초록 ▼

An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a wall surrounding a lumen divided into a first compartment containing a drug that is separated by a hydrogel partition from a second compartment containing a different drug. An orifice

An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a wall surrounding a lumen divided into a first compartment containing a drug that is separated by a hydrogel partition from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug formulation from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug formulation from the second compartment. In operation, drug formulation is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug formulation in each compartment thereby producing in each compartment a solution containing drugs, and by the expansion and swelling of the hydrogel, whereby drug formulation is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.

대표청구항 ▼

An osmotic therapeutic device for the controlled delivery of beneficial drugs to a biological environment, the device consisting essentially of: (a) a wall formed of a semipermeable material permeable to the passage of an external fluid present in the environment and substantially impermeable to the

An osmotic therapeutic device for the controlled delivery of beneficial drugs to a biological environment, the device consisting essentially of: (a) a wall formed of a semipermeable material permeable to the passage of an external fluid present in the environment and substantially impermeable to the passage of drug, the semipermeable wall surrounding and forming; (b) a first compartment containing a drug formulation that exhibits an osmotic pressure gradient across the semipermeable wall against an external fluid; (c) a second compartment containing a drug formulation that exhibits an osmotic pressure gradient across the semipermeable wall against an external fluid; (d) a partition positioned between the first and second compartments, which partition is formed of a hydrogel that expands in the presence of fluid; (e) a first orifice in the wall communicating with the first compartment and the exterior of the device for delivering drug formulation from the first compartment to the environment over a prolonged period of time; and, (f) a second orifice in the wall communicating with the second compartment and the exterior of the device for delivering drug formulation from the second compartment to the environment over a prolonged period of time.