초록

Fluoxetine alone or a combination of fluoxetine and l-5-hydroxytryptophan, preferably also with a peripheral decarboxylase inhibitor, is administered to hypertensive mammals to lower blood pressure.

대표청구항 ▼

A method for lowering blood pressure in a hypertensive mammal in need of treatment which comprises the co-administration of hypotensively effective amounts of fluoxetine and l-5-hydroxytryptophane or pharmaceutically acceptable salts thereof, the amount of said combination administered being signifi

A method for lowering blood pressure in a hypertensive mammal in need of treatment which comprises the co-administration of hypotensively effective amounts of fluoxetine and l-5-hydroxytryptophane or pharmaceutically acceptable salts thereof, the amount of said combination administered being significantly effective to reduce the blood pressure of said hypertensive mammal, compared to each alone. A method for lowering blood pressure in hypertensive mammals in need of treatment which comprises the co-administration of hypotensively-effective amounts of fluoxetine, and l-5-tryptophan or pharmaceutically acceptable salts thereof, the amount of said combination, compared to each alone, being significantly effective to reduce the blood pressure of said hypertensive mammals plus a peripheral decarboxylase inhibitor in an amount sufficient to prevent side effects attributable to serotonin. A method for lowering blood pressure in hypertensive mammals in need of treatment which comprises the administration to such a mammal of an antihypertensive amount of fluoxetine or a pharmaceutically-acceptable salt thereof.