초록 ▼

Pharmaceutical coatings in the form of aqueous dispersion of a water insoluble polymer prepared by dissolving the polymer in a water immiscible organic solvent, emulsifying the organic solution in water, optionally with the aid of additives, and stripping the organic solvent from the system to provi

Pharmaceutical coatings in the form of aqueous dispersion of a water insoluble polymer prepared by dissolving the polymer in a water immiscible organic solvent, emulsifying the organic solution in water, optionally with the aid of additives, and stripping the organic solvent from the system to provide a colloidal, or near colloidal, aqueous dispersion or latex of small, even sized polymeric particles which are applied to pharmaceutical dosages from highly loaded latices. The latexes, which display resistance to bacterial and mold growth and, when combined with selected additives, provides convenient, attractive coating compositions which afford excellent protection and varied release properties to pharmaceutical dosages.

대표청구항 ▼

A coating composition for pharmaceutical dosages comprising: a bacteria growth resistant aqueous dispersion of submicron average sized spherical particles formed of at least one water insoluble polymer selected the group consisting of ethyl cellulose, polyvinyl acetate phthalate, cellulose acetate p

A coating composition for pharmaceutical dosages comprising: a bacteria growth resistant aqueous dispersion of submicron average sized spherical particles formed of at least one water insoluble polymer selected the group consisting of ethyl cellulose, polyvinyl acetate phthalate, cellulose acetate phthalate, and hydroxy propyl methyl cellulose phthalate; at least one annealing agent in the form of a water soluble polymer; at least one plasticizer selected from the group consisting of propylene glycol, glycerin, glyceryl triacetate and polyethylene glycol; an emulsifying agent; and an emulsion stabilizer selected from the group consisting of cetyl alcohol and n-decane; the solids contents of the aqueous dispersion being at least 40 percent by weight. A coating composition as set forth in claim 1 in which the water soluble polymer constituting the annealing agent is selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methylcellulose, methyl cellulose, methyl ethyl cellulose, polyvinylpyrrolidone and sodium carboxymethylcellulose.