Gnczi Csaba (Budapest HUX) Korbonits Dezso (Budapest HUX) Kiss Pal (Budapest HUX) Palosi Endre (Budapest HUX) Heja Gergely (Budapest HUX) Szvoboda nee Kanzel Ida (Budapest HUX) Cser nee Kun Judit (Bu
출원인 / 주소
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T. (Budapest HUX 03)
인용정보
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1
초록▼
A process for the preparation of anthelmintic compounds of the formula: [Figure] wherein R1 is hydrogen or -COOR; R5 is C1 to C4 alkyl; R2 is halogen, alkyl, trifluoromethyl, alkoxy, aryloxy, or aralkoxy; and R4 is hydrogen, alkyl, cycloalkyl; alkenyl, alkynyl or aralkyl; or pharmaceutically accepta
A process for the preparation of anthelmintic compounds of the formula: [Figure] wherein R1 is hydrogen or -COOR; R5 is C1 to C4 alkyl; R2 is halogen, alkyl, trifluoromethyl, alkoxy, aryloxy, or aralkoxy; and R4 is hydrogen, alkyl, cycloalkyl; alkenyl, alkynyl or aralkyl; or pharmaceutically acceptable salts thereof comprises subjecting a bis compound of the formula: [Figure] to reduction to cleave the disulfide linkage and where R4 is other then hydrogen, subsequent reaction of the mercapto group. Intermediate compounds and a process for preparing same are also disclosed.
대표청구항▼
A compound of the formula [Figure] wherein R1 is hydrogen or -COOR5; R5 is C1 to C4 alkyl; R2 is hydrogen, halogen, C1 to C6 alkyl, trifluoromethyl or -OR3; and R3 is C1 to C4 alkyl, phenyl, naphthyl, phenyl-C1 to C4 alkyl or naphthyl-C1 to C4 alkyl, where the phenyl or naphthyl moiety is unsubstitu
A compound of the formula [Figure] wherein R1 is hydrogen or -COOR5; R5 is C1 to C4 alkyl; R2 is hydrogen, halogen, C1 to C6 alkyl, trifluoromethyl or -OR3; and R3 is C1 to C4 alkyl, phenyl, naphthyl, phenyl-C1 to C4 alkyl or naphthyl-C1 to C4 alkyl, where the phenyl or naphthyl moiety is unsubstituted or substituted by halogen, lower alkyl, lower alkoxy, lower alkylthio, carboxy, nitro, hydroxy, cyano, C1 to C4 alkylsulfinyl or C1 to C4 alkylsulfonyl; or a pharmaceutically acceptable salt thereof.
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이 특허에 인용된 특허 (1)
Beard Colin C. (Palo Alto CA) Edwards John A. (Los Altos CA) Fried John H. (Palo Alto CA), 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity.
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