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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0554731 (1975-03-03) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 293 인용 특허 : 0 |
A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a drug carrier permeable to the pass
A drug delivery device for administering a drug at a controlled rate for a prolonged period of time to produce a local or systemic physiological or pharmacological effect is comprised of a wall surrounding a reservoir containing a drug. The reservoir is formed of a drug carrier permeable to the passage of the drug and in which the drug has limited solubility. The wall is formed in at least a part of a drug release rate controlling material also permeable to the passage of the drug, but the rate of passage of the drug through the wall is lower than the rate passage of the drug through the drug carrier so that drug release by the wall is the drug release rate controlling step for releasing drug from the drug delivery device.
A delivery device for the controlled and continuous administration of drug to a body site over a prolonged period of time, said device comprising: a. a means for containing and releasing the drug at a controlled rate comprising a reservoir containing a dissolved drug portion and an undissolved repla
A delivery device for the controlled and continuous administration of drug to a body site over a prolonged period of time, said device comprising: a. a means for containing and releasing the drug at a controlled rate comprising a reservoir containing a dissolved drug portion and an undissolved replacement drug portion in a liquid carrier material permeable to the passage of the drug therethrough, said drug having limited solubility in said liquid carrier material; the replacement drug portion being present in an amount in excess of its solubility in the carrier material and in an amount sufficient to maintain the amount of the dissolved drug portion substantially constant during said prolonged period of time, said means further comprising: b. a shaped wall that surrounds the reservoir and is characterized by being insoluble in body fluid, maintaining its integrity during said prolonged period of time, and by being formed at least in part of a microporous polymer housing in its micropores a drug release rate controlling medium permeable to the passage of the drug but having a lower permeability to the drug than the permeability of the liquid carrier material to the drug; so that the device when placed at the body site, continuously releases drug from the reservoir of the body site at a physiologically or pharmacologically effective controlled rate by metered passage through the medium, the dissolved drug so released being replaced by the continuous dissolving of replacement drug in the carrier material so as to substantially maintain the amount of dissolved drug in the reservoir substantially constant during said prolonged time period.
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