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Vascular prosthesis suitable for use as a surgical graft is produced by implanting a rod or tube in a living host animal such as a sheep and allowing collagenous tissue to grow on the implant to form a coherent tubular wall of collagenous tissue. The implant is subsequently removed and the tubular w

Vascular prosthesis suitable for use as a surgical graft is produced by implanting a rod or tube in a living host animal such as a sheep and allowing collagenous tissue to grow on the implant to form a coherent tubular wall of collagenous tissue. The implant is subsequently removed and the tubular wall of collagenous tissue is stripped from the rod or tube and tanned in glutaraldehyde to serve as a vascular prosthesis.

대표청구항 ▼

A method of producing a vascular prosthesis suitable for use as a surgical graft in a human patient, comprising the steps of: implanting a rod or tube in the body of a living non-human, host animal at such a location as to cause growth of Type I collagenous tissue thereon; allowing said collagenous

A method of producing a vascular prosthesis suitable for use as a surgical graft in a human patient, comprising the steps of: implanting a rod or tube in the body of a living non-human, host animal at such a location as to cause growth of Type I collagenous tissue thereon; allowing said collagenous tissue to grow on the implanted rod or tube to form a coherent wall of said tissue; removing the rod or tube with said coherent wall of tissue from the body of the host animal; subjecting said coherent wall of collagenous tissue to glutaraldehyde tanning in order to produce cross-linking of collagen fibrils therein so as to increase the strength of the wall and also to impart immunological inertness and sterility thereto; and removing the rod or tube from within the coherent wall of collagenous tissue at any time subsequent to the removal of the rod or tube and coherent wall of collagenous tissue from the body of the host animal. A vascular prosthesis suitable for use as a surgical graft in a human patient, comprising: a coherent tubular wall of non-human Type I collageous tissue which has been subjected to glutaraldehyde tanning so as to comprise cross-linked collagen fibrils.