초록 ▼

An osmotic drug (or other beneficial substance) delivery system comprises a multi-chamber compartment formed by an external shell and one or more chamber-dividing walls each with a small orifice, of a microporous material and overlayers of semipermeable membranes completely covering the outer shell

An osmotic drug (or other beneficial substance) delivery system comprises a multi-chamber compartment formed by an external shell and one or more chamber-dividing walls each with a small orifice, of a microporous material and overlayers of semipermeable membranes completely covering the outer shell of all but one chamber and substantially covering the outer shell of the remaining chamber. Osmotic agents, adjuvants, enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chambers covered by the semipermeable membrane, and external fluids that diffuse into those chambers form solutions and by osmotic pressure are forced through the orifice to the drug chamber to form a solution thereof and then through the exposed microporous shell to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell.

대표청구항 ▼

An osmotic delivery system shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other beneficial substance comprising a compartment consisting of 2 or more chambers in series, the chambers being adapted to house osmotically active agents,

An osmotic delivery system shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other beneficial substance comprising a compartment consisting of 2 or more chambers in series, the chambers being adapted to house osmotically active agents, adsorption adjuvants, drugs, and pro-drugs, the chambers being formed by an external shell and 1 or more chamber-dividing walls, each chamber-dividing wall having a micro-orifice connecting adjacent chambers, the external shell and chamber-dividing walls being of a rigid microporous material; one or more succesive overlayers of a semipermeable membrane, the first overlayer completely covering the external shell of all but one chamber and substantially covering the external shell of the one chamber leaving exposed a microporous drug-emitting surface; and each successive overlayer completely covering all but one more chamber and substantially covering the one more chamber; and optionally including a quick release loading dose of drug external to and covering the microporous drug-emitting surface.