초록 ▼

The instant invention relates to liquid membrane capsule system (LMCS) which are made resistant to coalescence by means of an irreversible coating material present in the suspension phase. LMCS having this irreversible coating material are stable (i.e. resist coalescence) over relatively long period

The instant invention relates to liquid membrane capsule system (LMCS) which are made resistant to coalescence by means of an irreversible coating material present in the suspension phase. LMCS having this irreversible coating material are stable (i.e. resist coalescence) over relatively long periods of time with little or no applied agitation. These irreversibly coated LMCS can be pumped for long periods, are resistant to bile, pancreatin and solid matter and maintain their initial size distribution. The instant invention relates to methods of preparing the irreversibly coated LMCS. The LMCS of the instant invention exhibit resistance to rupture during pumping and passage over packing materials, such as glass beads or charcoal, thus making them of use in medical treatment processes such as renal dialysis and in the equipment used for such processes.

대표청구항 ▼

An improved liquid membrane capsule resistant to coalescence, said capsule comprising a globule of an emulsion suspended in an aqueous suspending phase wherein said emulsion comprises discrete microdroplets of an aqueous interior phase surrounded by a continuous, nonaqueous, oil, exterior phase, whe

An improved liquid membrane capsule resistant to coalescence, said capsule comprising a globule of an emulsion suspended in an aqueous suspending phase wherein said emulsion comprises discrete microdroplets of an aqueous interior phase surrounded by a continuous, nonaqueous, oil, exterior phase, wherein the improvement comprises an irreversible coating component comprising a long chain polymer possessing surface activity and the ability to gel or chain crosslink present in the aqueous suspending phase which forms an irreversible coating arround the oily, exterior phase of said capsule making same resistant to coalescence. An improved hemodialysis process of the type wherein a stream of blood from a patient is passed over one side of a dialysis mambrane through which membrane toxins diffuse from the blood which toxins are picked up by a dialysis fluid on the other side of the membrane, the purified blood being returned to the patient, the improvement comprising suspending in the dialysis fluid the stabilized liquid membrane capsule system (LMC) of claim 1, 2, 3 or 4 wherein the interior phase of the LMC is citric acid, which removes ammonia from the dialysis fluid, passing this dialysis fluid and the suspended LMC over activated carbon and phosphate ion exchange materials to remove other toxins and recirculating the dialysis fluid and suspended LMC to the dialysis membrane, the use of the LMC reducing the volume of dialysis fluid embployed by about 99%.