초록 ▼

Tissue cells such as islet of Langerhans cells or liver cells are encapsulated within a spheroidal semipermeable membrane comprising a polysaccharide having acidic groups cross-linked with a polymer having a molecular weight greater than 3,000. The cells within the microcapsules are viable, healthy,

Tissue cells such as islet of Langerhans cells or liver cells are encapsulated within a spheroidal semipermeable membrane comprising a polysaccharide having acidic groups cross-linked with a polymer having a molecular weight greater than 3,000. The cells within the microcapsules are viable, healthy, physiologically active and capable of ongoing metabolism. The encapsulated cells are useful for implantation in a mammalian body to produce substances and effect chemical changes characteristic of the cells in vivo tissue.

대표청구항 ▼

An artificial organ suitable for implantation in a mammalian body comprising a microcapsule comprising a polysaccharide having acidic groups thereof cross-linked with a polymer having a molecular weight greater than 3,000, said membrane being no greater than about 2.0 mm in diameter and containing o

An artificial organ suitable for implantation in a mammalian body comprising a microcapsule comprising a polysaccharide having acidic groups thereof cross-linked with a polymer having a molecular weight greater than 3,000, said membrane being no greater than about 2.0 mm in diameter and containing one or more viable, healthy, physiologically active living tissue cells, said microcapsule being impermeable to immune system proteins but permeable to tissue nutrients and metabolic products produced by the tissue.