초록

A salt of a polymer, containing acid groups, soluble or dispersible in water or organic solvents, is combined with a salt-forming pharmaceutically effective compound for application, orally, topically, or systemically. A sustained release of the pharmaceutical compound is thus obtained.

대표청구항 ▼

A method of preparing a stable fluid composition for sustained release of a phramaceutical compound comprising the steps of: dissolving a pharmaceutically pure, acid group containing, water-insoluble, synthetic polymer and a salt-forming basic nitrogen containing pharmaceutically effective compound

A method of preparing a stable fluid composition for sustained release of a phramaceutical compound comprising the steps of: dissolving a pharmaceutically pure, acid group containing, water-insoluble, synthetic polymer and a salt-forming basic nitrogen containing pharmaceutically effective compound in organic solvent to form a salt of the polymer and the pharmaceutical compound in organic solution, slowly adding water to said salt solution without coagulating the polymer salt, and removing the organic solvent under vacuum to form a stable emulsion consisting of said salt in water; said polymer comprising from 10 to 75% by weight of at least one hydrophilic monomer and from 25 to 90% by weight of at least one hydrophobic monomer; at least 50% of the acid groups of said polymer being neutralized.