[특허]Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type

[미국특허] Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/16
출원번호	US-0540584 (1975-01-13)
발명자 / 주소	Armstrong Douglas (Coral Springs FL)
출원인 / 주소	Coulter Diagnostics, Inc. (Hialeah FL 02)
인용정보	피인용 횟수 : 36 인용 특허 : 0

초록 ▼

A multi-purpose blood diluent for use in electronic enumeration of red and white blood cells and the determination of hemoglobin concentration and other classic parameters, mean cell volume and other measurements of blood cells and particles or measurements of blood cells and particles by means of particle analysis instrumentation of the Coulter type. The blood diluent is characterized as azide free, unreactive and osmotically balanced so as to be capable of affording reproducible and accurate hematological test results. The diluent employs an antibacterial agent which prevents adverse bacterial or fungi growths capable of interference with accurate counts and sodium fluoride to achieve stable conditions in red blood celll volume and aid in the complete conversion of hemoglobin in cyanmethemoglobin for hemoglobin determinations.

대표청구항 ▼

A multi-purpose blood diluent, which is both isotonic and osmotically balanced relative to the solutions in blood cells, to be analyzed for a plurality of classic parameters in an electronic particle analysis apparatus of the Coulter type consisting essentially of: a. an osmotically balanced solution of sodium chloride, potassium chloride, sodium di-hydrogen phosphate and di-sodium phosphate, b. sodium fluoride, c. 2-phenoxyethanol, d. an ethylenediamine tetracetic acid, said diluent being an aqueous electrolytic solution maintained at a pH of between 7.0 to 8.0 and at an osmolality of between 300 and 380 milliosmoles, and wherein the sodium fluoride services to stabilize red blood cell volume and aid in converting hemoglobin to cyanmethemoglobin for hemoglobin determination.

이 특허를 인용한 특허 (36) 인용/피인용 타임라인 분석

North ; Jr. Howard L. (Newfoundland NJ), Blood diluent.
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Riesgo Mirta I. ; Young Carole Jo, Blood diluent.
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Lapicola James D. (Martinez CA), Blood diluent for automatic and semi-automatic determination of white cells and method of utilizing same.
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Edmondson Sherburne M. (Sunnyvale CA) Luna Carlos E. (Campbell CA), Blood diluent for red blood cell analysis.
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Riesgo Mirta I. ; Young Carole Jo, Cyanide-free reagent and method for hemoglobin determination and leukocyte differentitation.
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Shenkin Mark Lee (Pembroke Pines FL), Detection of reticulocytes.
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Ledis Stephen L. (Hialeah FL) Chastain ; Jr. David L. (Ft. Lauderdale FL) Crews Harold R. (Miami FL), Differential lymphoid-myeloid determination of leukocytes in whole blood.
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Maples, John A.; Lopez, Lidice L.; Torke, Nancy, Dye compositions which provide enhanced differential fluorescence and light scatter characteristics.
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Gupta, Ravinder; Lee, Song Y.; Shen, Gene G.-Y.; Szydlo, Stephen; Deka, Chiranjit, Dyes and methods of detection of nucleic acid in immature red blood cells.
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Louderback Allan L. (9661 Longden Ave. Temple City CA 91780) Szatkowski Paul (24 Winthrop Rd. Bethel CT 06801), Hematology control.
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Vormbrock Rolf (Darmstadt DEX) Helger Roland (Darmstadt DEX), Hemolysing solution preparing hemolysed blood having a stabilized glucose content.
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Goldson, Wayne; Socarras, Sandra, Isotonic buffered composition and method that enables counting of cells.
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Goldson, Wayne; Socarras, Sandra, Isotonic buffered composition and method that enables counting of cells.
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Paul, Ronald D.; Rubio, Oilda; Careaga, Diana B.; Lopez, Lidice L.; Mylvaganam, Ravindra, Method for a fully automated monoclonal antibody-based extended differential.
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Paul, Ronald D.; Wyatt, James L.; Carrillo, Barbara; Rubio, Oilda; Careaga, Diana B.; Lopez, Lidice L., Method for a fully automated monoclonal antibody-based extended differential.
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Mylvaganam, Ravindra; Paul, Ronald D., Method for a rapid antibody-based analysis of platelet populations.
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Horton Allan ; Wyatt James L., Method for identification of reticulated cells.
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Shine Thomas Adam ; Shine Ian Basil, Method for testing a cell suspension.
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Deka Chiranjit ; Gordon Kristie M. ; Gupta Ravinder ; Horton Allan, Methods and compositions for rapid staining of nucleic acids in whole cells.
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Lary, Todd P.; Snow, Christopher W.; Riley, John S.; Burr, Robert C., Monitoring and control of droplet sorting.
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Carter James H. (Ft. Lauderdale FL) Ledis Stephen L. (Hialeah FL) Crews Harold R. (Miami FL), Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes.
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Carter James H. (Ft. Lauderdale FL) Ledis Stephen L. (Hialeah FL) Crews Harold R. (Miami FL), Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes.
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Carter James H. (Ft. Lauderdale FL) Ledis Stephen L. (Hialeah FL) Crews Harold R. (Miami FL), Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes.
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Crews Harold R. (Miami FL) Chastain ; Jr. Dave (Ft. Lauderdale FL) Ledis Stephen (Hialeah FL), Multi-purpose blood diluent for use in electronic blood analysis instrumentation.
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Crews Harold R. (Miami FL) Chastain ; Jr. Dave (Ft. Lauderdale FL) Ledis Stephen L. (Hialeah FL), Multi-purpose blood diluent for use in electronic blood analysis instrumentation.
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Runck Alan H. (Hollywood FL) Armstrong Douglas (Coral Springs FL) Hutchisson James T. (Miami Springs FL), Multiple analysis hematology reference control reagent and method of making the same.
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Lin Lily (Berkeley CA) Cimino George (Richmond CA) Zhu Yu S. (Richmond CA), Nucleic acid preparation methods.
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Herlyn,Meenhard; Kalabis,Jiri, Organotypic intestinal culture and methods of use thereof.
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Dubin ; Stephen, Osmotically balanced anticoaglant.
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Hunt Roger A. (Woodland WA 4), Platelet control composition.
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Ryan Wayne L. (Omaha NE), Platelet reference control and method of preparation.
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Forester John (2816 Assiniboine Ave. Winnipeg ; Manitoba CAX R3J 0B1), Preservative solutions containing sodium dehydroacetate with or without sodium borate decahydrate and/or disodium edetat.
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Crews Harold R. (Miami FL) Chastain ; Jr. David L. (Fort Lauderdale FL) Ledis Stephen L. (Hialeah FL), Process for preparing whole blood reference controls having long term stability.
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Crews Harold R. (Miami FL) Chastain ; Jr. David L. (Fort Lauderdale FL) Ledis Stephen L. (Hialeah FL), Process for preparing whole blood reference controls having long term stability, preconditioning diluent and media there.
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Armstrong ; Douglas, Stabilized hematological reagent solutions.
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Raaijmakers Christiaan E. (Deventer NLX), Stabilized multi-purpose blood diluent.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type 원문보기