[특허]Hemo dialyzer employing two dialysate solutions

Hemo dialyzer employing two dialysate solutions 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01D-031/00 B01D-013/00
출원번호	US-0461461 (1974-04-16)
발명자 / 주소	Fialkoff Sheldon L. (Brooklyn NY) Ackerman Roy Alan (Cambridge MA)
출원인 / 주소	Tri-Flo Research Laboratories, Ltd. (Jamaica NY 02)
인용정보	피인용 횟수 : 30 인용 특허 : 0

초록 ▼

A novel dialysis system is disclosed for both making and using a hemo dialyzer employing two novel dialysate solutions. The dialyzer per se used in the system comprises a clamp assembly enclosing three parallel plate dialyzer boards. Between each pair of boards a pair of semipermeable filtration media is enclosed. A total of six chambers is formed, three between each pair of dialyzer boards. The two chambers bounded by the semi-permeable filtration media form a portion of the flow path for the liquid to be dialyzed, in this case, blood. Of the remaining four chambers, two form a portion of a flow path of one dialysate solution and the other two chambers form a portion of the flow path for the remaining dialysate solution. Suitable connections are made on each of the boards for the introduction and withdrawal of the two dialysate solutions and suitable ports are provided to communicate with the membrane formed chambers for the introduction and withdrawal of the liquid to be dialyzed. The two novel dialysate solutions are similar in that neither contain any concentration of urea. However, one of the dialysate solutions is hypertonic, that is, it contains a greater concentration of other constituents to be dialyzed than does the liquid to be dialyzed. The other dialysate solution is hypotonic with respect to the other constituents to be dialyzed, that is, it contains a lower concentration of these constituents than does the liquid to be dialyzed. The rate of dialysis is greatly increased by the use of two different dialysate solutions as compared with the prior art processes which employ one dialysate solution. This greatly-increased dialysis rate enables the use of the parallel plate dialyzer, the use of which had substantially been discontinued.

대표청구항 ▼

A method of purifying blood in which blood is subjected to filtration to remove impurities thereform, said filtration comprising, exposing blood between two zones, the first zone containing a hypotonic solution with respect to blood constituents, both said zones being separated from said flow of blood by a semi-permeable filtration medium, the hypotonic solution being at a concentration sufficient to remove at least a portion of said blood impurities, the improvement comprising providing a hypertonic solution in said second zones, said hypertonic solution being hypertonic with respect to said blood constituents other than urea, both said hypertonic and hypotonic solutions having constituents in common with blood but at concentrations different therefrom to produce a concentration gradient with respect to said constituents, said concentrations being highest in said hypertonic solution and lowest in said hypotonic solution. whereby said concentration gradient produces an efflux of water from said blood by reason of the osmotic gradient which flow carries with it blood impurities effective to increase the dialysis rate.

이 특허를 인용한 특허 (30)

Storey L. Robert (Hollywood FL) Hall Robert C. (Pleasant Hill CA), Apparatus and method for preparation of a hemodialysis solution optionally containing bicarbonate.
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Callan, Robin; Van Schalkwijk, Walter A.; Cole, James J., Buffered compositions for dialysis.
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Callan, Robin; van Schalkwijk, Walter A.; Cole, James J., Buffered compositions for dialysis.
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Callan, Robin; van Schalkwijk, Walter A.; Cole, James J.; Ahmad, Suhail, Buffered compositions for dialysis.
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Lannoy, Jean-Michel, Citrate anticoagulation system for extracorporeal blood treatments.
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Lannoy, Jean-Michel, Citrate anticoagulation system for extracorporeal blood treatments.
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Shah, Dilip H.; Ing, Todd, Citrate-based dialysate chemical formulations.
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Shah, Dilip H.; Ing, Todd, Citrate-based dialysate chemical formulations.
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Shah, Dilip H.; Ing, Todd, Citrate-based dialysate chemical formulations.
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Shah, Dilip H.; Ing, Todd, Citrate-based dialysate chemical formulations.
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Shah, Dilip H.; Ing, Todd, Citrate-based dialysate chemical formulations.
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Peluso, Francesco; Anders, Tranaeus; Faict, Dirk; Balteau, Patrick R.; Gollier, Paul-Andre; Dewez, Jean-Luc; Henaut, Eric J.; Houwaert, Vincent; Lambert, Philippe, Containers and methods for manufacturing same.
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Ward David M. (San Diego CA) Mehta Ravindra L. (San Diego CA), Continuous hemodialysis using citrate.
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Sasaki Kanji (Yokohama JPX) Suehiro Tetsuro (Yokohama JPX) Okada Akira (Yokohama JPX), Device for removal of excess water from blood.
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Ash Stephen R. (Lafayette IN), Dialysis instrument with dialysate side pump for moving body fluids.
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Shah, Dilip H.; Ing, Todd, Dialysis system for preparing a citrate dialysate from a base concentrate and an acid concentrate.
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Schnell William J. (Wheeling IL), Dialyzer casing.
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Schnell William J. (Wheeling IL), Dual membrane mass transfer device.
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Babb Albert L. (Seattle WA) Scribner Belding H. (Seattle WA), Hemodialysis with sodium bicarbonate dialysate prepared in plural stages.
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Callan, Robin; Cole, James J., High citrate dialysate and uses thereof.
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Callan, Robin; Cole, James J., High citrate dialysate and uses thereof.
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Lannoy, Jean-Michel, Machine readable medium embodying instructions for citrate anticoagulation system for extracorporeal blood treatments.
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Veltman Preston L. (212 Old Country Rd. Severna Park MD 21146), Materials and method for preparing dialysis solutions containing bicarbonate ions.
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Caro Ricardo F. (1515 NW. 13th St. Corvallis OR 97330) Salter Robert J. (30636 Peterson Rd. Corvallis OR 97333), Membrane separation apparatus and method.
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Suzuki Takeshi (Tokushima JPX), Method of preparing mixed electrolyte powder for bicarbonate dialysis and powder mixture formed.
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Chang, Peter C.; Lannoy, Jean-Michael, Multi-part substitution infusion fluids and matching anticoagulants.
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Chang, Peter C.; Lannoy, Jean-Michel, Multi-part substitution infusion fluids and matching anticoagulants.
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Chang,Peter C.; Lannoy,Jean Michel, Multi-part substitution infusion fluids and matching anticoagulants.
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Marty Didier (6 ; rue Clemence Isaure 31000 Toulouse FRX) Abadie Albert (18 ; rue de Nimes 31400 Toulouse FRX) Mustin Michel (8 ; rue du Libre Echange 31000 Toulouse FRX), Process for preparation of a water for hemodialysis, and its application in renal hemodialysis.
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Babb Albert L. (Seattle WA) Scribner Belding H. (Seattle WA), Proportioning system for bicarbonate dialysate.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Hemo dialyzer employing two dialysate solutions 원문보기

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Hemo dialyzer employing two dialysate solutions 원문보기

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