초록 ▼

Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, follo

Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, followed by a substantially constant continuous dosage in the range of 0.1 to 100 mcg/hr that maintains said level. The system is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-clonidine reservoir lamina that is the source of the clonidine for the continuous constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-clonidine contact adhesive layer that is the source of the clonidine for the priming dose and the means by which the system is attached to the skin.

대표청구항 ▼

A therapeutic system in the form of a skin patch for administering clonidine continuously and transdermally through a predetermined area of unbroken skin in a controlled manner for a prolonged time period to effect central alpha-adrenergic stimulation comprising: (a) a backing that is substantially

A therapeutic system in the form of a skin patch for administering clonidine continuously and transdermally through a predetermined area of unbroken skin in a controlled manner for a prolonged time period to effect central alpha-adrenergic stimulation comprising: (a) a backing that is substantially impermeable to clonidine, one face of which forms the top of the patch; (b) a clonidine reservoir adjacent the opposite face of the backing that contains an amount of clonidine sufficient to provide clonidine for said prolonged time period at a central alpha-adrenergic stimulating rate; (c) means for releasing clonidine from the reservoir at said rate to said predetermined area of skin; and (d) means for affixing the patch to said predetermined area of skin.