen and antibodies.
  248. Rousso, Benny; Sabbah, Hani N., Protein activity modification.
  249. Buechler, Kenneth F., Rapid evaluation of the ratio of biological molecules.
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  251. Yan Cheng F. ; Oh Chan S. ; Cheng Anthony K., Reagents and methods for the rapid and quantitative assay of pharmacological agents.
  252. Rubenstein ; Kenneth E. ; Leute ; Richard K., Receptor steric hindrance immunoassay for receptor determination.
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  256. Karlish, Steven J. D.; Katz, Adriana; Tal, Daniel M.; Marcovich, Arie, Selective inhibitors of α2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents.
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  266. Kollet, Orit; Lapidot, Tsvee, Stem cells having increased sensitivity to SDF-1 and methods of generating and using same.
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