초록 ▼

Chemically-modified quaternary-structured fiber collagens of minimum molecular length, diameter and periodicity, and containing a relatively high positive electrostatic charge are claimed as hemostatic agents. Specific examples are guanidinated, esterified, and guanidinated-esterified collagen fiber

Chemically-modified quaternary-structured fiber collagens of minimum molecular length, diameter and periodicity, and containing a relatively high positive electrostatic charge are claimed as hemostatic agents. Specific examples are guanidinated, esterified, and guanidinated-esterified collagen fibers of the type described.

대표청구항 ▼

An improved collagen hemostatic agent comprising native crosslinked fiber collagen of regularly staggered quaternary structure having a minimum molecular length of 7000 A°, a minimum molecular diameter of 20 A°, a minimum periodicity of 670-700 A°, and whose residual lysyl and carboxyl groups have b

An improved collagen hemostatic agent comprising native crosslinked fiber collagen of regularly staggered quaternary structure having a minimum molecular length of 7000 A°, a minimum molecular diameter of 20 A°, a minimum periodicity of 670-700 A°, and whose residual lysyl and carboxyl groups have been subjected respectively to at least one reaction selected from the group consisting of guanidination, esterification and guanidination-esterification to greatly enhance the net positive electrostatic charge of the fiber collagen.