[특허]Labeled liposome particle compositions and immunoassays therewith

[미국특허] Labeled liposome particle compositions and immunoassays therewith 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-031/00 G01N-033/16 G01N-023/00 A61K-037/00
출원번호	US-0906514 (1978-05-16)
발명자 / 주소	Ullman Edwin F. (Atherton CA) Brinkley John M. (Oakland CA)
출원인 / 주소	Syva Company (Palo Alto CA 02)
인용정보	피인용 횟수 : 151 인용 특허 : 3

초록 ▼

The subject invention concerns novel compositions for use in immunoassays, as well as immunoassays employing such novel compositions. The compositions comprise discrete charged colloidal particles comprised of small molecules which particles are capable of retaining their discrete character in an aqueous medium and composed of aggregates of lipophilic and/or amphiphilic organic molecules to which are bound non-covalently a label capable of producing a detectible signal and a ligand or an analog of the ligand capable of competing with a ligand for a ligand receptor. The discrete colloidal particle serves as a hub or nucleus for retaining the ligand or its analog and the label within a limited locus. The compositions are prepared by individually covalently bonding the ligand and the label, when not naturally lipophilic, to a lipophilic (includes amphiphilic) compound, normally a phospholipid. Depending upon the nature of the particle, the amphiphilic conjugated ligand and label are combined with the particle or alternatively may be combined with the compounds employed for preparing the particle under particle forming conditions. Particles are then obtained having the analog of the ligand and the label bound to the particle. The compositions find use in immunoassays where an interaction between the label and receptor provides a means for modulating a detectible signal. The interaction can be as a result of quenching or modification of fluorescence, where the label is a fluorescer, steric inhibition of the approach of a signal modifier to the label, such as a label receptor or with an enzyme label, an antienzyme or enzyme inhibitor, the inhibition of cleavage of an enzyme labile bond or the cooperative interaction of two labels, such as two enzymes, where the product of one enzyme is a substrate of another enzyme.

대표청구항 ▼

In an immunoassay for the determination of an analyte, where the analyte is a member of a specific binding pair consisting of ligand and antiligand and wherein a label is employed which provides a detectible signal, the value of which is affected by the proximity of said antiligand to said label due to the presence of the bulk of said antiligand or a compound conjugated to said antiligand which interacts with said label, wherein said immunoassay comprises combining in an aqueous medium: (1) a sample suspected of containing said analyte, (2) a reacgent comprising ligand or ligand analog and label, wherein said ligand analog is capable of specific binding to said antiligand, and (3) antiligand, when ligand is the analyte or said antiligand is conjugated with said compound which interacts with said label; and determining the value of said detectible signal as compared to said value determined with a sample having a known amount of analyte; the improvement which comprises employing as said reagent discrete colloidal particles comprised of a major portion of lipophilic compounds and a minor portion of label and ligand or ligand analog, wherein said label is covalently conjugated to at least one of said lipophilic compounds, and the ligand or ligand analog are lipophilic or made so by conjunction to a lipophilic compound.

이 특허에 인용된 특허 (3) 인용/피인용 타임라인 분석

Forgione Peter Salvatore (Stamford CT), Composition and method for the detection of syphilis.
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Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
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Maier ; Jr. ; Charles L., Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids.
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이 특허를 인용한 특허 (151) 인용/피인용 타임라인 분석

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Chad A. Mirkin ; Robert L. Letsinger ; Robert C. Mucic ; James J. Storhoff ; Robert Elghanian, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Chad A. Mirkin ; Robert L. Letsinger ; Robert C. Mucic ; James J. Storhoff ; Robert Elghanian, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Chad A. Mirkin ; Robert L. Letsinger ; Robert C. Mucic ; James J. Storhoff ; Robert Elghanian, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A.; Garimella, Viswanadham; Li, Zhi, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Park, So-Jung, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin,Chad A.; Letsinger,Robert L.; Li,Zhi, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin,Chad A.; Letsinger,Robert L.; Mucic,Robert C.; Storhoff,James J.; Elghanian,Robert; Taton,Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin,Chad A.; Letsinger,Robert L.; Mucic,Robert C.; Storhoff,James J.; Elghanian,Robert; Taton,Thomas Andrew, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin,Chad A.; Letsinger,Robert L.; Mucic,Robert C.; Storhoff,James J.; Elghanian,Robert; Taton,Thomas Andrew, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin,Chad A.; Letsinger,Robert L.; Mucic,Robert C.; Storhoff,James J.; Elghanian,Robert; Taton,Thomas Andrew; Garimella,Viswanadham; Li,Zhi; Park,So Jung; Lu,Gang, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin,Chad A.; Letsinger,Robert L.; Park,So Jung, Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Park,So Jung; Taton,Thomas Andrew; Mirkin,Chad A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses thereof.
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Mirkin,Chad A.; Cao,Yun Wei; Jin,Rongchao, Non-alloying core shell nanoparticles.
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Mirkin,Chad A.; Cao,Yun Wei; Jin,Rongchao, Non-alloying core shell nanoparticles.
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Akhavan-Tafti, Hashem, Nonseparation assay methods.
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Akhavan-Tafti, Hashem, Nonseparation assay methods.
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Khanna Pyare (Mountain View CA) Ullman Edwin F. (Atherton CA), Novel alkyl substituted fluorescent compounds and polyamino acid conjugates.
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Law Say-Jong, Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof.
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Law Say-Jong (Westwood MA), Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof.
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Carr Stuart William,GB3 ; Pickup Karen Marie,GB3 ; Smith Philippa Margaret,GB3 ; Schilling Kurt Matthew,GB3, Oral care compositions.
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, Phenanthridinium ester as a labelling compound in luminometric immunoassay.
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Pease John S. ; Kirakossian Hrair ; Wagner Daniel B. ; Ullman Edwin F., Photoactivatable chemiluminescent matrices.
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Akiyoshi Yutaka (Tokyo JPX) Kobayashi Shinzo (Tokyo JPX) Kakimi Fujio (Shizuoka JPX) Matsukawa Hiroharu (Shizuoka JPX), Process for preparing microcapsule reagents for immunological response.
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Patel, Rajesh; Kurn, Nurith, Quantitative determination of nucleic acid amplification products.
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Rajesh Patel ; Nurith Kurn, Quantitative determination of nucleic acid amplification products.
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Clark Scott M., Reversible flow chromatographic binding assay.
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Clark Scott M., Reversible flow chromatographic binding assay.
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Clark Scott M., Reversible flow chromatographic binding assay system, kit, and method.
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Wagner Daniel B. (Raleigh NC) Baffi Robert A. (Devaulf PA), Sac having a marker linked thereto.
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Watkins, Michael; Prestigiacomo, Tony; Binder, Steven; Tan, Woei, Solid phase immobilization of phospholipids and cofactor proteins via covalent attachment.
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Geho W. Blair (533 Beechwood St. Wooster OH 44691) Lau John R. (1634 Morgan St. Wooster OH 44691), Therapy by vesicle delivery to the hydroxyapatite of bone.
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Martin Frank J. (San Francisco CA) Papahadjopoulos Demetrios P. (Lafayette CA) Hubbell Wayne L. (Orinda CA), Thiol reactive liposomes.
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Rabindran,Sridhar K.; Gibbons, Jr.,James J., Treatment of neoplasms with CCI-779/EKB-569 combination.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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[미국특허] Labeled liposome particle compositions and immunoassays therewith 원문보기

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[미국특허] Labeled liposome particle compositions and immunoassays therewith 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

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이 특허에 인용된 특허 (3) 인용/피인용 타임라인 분석

이 특허를 인용한 특허 (151) 인용/피인용 타임라인 분석

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