초록

Aqueous dispersions of spherules in the form of organized molecular layers of lipids, between which is encapsulated an aqueous phase containing at least one active substance are rendered more storage-stable by lyophilization. They can readily be reconstituted by re-hydration.

대표청구항 ▼

A process for preserving an aqueous dispersion of spherules in the form of organized molecular layers between which is encapsulated an aqueous phase containing at least one active substance, these layers consisting of at least one lipid having the formula X－Y wherein Y represents a lipophilic group

A process for preserving an aqueous dispersion of spherules in the form of organized molecular layers between which is encapsulated an aqueous phase containing at least one active substance, these layers consisting of at least one lipid having the formula X－Y wherein Y represents a lipophilic group and X represents an ionic or non-ionic group, the diameter of the spherules being from 100 to 50,000 A, which comprises lowering the temperature of the dispersion to below about -30°C. and evaporating it at a temperature from about 15°to about 60°C. under reduced pressure thereby producing a lyophilized product as a paste or a solid.